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Control of bacterial transcription, translation and replication by (p)ppGpp
Current Opinion in Microbiology, 2008The small nucleotides pppGpp and ppGpp (or (p)ppGpp) are rapidly synthesized in response to nutritional stress. In Escherichia coli, the enzymes RelA and SpoT are triggered by different starvation signals to produce (p)ppGpp. In many Gram-positive bacteria this is carried out by RelA and two small homologs. (p)ppGpp, along with the transcription factor
Anjana, Srivatsan, Jue D, Wang
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(p)ppGpp: the magic governor of bacterial growth economy
Current Genetics, 2019A fundamental question in microbiology is how bacterial cells manage to coordinate gene expression with cell growth during adapting to various environmental conditions. Although the cellular responses to changing environments have been extensively studied using transcriptomic and proteomic approaches, it remains poorly understood regarding the ...
Manlu Zhu, Yige Pan, Xiongfeng Dai
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Microbiology and Molecular Biology Reviews
SUMMARY Bacteria are constantly exposed to changing environmental conditions, and to survive they need to adapt quickly, adjusting their gene expression and metabolism to make the most of the resources available. One of the mechanisms involved is the stringent response, characterized by production of specific guanosine derivatives ...
Katarzyna Potrykus +3 more
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SUMMARY Bacteria are constantly exposed to changing environmental conditions, and to survive they need to adapt quickly, adjusting their gene expression and metabolism to make the most of the resources available. One of the mechanisms involved is the stringent response, characterized by production of specific guanosine derivatives ...
Katarzyna Potrykus +3 more
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Selective Fluorescent Chemosensor for the Bacterial Alarmone (p)ppGpp
Journal of the American Chemical Society, 2008We have developed the first selective fluorescent chemosensor (PyDPA) for (p)ppGpp, a bacterial and plant alarmone. By using pyrene-excimer fluorescence, PyDPA shows very good selectivity for (p)ppGpp from among other nucleotides in water. PyDPA was used for the real-time detection of in vitro ppGpp synthesis by bacterial ribosomal complexes.
Rhee, Hyun-Woo +7 more
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New horizons for (p)ppGpp in bacterial and plant physiology
Trends in Microbiology, 2006A hyperphosphorylated guanosine nucleotide, (p)ppGpp, was initially identified as the effector molecule responsible for the stringent response in Escherichia coli. However, a rapidly growing number of reports proves that (p)ppGpp-mediated regulation is conserved in many bacteria and even in plants.
Kristien, Braeken +4 more
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Regulation of nitrogen starvation responses by the alarmone (p)ppGpp in rice
Journal of Genetics and Genomics, 2022Nitrogen is an essential macronutrient for all living organisms and is critical for crop productivity and quality. In higher plants, inorganic nitrogen is absorbed through roots and then assimilated into amino acids by the highly conserved glutamine synthetase/glutamine:2-oxoglutarate aminotransferase (GS/GOGAT) cycle.
Hanwen Li +18 more
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Mutations that overcome plasmid-mediated relaxation affect (p)ppGpp
Molecular and General Genetics MGG, 1980A recombinant plasmid, pMY3, was constructed in this laboratory to express the amber suppressor allele, Su+7, of the tRNATrp gene from E. coli (Yarus, 1979a). This plasmid also relaxes control of the synthesis of all stable RNA species in its host cell after amino acid deprivation.
L, Breeden, M, Yarus
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Isolation of RNA Polymerase Suppressors of a (p)ppGpp Deficiency
2003Publisher Summary This chapter discusses the isolation of RNA polymerase suppressor of a (p) ppGpp deficiency. A complete deficiency of ppGpp (ppGpp0) is found when both the relA and spoT genes are deleted from an Escherichia coli (E.Coli) K12 strain, MG1655.
Helen, Murphy, Michael, Cashel
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(p)ppGpp and the Stringent Response: An Emerging Threat to Antibiotic Therapy
ACS Infectious Diseases, 2019In 1969, Cashel and Gallant first observed the presence of (p)ppGpp-the signaling molecule of the stringent response-in starved bacterial cells. Fifty years later, (p)ppGpp and the stringent response have emerged as essential master regulators of not only the bacterial response to stress but also almost all aspects of bacterial physiology, virulence ...
Joanne Hobbs, Alisdair Boraston
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Dependence of RelA-Mediated (p)ppGpp Formation on tRNA Identity
Biochemistry, 2011The bacterial stringent response is a cellular response to amino acid limitations and is characterized by the accumulation of the alarmone polyphosphate guanosine ((p)ppGpp). A key molecular event leading to (p)ppGpp synthesis is the binding of a deacylated tRNA to the vacant A-Site of a ribosome.
Roshani, Payoe, Richard P, Fahlman
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