Results 131 to 140 of about 18,483,123 (229)

Staphylococcus aureus COL: An Atypical Model Strain of MRSA That Exhibits Slow Growth and Antibiotic Tolerance due to a Mutation in PRPP Synthetase

Molecular Microbiology, Volume 124, Issue 3, Page 189-203, September 2025.
COL is an unusual “model” strain of Staphylococcus aureus that exhibits slow growth and multidrug antibiotic tolerance. This phenotype is primarily due to a mutation in Prs, which synthesizes the core metabolite phosphoribosyl pyrophosphate (PRPP). Introduction of the COL Prs allele into the antibiotic‐susceptible strain Newman confers tolerance, while
Claire E. Stevens, Ashley T. Deventer, Paul R. Johnston, Phillip T. Lowe, Alisdair B. Boraston, Joanne K. Hobbs   +5 more
wiley   +1 more source

The actinobacterial transcription factor RbpA binds to the principal sigma subunit of RNA polymerase [PDF]

, 2013
RbpA is a small non-DNA-binding transcription factor that associates with RNA polymerase holoenzyme and stimulates transcription in actinobacteria, including Streptomyces coelicolor and Mycobacterium tuberculosis.
Aline Tabib-Salazar, Alting-Mees, Babcock, Bergendahl, Bierman, Bing Liu, Bougdour, Bucca, Burgess, Buttner, Campbell, Campbell, Chakraburtty, Cornilescu, Dey, England, Feklistov, Fletcher, Fontán, Forti, Gaal, Gabriel, Gruber, Haugen, Herring, Hsu, Hu, Hu, Huang, Karimova, Karimova, Kathleen O’Dwyer, Kelemen, Kelley, Kieser, Kim, Krishna, Manganelli, Manganelli, Mantsyzov, Marchant, Marie-Laure Parsy, Mark S. Paget, McClellan, Monteil, Monteil, Murakami, Newell, Otani, O’Connor, Paget, Paget, Paget, Paget, Panina, Peter J. Simpson, Philip Doughty, Pratt, Raffaelle, Richard A. Lewis, Rieping, Saecker, Sattler, Schwartz, Selmer, Sivashanmugam, Somadri Ghosh, Steve J. Matthews, Studier, Studier, Typas, van Wezel, Vassylyev, Ventura, Viollier, Vockenhuber, Wang, WHO, Young, Zhang, Zhang, Zhuo, Österberg   +82 more
core   +1 more source

Robotic‐Assisted Capture‐Systematic Evolution of Ligands by Exponential Enrichment of RNA Aptamers Binding to Small Molecules

ChemBioChem, Volume 26, Issue 15, August 22, 2025.
This study demonstrates the rapid selection of RNA aptamers that can target various small molecules through a newly established automated capture‐systematic evolution of ligands by exponential enrichment technique. Throughout the study, this method is applied to aptamer selection for several small molecules, resulting in aptamers that bind with high ...
Tjasa Legen, Günter Mayer
wiley   +1 more source

Characterization of water and wildlife strains as a subgroup of Campylobacter jejuni using DNA microarrays.

, 2013
Campylobacter jejuni is the leading cause of human bacterial gastroenteritis worldwide, but source attribution of the organism is difficult. Previously, DNA microarrays were used to investigate isolate source, which suggested a non-livestock source of ...
Altschul, Brandl, Champion, Dingle, Dingle, Dorrell, Ethelberg, Francisco, French, Gundogdu, Harris, Hepworth, Hepworth, Hinchliffe, Howard, Huelsenbeck, Jensen, Jorgensen, Joshua, Kalendar, Karenlampi, Katoh, Katoh, Kemp, Kim, Kim, King, Kwan, Kwan, Manning, McCarthy, Mellmann, Miller, Moen, Murphy, Ogden, On, Park, Pearson, Petersen, Ronquist, Rosef, Rosef, Sails, Sanad, Schonberg-Norio, Skirrow, Skirrow, Stabler, Staden, Staden, Taboada, Taboada, Tam, Tam, Wilson   +55 more
core   +1 more source

Polyphosphate and associated enzymes as global regulators of stress response and virulence in Campylobacter jejuni [PDF]

, 2016
Campylobacter jejuni (C. jejuni), a Gram-negative microaerophilic bacterium, is a predominant cause of bacterial foodborne gastroenteritis in humans worldwide.
Gangaiah, Dharanesh, Kumar, Anand, Rajashekara, Gireesh, Torrelles, Jordi B.   +3 more
core   +1 more source

Macrophage‐derived reactive oxygen species promote Salmonella aggresome formation contributing to bacterial antibiotic persistence

iMeta, Volume 4, Issue 4, August 2025.
In this study, we reveal that macrophage‐derived reactive oxygen species (ROS) can trigger the rapid formation of Salmonella aggresomes, which substantially contribute to the increased frequency of persisters induced by phagocytosis. Salmonella containing aggresomes exhibited a dormant phenotype characterized by reduced adenosine triphosphate (ATP ...
Xiao Chen, Kefan Fang, Bo Li, Yingxing Li, Yuehua Ke, Weixin Ke, Tian Tian, Yifan Zhao, Linqi Wang, Jing Geng, Mark C. Leake, Fan Bai   +11 more
wiley   +1 more source

(p)ppGpp and DksA play crucial role in reducing the efficacy of β-lactam antibiotics by modulating bacterial membrane permeability

bioRxiv
The key signaling molecules in the bacterial stress sensing pathway, the alarmone (p)ppGpp and transcription factor DksA, help in survival during nutritional deprivation and exposure to xenobiotics by modulating cellular metabolic pathways.
Meenal Chawla, Jyoti Verma, Shashi Kumari, Tushar Matta, Tarosi Senapati, Prabhakar Babele, Yashwant Kumar, R. Bhadra, Bhabatosh Das   +8 more
semanticscholar   +1 more source

Putative Transcriptional Regulator LysR1 Is Required for Full Virulence of Erwinia amylovora

Plant Pathology, Volume 74, Issue 6, Page 1697-1706, August 2025.
Erwinia amylovora lysR1 transcription factor mutants have a sharply reduced ability to cause fire blight disease, not due to lysine auxotrophy but a deficiency in production of the virulence factor exopolysaccharide amylovoran. ABSTRACT Fire blight, caused by the gram‐negative bacterium Erwinia amylovora, is a serious disease of apple and pear trees ...
Sara M. Klee, Judith P. Sinn, Jeremy B. Held, Francesco Pacini, Aleah C. Holmes, Melissa Finley, Brian L. Lehman, Kari A. Peter, Timothy W. McNellis   +8 more
wiley   +1 more source

Cell cycle control and environmental response by second messengers in Caulobacter crescentus

BMC Bioinformatics, 2020
Background Second messengers, c-di-GMP and (p)ppGpp, are vital regulatory molecules in bacteria, influencing cellular processes such as biofilm formation, transcription, virulence, quorum sensing, and proliferation.
Chunrui Xu, Bronson R. Weston, John J. Tyson, Yang Cao   +3 more
doaj   +1 more source

Conceptual model of E. coli transcriptional machinery [PDF]

, 2011
At the moment one type of analysis of transcription regulatory networks (TRNs) in prokaryotes is topological analysis of graph structure of possible regulatory interaction links (see for example [1]).
Anatoly Sorokin, Svetlana G. Kamzolova, Timur Dzhelyadin   +2 more
core   +2 more sources