Results 141 to 150 of about 18,483,123 (229)

Comparative study of adenosine 3′‐pyrophosphokinase domains of MuF polymorphic toxins

FEBS Open Bio, Volume 15, Issue 7, Page 1103-1112, July 2025.
With the ultimate goal of understanding the association of toxin‐immunity modules to temperate phages, we characterized toxins from three prophages and examined cross‐protection from immunity proteins. The toxins exhibit adenosine 3′‐pyrophosphokinase activity and are toxic in Escherichia coli.
Eloïse M. Paulet, Julia Bartoli, Atakan Kabtan, Chloé M. Piras, Audrey C. Tempier, Eric Cascales, Julie P. Viala   +6 more
wiley   +1 more source

The PAMP c-di-AMP Is Essential for Listeria monocytogenes Growth in Rich but Not Minimal Media due to a Toxic Increase in (p)ppGpp [PDF]

, 2015
Aaron T. Whiteley, Alex J. Pollock, Daniel A. Portnoy   +2 more
openalex   +3 more sources

Direct detection of stringent alarmones (pp)pGpp using malachite green

Microbial Cell
The alarmone (p)ppGpp serves as the signalling molecule for the bacterial universal stringent response and plays a crucial role in bacterial virulence, persistence, and stress adaptation. Consequently, there is a significant focus on developing new drugs
Muriel Schicketanz, Magdalena Petrová, Dominik Rejman, Margherita Sosio, Stefano Donadio, Yong Everett Zhang   +5 more
doaj   +1 more source

The C-Terminal RRM/ACT Domain Is Crucial for Fine-Tuning the Activation of ‘Long’ RelA-SpoT Homolog Enzymes by Ribosomal Complexes

Frontiers in Microbiology, 2020
The (p)ppGpp-mediated stringent response is a bacterial stress response implicated in virulence and antibiotic tolerance. Both synthesis and degradation of the (p)ppGpp alarmone nucleotide are mediated by RelA-SpoT Homolog (RSH) enzymes which can be ...
Hiraku Takada, Hiraku Takada, Mohammad Roghanian, Mohammad Roghanian, Victoriia Murina, Victoriia Murina, Ievgen Dzhygyr, Ievgen Dzhygyr, Rikinori Murayama, Genki Akanuma, Gemma C. Atkinson, Abel Garcia-Pino, Abel Garcia-Pino, Vasili Hauryliuk, Vasili Hauryliuk, Vasili Hauryliuk   +15 more
doaj   +1 more source

Pb2+ tolerance by Frankia sp. strain EAN1pec involves surface-binding [PDF]

, 2017
Several Frankia strains have been shown to be lead-resistant. The mechanism of lead resistance was investigated for Frankia sp. strain EAN1pec. Analysis of the cultures by scanning electron microscopy (SEM), energy dispersive X-ray spectroscopy (EDAX ...
Furnholm, Teal, Rehan, Medhat, Tisa, Louis S., Wishart, Jessica   +3 more
core   +2 more sources

Nucleotides: Structure and Properties [PDF]

, 2005
Nucleotides consist of a nitrogen-containing base, a five-carbon sugar, and one or more phosphate groups. Cells contain many types of nucleotides, which play a central role in a wide variety of cellular processes, including metabolic regulation and the ...
Bowater, RP
core   +1 more source

The Emerging Role of (p)ppGpp in DNA Repair and Associated Bacterial Survival against Fluoroquinolones

Gene Expression
(p)ppGpp binds to RNA polymerase, causing stalling at damaged DNA sites and subsequent backtracking, which facilitates the recognition and removal of damaged DNA by repair proteins.
Smitha Sivapragasam
semanticscholar   +1 more source

Comprehensive analysis of type 1 fimbriae regulation in fimB -null strains from the multidrug resistant Escherichia coli ST131 clone [PDF]

, 2016
Summary\ud \ud Uropathogenic Escherichia coli (UPEC) of sequence type 131 (ST131) are a pandemic multidrug resistant clone associated with urinary tract and bloodstream infections.
Beatson, SA, Lo, AW, Paterson, DL, Peters, KM, Phan, M-D, Roberts, LW, Sarkar, S, Schembri, MA, Tan, L, Totsika, M, Ulett, GC, Upton, M   +11 more
core   +3 more sources

Mycobacterium tuberculosis transcription machinery: Ready to respond to host attacks [PDF]

, 2016
Regulating responses to stress is critical for all bacteria, whether they are environmental, commensal, or pathogenic species. For pathogenic bacteria, successful colonization and survival in the host are dependent on adaptation to diverse conditions ...
Flentie, Kelly, Garner, Ashley L, Stallings, Christina L   +2 more
core   +2 more sources

Ribosomal selection of mRNAs with degenerate initiation triplets [PDF]

, 2017
To assess the influence of degenerate initiation triplets on mRNA recruitment by ribosomes, five mRNAs identical but for their start codon (AUG, GUG, UUG, AUU and AUA) were offered to a limiting amount of ribosomes, alone or in competition with an ...
Brandi, Letizia, Giuliodori, Anna M, Gualerzi, Claudio O, He, Chengguang, Pon, Cynthia L, Sabatini, Paola   +5 more
core   +1 more source