Results 161 to 170 of about 34,114,677 (275)

Author Correction: A new approach for approximating the p-value of a class of bivariate sign tests. [PDF]

Sci Rep, 2023
Shanan IAA, Abd-Elfattah EF, Abd El-Raheem AEM.   +2 more
europepmc   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

The conception of value: an analysis about the objectivity of values proposed by P. Grice

, 2012
-This article aims at analyzing specific topics of the first chapter "Value and objectivity" of P Grice's book Conception of value. Through this analysis we intend to do a metaethical discussion about the possibility of an objectivity ...
De Lacerda Nunes, Lauren, Garmendia Da Trindade, Gabriel   +1 more
core   +1 more source

Overfitting and subgroup P -value inconsistencies in mortality prediction analysis of a VV-ECMO cohort. [PDF]

Lung India
Guniganti SK, Goud BVK.
europepmc   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

SignifiKANTE: efficient P-value computation for gene regulatory networks. [PDF]

Bioinformatics
Woller F, Martini P, Sen S, Blumenthal DB, Hartebrodt A.   +4 more
europepmc   +1 more source

Misinterpretations of Significance Testing Results Near the P-Value Threshold in the Urologic Literature. [PDF]

Cureus, 2023
Manda PR, Kuchakulla M, Hochu G, Mudiam P, Watane A, Syed A, Ghomeshi A, Ramasamy R.   +7 more
europepmc   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Compartmentalized Liquid Microenvironments of Pickering Emulsion Droplets for Continuous-Flow Catalysis

JACS Au
Peng Yang, Yahong Yao, Rammile Ettelaie, Yumeng Mi, Nan Xue, Anpeng Hu, Ming Zhang, Hengquan Yang   +7 more
doaj   +1 more source

Kernel-smoothed permutation for extreme P-value estimation in genetic association studies. [PDF]

Genetics
Bian J, Wu J, Ethan MacDonald M, Wu L, Long Q, Li C.   +5 more
europepmc   +1 more source