Results 181 to 190 of about 1,418,757 (266)

Modelling longitudinal and time-to-event data: a phase IV simulation study comparing R package implementations of joint models with time-varying Cox proportional-hazards regression, and the two-stage approach. [PDF]

BMC Med Res Methodol
Heege J, Greven S, Schaeffner E, Grittner U, Aigner A.   +4 more
europepmc   +1 more source

Sudden anaerobization in Amphibacillus xylanus increases intracellular labile ferrous iron and inhibits cell growth

FEBS Open Bio, EarlyView.
Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata, Yoichi Sakai, Keisuke Tanaka, Etsuro Yoshimura, Ken Kitano, Morio Ishikawa, Tadahiro Nakamoto, Tsutomu Takayama, Hirofumi Inoue, Kaho Nomura, Tomonori Suzuki, Masataka Uchino, Akira Abe, Youichi Niimura   +13 more
wiley   +1 more source

Splitpea: a Python package for protein-protein interaction network rewiring analysis due to alternative splicing. [PDF]

Bioinformatics
Zhong J, Cantu A, Dannenfelser R, Yao V.
europepmc   +1 more source

One size does not fit all: An in vitro evaluation of the effects of bezafibrate and medroxyprogesterone acetate on human SH‐SY5Y and U‐87 MG cancer cells

FEBS Open Bio, EarlyView.
Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar, Francesco Michelangeli, Farhat Latif Khanim, Christopher Martin Bunce, William Eustace Basil Johnson   +4 more
wiley   +1 more source

Developing general practitioner and consumer supports for genomics in Australian primary care: a mixed-methods protocol. [PDF]

BMJ Open
Long JC, Archibald AD, Lamprell K, Dawson-McClaren B, Kraan C, Springer A, Dive L, Newson AJ, Watts G, Holmes I, Cutler H, Jeet V, Trainer A, Best S, Delatycki M, Kirk EP, Laing N, Ferrie M, Freeman L, Willcock S, Spanos S, Gilkes L, Cini J, Edwards S, Leibowitz R, Mahadeva J, Foo D, Churruca K, Patel R, Braithwaite J.   +29 more
europepmc   +1 more source

Lipopolysaccharide uptake is augmented in lipopolysaccharide‐tolerant mouse macrophage‐like cells via increased CD14 expression

FEBS Open Bio, EarlyView.
In normal (nontolerant) cells, CD14 is crucial for both LPS uptake and LPS signaling. In LPS‐tolerant cells, in which LPS‐induced TNF‐α and IFN‐β production is suppressed, there is a dramatic increase in surface CD14 expression. The overexpressed CD14 in LPS‐tolerant cells is responsible for the enhanced LPS uptake without inducing pro‐inflammatory ...
Saeka Nishihara, Takayuki Manabe, Mika Jouta, Kiyoshi Kawasaki   +3 more
wiley   +1 more source

Patient Empowerment in the Context of Outpatient Surgery Using the Example of Orthopedics (Power-AOP): Protocol for a Mixed Methods Study. [PDF]

JMIR Res Protoc
Giebel GD, Giebel GM, Milinkovic D, Abels C, Cissarek HR, Perka C, Zander S, Schneider U, Kern M, Kladny B, Okan O, Bitzer EM, Wasem J, Hüer T, Valbert F.   +14 more
europepmc   +1 more source

Time‐restricted feeding prior to Mycobacterium tuberculosis infection reduces tissue CD4+ T cells with limited impact on bacterial clearance

FEBS Open Bio, EarlyView.
Time‐restricted feeding (TRF) in mice increased liver fatty acid oxidation and decreased fatty acid biosynthesis. These alterations persisted when TRF was discontinued and the host was infected with Mycobacterium tuberculosis. Pre‐exposure to TRF did not alter tissue (lung and spleen) mycobacterial burden but significantly reduced CD3+ T cells in lungs
Ashish Gupta, Nidhi Yadav, Subhasmita Das, R. Rajendra Kumar Reddy, Nupur Sharma, Amol Ratnakar Suryawanshi, Jaswinder Singh Maras, Ranjan Kumar Nanda   +7 more
wiley   +1 more source

West Nile Virus Transmission Suitability Modeling for <i>Culex pipiens</i> via Temperature and Humidity. [PDF]

Geohealth
Jones HM, Brett-Major DM, Fauver JR, Gwon Y, Bell JE.   +4 more
europepmc   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source