Results 201 to 210 of about 2,076,709 (312)

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

FEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez, Diana Ascencio, Miguel Vallebueno‐Estrada, Eduardo González‐Orozco, Christian Eduardo Martínez‐Guerrero, Rafael Montiel, Alexander DeLuna   +6 more
wiley   +1 more source

Correction to "Development, Suitability and Comprehensibility of a QR Code-Enabled Educational Package to Improve Self-Care Practices Among Patients With Type 2 Diabetes: A Multimethod Study in Iran". [PDF]

Health Expect
europepmc   +1 more source

Recent Advances in Performance-Driven Multiscale Strategies for Epoxy-Based Underfill Materials for Advanced Packaging. [PDF]

Polymers (Basel)
Wang Y, Wang Y, Wu Y, Yan Y, Li Y, Sun D, Xie A.   +6 more
europepmc   +1 more source

Identifying and characterising a plant GH1 β‐glucosidase that exhibits hydrolytic activity on N‐linked glucopyranoside

FEBS Open Bio, EarlyView.
We report the first β‐glucosidase with demonstrated hydrolytic activity on an N‐linked glycopyranoside. The enzyme, native to maize, was biochemically characterised for this novel reaction, and structural modelling of the enzyme–substrate complex revealed several clues to the underlying reduced catalytic rate relative to its native O‐glycopyranoside ...
Hani Gharabli, Carlotta Chiesa, Maher Abou Hachem, Ditte Hededam Welner   +3 more
wiley   +1 more source

Development and National Implementation of a Standardized Physiotherapy Assessment Package for Pediatric Asthma and Dysfunctional Breathing. [PDF]

Pediatr Pulmonol
Wells C, Hepworth C, Barker N.
europepmc   +1 more source

Structural studies and functional engineering of NanX: an anhydro‐sialic acid transporter from Escherichia coli

FEBS Open Bio, EarlyView.
Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty, Kelsi R. Hall, Zachary D. Tillett, Liam S. Turk, James S. Davies, Michael J. Currie, Hamish G. Brown, Sepideh Valimehr, Peter D. Mace, Andrew E. Whitten, Santosh Panjikar, Eric Hanssen, Rachel A. North, Renwick C.J. Dobson   +13 more
wiley   +1 more source

Important potential risks not reflected in Japanese drug labeling: implications for risk management plan termination. [PDF]

Daru
Kameyama N, Ide A, Maeda H.
europepmc   +1 more source

In silico and in vitro exploration of a tyrosinase for biocatalytic production of catechols

FEBS Open Bio, EarlyView.
Tyrosinase from Ralstonia pseudosolanacearum is a promising biocatalyst for producing valuable catechols from monophenol substrates. This tyrosinase is uniquely suited to this due to its high monophenolase : diphenolase ratio. We combined in silico docking and in vivo kinetic characterisation of this tyrosinase with 11 industrially relevant monophenols,
James Britton, Fang Zhao, Reeta Davis, Meg Walsh, Kevin E O'Connor, David O'Connell, Tanja Narancic   +6 more
wiley   +1 more source

Multicentre phase III randomised controlled trial to evaluate effectiveness of the Both EARS (BEARS) virtual reality training package to maximise hearing abilities in children and young people with bilateral cochlear implants: the BEARS protocol. [PDF]

BMJ Open
Vickers D, Buelt L, Arram L, Picinali L, Salorio Corbetto M, Chowdhury K, Clarke CS, Freemantle N, Jiang D, Parmar B, Early F, Driver S, Bordea E, Hill T, Cullington H, Kukiewicz F, Rocca C, Kitterick P, Corbett F, Nightingale R, Blackstone J, Ahmed N, Somerset S, Zalk N, Mahon M.   +24 more
europepmc   +1 more source