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Individualized pharmacotherapy with paclitaxel
Current Opinion in Oncology, 2007More than two decades of clinical experience with paclitaxel as an anticancer drug have contributed significantly to the optimization of today's application schemes and patients' safety. Recent knowledge about interindividual pharmacokinetic variability and population modeling provides a novel scientific basis for an improved and individualized ...
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Gemcitabine combined with paclitaxel or paclitaxel/trastuzumab in metastatic breast cancer
Seminars in Oncology, 2003The combination of gemcitabine and paclitaxel in metastatic breast cancer is attractive because of the good single-agent activity of each, the different mechanisms of antitumor effect, and the, generally, nonoverlapping toxicity profiles of the agents.
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Overview of Paclitaxel (TAXOL®)
Seminars in Oncology Nursing, 1993The history of development of paclitaxel (TAXOL [Bristol-Myers Squibb Co., Princeton, NJ]) is a long story and serves as a model of perseverance for those involved in drug development. Notations of the use of products of the yew tree date back to the Celts, but it was in the 1950s to the 1960s that the National Cancer Institute (NCI) selected the ...
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Pharmacogenetics of paclitaxel metabolism
Critical Reviews in Oncology/Hematology, 2007Paclitaxel is one of the most widely used and effective anticancer drugs. Paclitaxel's clinical utility spans many tumor sites, including treatment of ovarian, breast, lung, head and neck, and unknown primary cancers. As is the case with most chemotherapy drugs, paclitaxel is administered empirically with little individualization of dose other than ...
Jennifer L. Spratlin, Michael B. Sawyer
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A facile N-debenzoylation of paclitaxel: Conversion of paclitaxel to docetaxel
Tetrahedron Letters, 1999AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Prakash Jagtap, David G. I. Kingston
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Pharmacology and Pharmacokinetics of Paclitaxel
Annals of Pharmacotherapy, 1994There remain several pharmacologic considerations relating to paclitaxel that are being, or need to be, explored. Some of the more important of these include the following issues: Further elaboration of the metabolic fate of paclitaxel. A multicenter study is currently being planned to determine the complete metabolic fate of paclitaxel, using ...
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