Results 101 to 110 of about 12,321 (161)

Pretubulysin: from hypothetical biosynthetic intermediate to potential lead in tumor therapy. [PDF]

, 2012
Pretubulysin is a natural product that is found in strains of myxobacteria in only minute amounts. It represents the first enzyme-free intermediate in the biosynthesis of tubulysins and undergoes post-assembly acylation and oxidation reactions ...
Uli Kazmaier (164323), Müller Rolf, Müller, Rolf, Angelika M. Vollmar (164324), Yasser A Elnakady, Rohde, Manfred, Elnakady Yasser A., Ullrich, Angelika, Rolf Müller, Angelika M. Vollmar, Angelika Ullrich (164321), Herrmann Jennifer, Vollmar, Angelika M, Romina M. Wiedmann, Manfred Rohde (61075), Wiedmann Romina M., Manfred Rohde, Rolf Müller (11963), Jennifer Herrmann, Jennifer Herrmann (152429), Vollmar, Angelika M., Angelika Ullrich, Romina M Wiedmann, Yasser A. Elnakady (164316), Rohde Manfred, Wiedmann, Romina M., Yasser A. Elnakady, Kazmaier Uli, Ullrich Angelika, Herrmann, Jennifer, Kazmaier, Uli, Vollmar Angelika M., Elnakady, Yasser A., Uli Kazmaier, Romina M. Wiedmann (164319), Elnakady, Yasser A, Wiedmann, Romina M, Angelika M Vollmar   +37 more
core   +1 more source

Gene expression and pathway analysis of ovarian cancer cells selected for resistance to cisplatin, paclitaxel, or doxorubicin

Journal of Ovarian Research, 2011
Background Resistance to current chemotherapeutic agents is a major cause of therapy failure in ovarian cancer patients, but the exact mechanisms leading to the development of drug resistance remain unclear.
Sherman-Baust Cheryl A, Becker Kevin G, Wood III William H, Zhang Yongqing, Morin Patrice J   +4 more
doaj   +1 more source

Studies on a strain of Kitasatospora sp. paclitaxel producer [PDF]

, 2000
The strain P&U 22869, which produces paclitaxel and related taxanes, discovered during the course of endophytic actinomycetes screening on Taxus baccata plants, was classified as Kitasatospora sp.
SARACCHI M., CARUSO M., CRESCPI-PERELLINO L., QUARONI S., FEDELI L., VENTRELLA G., COLOMBO A. L., MALYSZKO J., PAVESI A.   +8 more
core  

Integrated metabolomics and transcriptomics reveal mechanisms underlying high-yield accumulation of 10-deacetylbaccatin III, baccatin III, and 10-deacetyltaxol in Taxus mairei twigs

Industrial Crops and Products
Taxus renewable twigs produce valuable taxanes, notably anticancer drug paclitaxel and its key intermediates, including 10-deacetylbaccatin III (10DAB), baccatin III (B-III), and 10-deacetyltaxol (10DAT).
Liming Huang, Feifan Zhao, Xiangfei Fu, Bin Wang, Longjiang Yu, Chunhua Fu   +5 more
doaj   +1 more source

Should I stay or should I go? The fight or flight defense responses in Taxus cell culture [PDF]

, 2020
Taxus culture is the current system to commercially produce paclitaxel, a highly potent and valuable chemotherapeutic drug, although paclitaxel biosynthesis and other cellular processes within Taxus remain largely elusive.
McKee, Michelle C
core  

Editorial: Transgenesis and secondary metabolites: recent developments and technological challenges

Frontiers in Plant Science, 2023
Sumita Jha, Hengfu Yin, Chenghao Li, Guang-Long Wang   +3 more
doaj   +1 more source

Biotransormations with plant coenzyme A-dependent acyltransferases [PDF]

, 2008
The acylation of plant natural products is widely observed in nature and this modification often confers novel bioactivities. In nature, each of these acylations is selectively catalysed by a coenzyme A-dependent acyltransferase and biotransformations ...
Cunningham, Oliver David
core  

Transcriptomic and metabolomic analysis of yellow leaf mutant variation in Taxus cuspidata

Frontiers in Plant Science
During the cultivation of Taxus cuspidata, significant differences in leaf coloration between different types have emerged, which is of great significance for variety breeding.
Shuo Zhang, Duo Liu, Lihui Zhang, Yanwen Zhang   +3 more
doaj   +1 more source

Paclitaxel transporter characterization [PDF]

Paclitaxel is a valuable chemotherapeutic compound naturally produced by Taxus species, but its commercial production in plant cell culture systems remains limited by poor secretion efficiency.
Bray, Aili
core  

The effects of Fusarium graminearum cell extracts and culture filtrates on the production of paclitaxel and 10-deacetylbaccatin III in suspension cell cultures of Taxus baccata L.

BMC Plant Biology
Background The genus Taxus (yew) is the sole producer of the paclitaxel with anticancer properties. The rising demand for plant-derived medicines has led to the overexploitation of various species and ecosystem degradation, which is further worsened by ...
Arman Kamali Dehghan, Meisam Zargar, Mahsa Bamneshin, Mohtaram Mahmoudieh, Naser Safaie, Jun-Li Yang, Mohammad Reza Naghavi   +6 more
doaj   +1 more source