Results 91 to 100 of about 12,321 (161)
Paclitaxel: new insights into its regulation, biosynthesis and biotechnological production [PDF]
The emergency to obtain effective substances against cancer, and the awareness to protect natural resources make plant biofactories a promising alternative for obtaining plant-derived compounds.
Escrich Montañana, Ainoa
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Combinatorial biosynthesis of medicinal plant secondary metabolites [PDF]
, 2006 Combinatorial biosynthesis is a new tool in the generation of novel natural products and for the production of rare and expensive natural products. The basic concept is combining metabolic pathways in different organisms on a genetic level.
Woerdenbag, Herman J.; id_orcid +6 more
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, 2022 Taxol (Paclitaxel), tetraciklički diterpen, je sekundarni metabolit biljnog porijekla s antitumorskim svojstvima kojeg sintetiziraju stabla roda Taxus. Prvi put je izoliran iz kore biljke Taxus baccata početkom druge polovice 20.
Subota, Kristian
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Zeitschrift für Naturforschung C, 2008 The time-course of expression of dbat and dbtnbt genes involved in the later steps of paclitaxel biosynthesis and the intracellular taxane accumulation were investigated through a 64-day subculture interval of VI/M1 and VI/M2 Taxus baccata callus cultures.
Zuzana, Katkovcinová +4 more
openaire +2 more sources
Industrial Crops and ProductsTaxus yunnanensis has attracted considerable attention due to its richness in bioactive metabolites, such as paclitaxel and flavonoids, and artificial cultivation has become its primary source. However, the mechanisms by which irrigation amount regulates
Xiong Huang +11 more
doaj +1 more source
Evolutionary Developments in Plant Specialized Metabolism, Exemplified by Two Transferase Families
Frontiers in Plant Science, 2019 Plant specialized metabolism emerged from the land colonization by ancient plants, becoming diversified along with plant evolution. To date, more than 1 million metabolites have been predicted to exist in the plant kingdom, and their metabolic processes ...
Hiroaki Kusano +5 more
doaj +1 more source
Comparative Transcriptome Analysis Revealed the Tissue-Specific Accumulations of Taxanes among Three Experimental Lines of Taxus yunnanensis [PDF]
, 2018 Taxus yunnanensis (Yew) is known for natural anticancer metabolite paclitaxel (Taxol) and its biosynthesis pathway in yew species still needs to be completely elucidated. In the current study, productions of paclitaxel and 10-DAB III from three different
Qiao-ming Huang (5787551) +9 more
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In vitro wound healing of tumor cells: inhibition of cell migration by selected cytotoxic alkaloids
BMC Pharmacology and Toxicology, 2019 Background Cell migration is involved in several pathological processes such as tumor invasion, neoangiogenesis and metastasis. Microtubules are needed in directional migration. Methods To investigate the effects of microtubule-binding agents (paclitaxel,
Xiaojuan Wang +4 more
doaj +1 more source
Paclitaxel Biosynthesis AI Breakthrough
Paclitaxel, C47H51NO14, biosynthesis is an active area of research due to ongoing progress towards more sustainable and environmentally friendly production of the drug compound. Recent literature details the characterization of enzymes that play a role in synthesis, optimization of growth media, and RNA related regulatory mechanisms.
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Identification of transcription factors controlling the expression of paclitaxel biosynthesis genes in cambial meristematic cells of Taxus cuspidata [PDF]
, 2013 Paclitaxel is an antitumor diterpene from Taxus spp. that binds tubulin, stabilizes microtubules and induces apoptosis in dividing human cells. It was originally isolated from the bark of Taxus brevifolia and approved for clinic uses by the FDA in ...
Yan, Zejun Jun
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