Results 91 to 100 of about 291,802 (171)

Integrated physiological and multi-omics analyses revealed the response mechanisms of Taxus yunnanensis to varying irrigation amounts

Industrial Crops and Products
Taxus yunnanensis has attracted considerable attention due to its richness in bioactive metabolites, such as paclitaxel and flavonoids, and artificial cultivation has become its primary source. However, the mechanisms by which irrigation amount regulates
Xiong Huang, Mengke Dou, Wenjing Miu, Cheng Huang, Jiangtao Fan, Fuhua Zhu, Feng Xie, Zhi Xie, Pengpeng Gong, Jialan Su, Hongrui Lu, Zhipeng Sun   +11 more
doaj   +1 more source

Weekly Paclitaxel Versus Three-Weekly Paclitaxel in Recurrent Platinum-Resistant Epithelial Ovarian and Peritoneal Cancers: A Phase III Study

, 2016
Introduction Treatment of recurrent platinum-resistant ovarian and peritoneal cancers represents a therapeutic challenge. The aim of this Phase III prospective study was to compare the survival benefits, objective response rate, and toxicities among ...
Mohammed A. Osman, Khalid E. Nasr, Mohammad S. Elkady   +2 more
core   +1 more source

Evolutionary Developments in Plant Specialized Metabolism, Exemplified by Two Transferase Families

Frontiers in Plant Science, 2019
Plant specialized metabolism emerged from the land colonization by ancient plants, becoming diversified along with plant evolution. To date, more than 1 million metabolites have been predicted to exist in the plant kingdom, and their metabolic processes ...
Hiroaki Kusano, Hao Li, Hiroshi Minami, Yoshihiro Kato, Homare Tabata, Kazufumi Yazaki   +5 more
doaj   +1 more source

Identification and characterization of key regulators of Paclitaxel Biosynthesis in Taxus cuspidata

, 2014
Numerous drugs in the current pharmacopoeia originate from plant sources. Plant cell culture represents an alternative source for producing high-value secondary metabolites including paclitaxel.
Amir, Rabia
core  

Paclitaxel Biosynthesis AI Breakthrough

Paclitaxel, C47H51NO14, biosynthesis is an active area of research due to ongoing progress towards more sustainable and environmentally friendly production of the drug compound. Recent literature details the characterization of enzymes that play a role in synthesis, optimization of growth media, and RNA related regulatory mechanisms.
openaire   +1 more source

In vitro wound healing of tumor cells: inhibition of cell migration by selected cytotoxic alkaloids

BMC Pharmacology and Toxicology, 2019
Background Cell migration is involved in several pathological processes such as tumor invasion, neoangiogenesis and metastasis. Microtubules are needed in directional migration. Methods To investigate the effects of microtubule-binding agents (paclitaxel,
Xiaojuan Wang, Charlotte Caroline Decker, Laura Zechner, Sonja Krstin, Michael Wink   +4 more
doaj   +1 more source

Genome-wide identification and expression pattern analysis of NAC family in Taxus yunnanensis and the TyuNAC30 role in paclitaxel production

BMC Genomics
Background The NAC transcription factor family represents a large group of plant-specific genes involved in various biological processes, including secondary metabolite biosynthesis, responses to biotic and abiotic stresses, and hormone signaling.
Jiangtao Fan, Yong Wang, Mengke Dou, Qiuhong Hu, Qing Li, Shengmei Gan, Mingwei Jing, Gang Wang, Xiong Huang   +8 more
doaj   +1 more source

Designing an oxidase toolbox for site-directed oxidation of taxanes

Nature Communications
Paclitaxel is one of the most prominent drugs for cancer therapy, and its synthesis has long been pursued by scientific community. Although the biosynthetic pathway has been gradually unraveled, its synthetic efficiency remains severely constrained by ...
Mingyuan Lai, Yu Weng, Jian Wei, Xin-Yi Lu, Zhengyu Huang, Hangcheng Li, Longhao Huang, Zhijun Zhang, Lili Zhu, Jian-He Xu, Ran Hong, Hui-Lei Yu   +11 more
doaj   +1 more source

Integrated metabolomics and transcriptomics reveal mechanisms underlying high-yield accumulation of 10-deacetylbaccatin III, baccatin III, and 10-deacetyltaxol in Taxus mairei twigs

Industrial Crops and Products
Taxus renewable twigs produce valuable taxanes, notably anticancer drug paclitaxel and its key intermediates, including 10-deacetylbaccatin III (10DAB), baccatin III (B-III), and 10-deacetyltaxol (10DAT).
Liming Huang, Feifan Zhao, Xiangfei Fu, Bin Wang, Longjiang Yu, Chunhua Fu   +5 more
doaj   +1 more source

Chemical Inhibitors Suggest Endophytic Fungal Paclitaxel Is Derived from Both Mevalonate and Non-mevalonate-like Pathways

, 2016
Taxus trees possess fungal endophytes reported to produce paclitaxel. Inhibitors that block early steps in plant paclitaxel biosynthesis were applied to a paclitaxel-producing fungus to determine whether these steps are shared.
Rong Tsao (52985), Manish N. Raizada (218573), Sameh S. M. Soliman (2133694)   +2 more
core   +1 more source