Results 71 to 80 of about 291,802 (171)

Transcriptome and comparative chloroplast genome analysis of Taxus yunnanensis individuals with high and low paclitaxel yield

Heliyon
Paclitaxel is a potent anti-cancer drug that is mainly produced through semi-synthesis, which still requires plant materials as precursors. The content of paclitaxel and 10-deacetyl baccatin III (10-DAB) in Taxus yunnanensis has been found to differ from
Dong Wang, Jiansheng Wei, Xiaolong Yuan, Zhonghua Chen, Lei Wang, Yunfen Geng, Jinfeng Zhang, Yi Wang   +7 more
doaj   +1 more source

Comparative metabolomic analysis reveals the variations in taxoids and flavonoids among three Taxus species

BMC Plant Biology, 2019
Background Trees of the genus Taxus are highly valuable medicinal plants with multiple pharmacological effects on various cancer treatments. Paclitaxel from Taxus trees is an efficient and widely used anticancer drug, however, the accumulation of taxoids
Ting Zhou, Xiujun Luo, Chengchao Zhang, Xinyun Xu, Chunna Yu, Zhifang Jiang, Lei Zhang, Huwei Yuan, Bingsong Zheng, Erxu Pi, Chenjia Shen   +10 more
doaj   +1 more source

AI‐Driven Rational Design of Nanotherapeutics for Pancreatic Ductal Adenocarcinoma

Medicinal Research Reviews, EarlyView.
ABSTRACT Pancreatic ductal adenocarcinoma (PDAC) remains a formidable malignancy characterized by late diagnosis, high recurrence rates, and pronounced chemoresistance. While nanoparticle‐based drug delivery systems (NDDS) offer theoretical advantages over conventional therapies, their clinical translation in PDAC has been severely limited.
Seohyun Choo, Kaeun Chae, Jueun Lee, Inseon Kim, Seunghun S. Lee   +4 more
wiley   +1 more source

Bioactive Natural Products in Cardiovascular Disease: Focus on Thrombotic Events

Phytotherapy Research, EarlyView.
An overview of the role of natural products (NP) in cardiovascular disease prevention, highlighting key mechanisms of action: including antiplatelet, antithrombotic, anti‐inflammatory, and antioxidant effects. Additionally, it illustrates the integration of diet–drug interactions, nutritional epigenetics, and the role of artificial intelligence in ...
Maria Nektaria Magkoulia, Despoina Pantazi   +1 more
wiley   +1 more source

Mesenchymal Stromal Cells Used for Carrying and Delivering Paclitaxel

, 2013
Paclitaxel is an antimitotic drug that promotes microtubule polymerization and produces sensitization to radiation. Paclitaxel is a first-line drug for the treatment of non-small cell lung cancer and is used to treat metastatic ovarian cancer, breast ...
PASCUCCI, Luisa, Augusto Pessina, Emilio Ciusani, Giulio Alessandri, Eugenio Parati, Arianna Bonomi   +5 more
core  

Paclitaxel-treated siSBF2 cells reveal candidate genes exclusive to this group.

, 2022
A) Volcano plot of the comparison between vehicle-treated NTC and siSBF2 cells. 15,271 differentially expressed genes were detected in the analysis, with SBF2 being the only gene that reached statistical significance (FDR = 0.002, logFC = -1.60.) B ...
Jill C. Fehrenbacher (11909909), Xi Wu (128938), Bryan P. Schneider (9710008), Yunlong Liu (46477), Jun Wan (126294), Laura Gardner (5503388), Geneva M. Cunningham (11909900), Erica L. Cantor (11909903), Zhiyong Tan (6172586), Santosh Philips (4489522), Guanglong Jiang (3469451), Casey L. Bales (11909906), Fei Shen (348351)   +12 more
core   +1 more source

Cell‐Based Micro/Nanorobots: From Living Carriers to Living Therapeutic Specialists

SmartBot, EarlyView.
Cell‐based micro/nanorobots integrate evolutionarily acquired biological intelligence with engineered capabilities, offering new opportunities for precision medicine in vivo. However, the complex physiological environments of different organs pose significant challenges to their clinical translation.
Junfeng Wu, Zhaoyu Zhang, Ke Xu, Enkuo Li, Yuting Cui, Yuting Zhou, Huanyu Zhou, Beipei Zhang, Shuai Jiang, Xiaodong Wang, Jialin Jiang, Lianqing Liu, Niandong Jiao   +12 more
wiley   +1 more source

Bacteriophage P22 Virus‐Like Particles as Nanoscale Protein Scaffolds for Plant Synthetic Biology

Plant Biotechnology Journal, EarlyView.
ABSTRACT Advancing the utility of plant synthetic biology requires the continued development of protein engineering tools. Self‐assembling protein compartments, such as virus‐like particles (VLPs), provide versatile scaffolds for synthetic biology. However, few plant‐expressed VLPs have demonstrated broad amenability to protein engineering, restricting
Maxim D. Harding, Mark A. Jackson, Edward K. Gilding, David J. Craik, Frank Sainsbury, Nicole Lawrence   +5 more
wiley   +1 more source

Enhancing the biosynthesis of taxadien-5α-yl-acetate in Escherichia coli by combinatorial metabolic engineering approaches

Bioresources and Bioprocessing
Biosynthesis of paclitaxel (Taxol™) is a hot topic with extensive and durable interests for decades. However, it is severely hindered due to the very low titers of intermediates.
Wen-Liang Xie, Mei-Fang Zhang, Zheng-Yu Huang, Man Xu, Chun-Xiu Li, Jian-He Xu   +5 more
doaj   +1 more source

The role of extracellular vesicles in cell–cell crosstalk in cardiotoxicity

The Journal of Physiology, EarlyView.
Abstract figure legend Administration of a pharmacological agent can result in off‐target cardiotoxicity which can be driven by cell–cell crosstalk between healthy and dysfunctional cardiac cells. Extracellular vesicles (EVs) are lipid bilayer structures that can move biological cargo between cells, facilitating cell–cell crosstalk.
Gabriella Bachynskyj‐Bilas, Debbie J. Otto, Daniel Stratton, Katja Rietdorf, Daniel M. Johnson, Calum J. McMullen   +5 more
wiley   +1 more source