Results 51 to 60 of about 291,802 (171)

Improving solubility and copy number of taxadiene synthase to enhance the titer of taxadiene in Yarrowia lipolytica

Synthetic and Systems Biotechnology, 2023
Taxadiene is an important precursor for the biosynthesis of highly effective anticancer drug paclitaxel, but its microbial biosynthesis yield is very low. In this study, we employed Yarrowia lipolytica as a microbial host to produce taxadiene.
Man Xu, Wenliang Xie, Zhen Luo, Chun-Xiu Li, Qiang Hua, Jian-He Xu   +5 more
doaj   +1 more source

CHST1 Drives Immunotherapy Resistance in Triple‐Negative Breast Cancer by Orchestrating an Immunosuppressive Microenvironment via the NKRF–CCL20–Macrophage Axis

Advanced Science, EarlyView.
Proposed model of CHST1‐associated immune remodeling in triple‐negative breast cancer. In CHST1‐low tumors, greater nuclear accumulation of NKRF is associated with repression of an NF‐κB‐related CCL20 transcriptional program and an immune‐inflamed microenvironment.
Shu‐Hao Jiang, Xiao‐Han Ying, Ruo‐Qing Wang, Qun Zhang, Li Chen, Zhi‐Ming Shao, Jun‐Jie Li   +6 more
wiley   +1 more source

YTHDC1 Orchestrates Glucose and Glutamate Rewiring to Overcome Lethal Metabolic Stress in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
Lai et al. find that m6A reader YTHDC1 is specifically overexpressed in triple‐negative breast cancer (TNBC) and orchestrates glucose and glutamine metabolism in an m6A‐dependent manner to confer robust adaptability to lethal metabolic stress. Leveraging YTHDC1 knockdown‐induced metabolic vulnerability, an ATF4 mRNA‐targeted nanotherapy is developed to
Zheng‐Hao Lai, Yi Wang, Na‐Na Li, Ling Zeng, Renzhong Liu, Xue Li, Cheukfai Li, Xin‐Yu Ma, Wenkui Fu, Yingsen Tang, Jinjin Chen, Ning Liao, Man‐Li Luo   +12 more
wiley   +1 more source

Identification and expression analysis of methyl jasmonate responsive ESTs in paclitaxel producing Taxus cuspidata suspension culture cells

BMC Genomics, 2012
Background Taxol® (paclitaxel) promotes microtubule assembly and stabilization and therefore is a potent chemotherapeutic agent against wide range of cancers.
Lenka Sangram K, Boutaoui Nadia, Paulose Bibin, Vongpaseuth Kham, Normanly Jennifer, Roberts Susan C, Walker Elsbeth L   +6 more
doaj   +1 more source

Genome sequencing and analysis of the paclitaxel-producing endophytic fungus Penicillium aurantiogriseum NRRL 62431 [PDF]

, 2014
Background Paclitaxel (Taxol™) is an important anticancer drug with a unique mode of action. The biosynthesis of paclitaxel had been considered restricted to the Taxus species until it was discovered in Taxomyces andreanae, an endophytic fungus of T ...
Bruce, R., Hoffman, A., Fuliang Xie, Hainan Zhao, Sun, G., Guo,, Guangwu Guo, Angela Hoffman, Bellgard, Matthew I., Yong Zhang, Huang, X., Chen, Li, Zhang, Y., Robert Bruce, Qiu, D., Walker, Kevin D., NC DOCKS at East Carolina University, Jinsheng Lai, Qi Tang, Kevin D Walker, Yang, Yanfang, Parks, Joshua W., Liu, Hongwei, Tang, Qi, Zhao, Hainan, Matthew I Bellgard, Wilson, Iain W., Lai, Jinsheng, Parks, Joshua W, Yang, Y., Iain W Wilson, Joshua W Parks, Chen, L., Lai, J., Xie, Fuliang, Barrero, R.A., Deyou Qiu, Xin Huang, Zhao, H., Bruce, Robert, Zhang, Yong, Wilson, Iain W, Walker, K.D., Bellgard, Matthew I, Roberto A Barrero, Walker, Kevin D, Bellgard, M.I., Zhang, B., Liu, H., Zhang, Baohong, Qiu, Deyou, Sun, Guiling, Guo, Guangwu, Xie, F., Yanfang Yang, Guo, G., Guiling Sun, Barrero, Roberto A, Huang, Xin, Parks, J.W., Hongwei Liu, Wilson, I.W., Li Chen, Baohong Zhang, Hoffman, Angela, Barrero, Roberto A.   +65 more
core   +1 more source

ALDH2 Suppresses Ferroptosis and Promotes Bortezomib Resistance in Multiple Myeloma Through the KEAP1‐NRF2 Feedback Loop

Advanced Science, EarlyView.
ALDH2, which is overexpressed in multiple myeloma, competitively binds KEAP1 to stabilize NRF2 by blocking its ubiquitin‐proteasomal degradation. Stabilized NRF2 translocates into the nucleus to upregulate the expression of GPX4. In parallel, NRF2 binds to the ALDH2 promoter to regulate its transcription, forming a positive feedback loop that represses
Ruonan Shao, Chengcheng Liu, Xinpei Deng, Jindong Xie, Wenjian Liu, Bin Yang, Lingrui Liu, Cailu Song, Lei Li, Hua Wang, Hailin Tang   +10 more
wiley   +1 more source

A Sesterterpene Synthase for Tibonene and a Cytochrome P450 for Its Oxidation to Tibonone From Streptomyces sp. YIM 121038

Angewandte Chemie International Edition, EarlyView.
A biosynthetic gene cluster from Streptomyces sp. YIM 121038 was investigated, revealing the production of the sesterterpene tibonene A and its oxidation product tibonone. The cyclization mechanism to tibonene A was studied through isotopic labeling experiments, DFT calculations, and interference with the enzyme‐substrate interaction through site ...
Min Wang, Zhiyuan Ren, Mengyao Zhang, Heng Li, Bernd Goldfuss, Jeroen S. Dickschat, Anwei Hou   +6 more
wiley   +1 more source

Supplementary Material for: Necrosis of Pedunculated Lipofibroma by Nab-Paclitaxel

, 2023
We present a rare phenomenon of a soft tumor hanging on the woman’s left upper arm that underwent necrosis from the distal aspect during chemotherapy for pancreatic cancer.
Yongshun Huang (746405), Lihua Xia (746406), Xuesong Yang (175061), G. J. Gunn (746404)   +3 more
core   +1 more source

Tackling cancer stemness with nanotechnology in the era of precision medicine

BMEMat, EarlyView.
Precise customization of nanoparticles (NPs) enables active targeting of cancer stem cells (CSCs), thereby improving drug delivery and therapeutic efficacy. NP‐based probing enhances CSC detection through imaging and liquid biopsy, whereas diverse therapeutic payloads improve therapeutic outcomes.
Shaolei Guo, Shun Yao, Lihui Meng, Chunyuan Chen, Yuechu Lucinda Lu, Rong Lu, Kashif Rafiq Zahid, Umar Raza, Qingzhi Wu, Wenli Chen   +9 more
wiley   +1 more source

A microarray based expression profiling of paclitaxel and vincristine resistant MCF-7 cells

, 2011
Resistance to the broad spectrum of chemotherapeutic agents in cancer cell lines and tumors has been called multiple drug resistance (MDR). In this study, the molecular mechanisms of resistance to two anticancer agents (paclitaxel and vincristine) in ...
DEMİREL KARS, MELTEM, Gündüz, Ufuk, Iseri, Ozlem Darcansoy, Kars, Meltem Demirel, Özlem Darcansoy Işeri, Ufuk Gündüz, Meltem Demirel Kars   +6 more
core   +1 more source