Results 51 to 60 of about 12,321 (161)

Cholesterol‐Mediated Metabolic‐mechanotransductive Crosstalk Orchestrates Castration Resistance in Prostate Cancer

Advanced Science, EarlyView.
Full androgen deprivation (FAD) induces paracrine cholesterol in prostate cancer that drives the polarization of cancer‐associated fibroblasts (CAFs) and subsequent elevated matrix stiffness. Matrix stiffness in turn potentiates tumor cell survival under FAD pressure via dual mechanotransductive activation of the IRE1α‐XBP1s stress‐response axis ...
Shaojie Liu, Chao Xu, Jun Jiang, Limin He, Yike Zhou, Zhengxuan Li, Yu Li, Keying Zhang, Fa Yang, Tong Lu, Hongtao Song, Hai Zhu, Zhihao Hu, Xiaolong Zhao, Kai Gan, Hongji Li, Bo Yang, Rui Zhang, Weihong Wen, Donghui Han, Weijun Qin   +20 more
wiley   +1 more source

Metabolic engineering strategies to enhance the production of anticancer drug, paclitaxel [PDF]

, 2021
Paclitaxel, an important diterpenoid with a taxane skeleton, is isolated from Taxus species (yew tree), and used as a component of anticancer drugs. The U.S Food and Drug Administration (FDA) has approved paclitaxel for treating many cancer types, such ...
Mallappa Kumara Swamy, Sasanala Shamili, Satish, Lakkakula, Dhanarajan, Malli Subramanian, Manikandan Ramesh, Prasanth, Kakarla, Kakarla Prasanth, Yolcu Seher, Lakkakula Satish, Shamili, Sasanala, Alavilli Hemasundar, Ramesh, Manikandan, Kasinathan Rakkammal, Rakkammal, Kasinathan, Muthuramalingam, Pandiyan, Lakshmi, Chavakula Rajya, Yolcu, Seher, Malli Subramanian Dhanarajan, Swamy, Mallappa Kumara, Hemasundar, Alavilli, Pandiyan Muthuramalingam, Chavakula Rajya Lakshmi   +21 more
core   +1 more source

Mesenchymal Stromal Cells Used for Carrying and Delivering Paclitaxel [PDF]

, 2013
Paclitaxel is an antimitotic drug that promotes microtubule polymerization and produces sensitization to radiation. Paclitaxel is a first-line drug for the treatment of non-small cell lung cancer and is used to treat metastatic ovarian cancer, breast ...
PASCUCCI, Luisa, Augusto Pessina, Emilio Ciusani, Giulio Alessandri, Eugenio Parati, Arianna Bonomi   +5 more
core  

Multi‐Omics Profiling of High‐Grade Serous Ovarian Cancer Reveals an Inflammation‐Related Lipid Metabolism Subtype Associated With Platinum Resistance

Advanced Science, EarlyView.
Through integrated proteomic and metabolomic profiling, Zhao et al. identified three molecular subtypes of high‐grade serous ovarian cancer. The high‐risk subtype exhibits activated arachidonic acid metabolism and cyclooxygenase‐2 overexpression. This metabolic axis promotes M2‐like macrophage infiltration, which contributes to platinum resistance ...
Yuxi Zhao, Junyi Li, Bo Zheng, Wanshan Liu, Yaru Wang, Shufeng Wang, Ying Cui, Huiqin Guo, Hongxia Wang, Ting Xiao, Kun Qian, Jing Zuo   +11 more
wiley   +1 more source

Tackling cancer stemness with nanotechnology in the era of precision medicine

BMEMat, EarlyView.
Precise customization of nanoparticles (NPs) enables active targeting of cancer stem cells (CSCs), thereby improving drug delivery and therapeutic efficacy. NP‐based probing enhances CSC detection through imaging and liquid biopsy, whereas diverse therapeutic payloads improve therapeutic outcomes.
Shaolei Guo, Shun Yao, Lihui Meng, Chunyuan Chen, Yuechu Lucinda Lu, Rong Lu, Kashif Rafiq Zahid, Umar Raza, Qingzhi Wu, Wenli Chen   +9 more
wiley   +1 more source

Mitochondria‐endoplasmic reticulum organelle glue as maturation promoter for origination/dimensional dual‐cross cardiomyocytes

BMEMat, EarlyView.
Mitochondria‐endoplasmic reticulum contact sites (MERCS) are areas where the mitochondria and endoplasmic reticulum closely interact. In this study, we utilize synthetic organelle glues to artificially engineer MERCS for regulating cardiomyocyte development, through which the immature and chemo‐plasticity issues of undifferentiated cells are addressed.
Wei Tang, Hao Sun, Chenqi Duan, Jiajia Chang, Yuxing Wang, Ming Zhao, Huiyue Zhao, Shan Lu, Yang Yang, Da Huo   +9 more
wiley   +1 more source

Exploring transcriptional regulation during methyl jasmonate elicitation of paclitaxel in cultured Taxus cuspidata cambial meristematic cells [PDF]

, 2016
Plants produce a wide variety of natural products that can be exploited for medicinal purposes. Paclitaxel is a key anti-cancer drug originally isolated from the bark of Taxus spp. that is currently approved for use in the treatment of breast, lung and
Howat, Susan Ann
core   +1 more source

DNA Methylation and Transcriptomic Profiles of Wilms Tumour Reveal New Deregulated Genes and Epigenetic Processes Relevant for Tumour Stratification and Management

International Journal of Cancer, EarlyView.
ABSTRACT Wilms Tumour (WT), the most common kidney cancer in children, presents features of altered kidney development and frequently exhibits molecular alterations at the 11p15.5 imprinted locus, affecting the IGF2 and H19 genes, which contribute to tumour growth and predisposition.
Abu Saadat, Francesco Cecere, Federica Rossetti, Laura Pignata, Emilia D'Angelo, Carlo Giaccari, Gaetano Verde, Paola Quarello, Franca Fagioli, Josep Roma, Manel Esteller, Enrique de Álava, Flavia Cerrato, Andrea Riccio, Angela Sparago   +14 more
wiley   +1 more source

Genome sequencing and analysis of the paclitaxel-producing endophytic fungus Penicillium aurantiogriseum NRRL 62431 [PDF]

, 2014
Background Paclitaxel (Taxol™) is an important anticancer drug with a unique mode of action. The biosynthesis of paclitaxel had been considered restricted to the Taxus species until it was discovered in Taxomyces andreanae, an endophytic fungus of T ...
Bruce, R., Hoffman, A., Fuliang Xie, Hainan Zhao, Sun, G., Guo,, Guangwu Guo, Angela Hoffman, Bellgard, Matthew I., Yong Zhang, Huang, X., Chen, Li, Zhang, Y., Robert Bruce, Qiu, D., Walker, Kevin D., NC DOCKS at East Carolina University, Jinsheng Lai, Qi Tang, Kevin D Walker, Yang, Yanfang, Parks, Joshua W., Liu, Hongwei, Tang, Qi, Zhao, Hainan, Matthew I Bellgard, Wilson, Iain W., Lai, Jinsheng, Parks, Joshua W, Yang, Y., Iain W Wilson, Joshua W Parks, Chen, L., Lai, J., Xie, Fuliang, Barrero, R.A., Deyou Qiu, Xin Huang, Zhao, H., Bruce, Robert, Zhang, Yong, Wilson, Iain W, Walker, K.D., Bellgard, Matthew I, Roberto A Barrero, Walker, Kevin D, Bellgard, M.I., Zhang, B., Liu, H., Zhang, Baohong, Qiu, Deyou, Sun, Guiling, Guo, Guangwu, Xie, F., Yanfang Yang, Guo, G., Guiling Sun, Barrero, Roberto A, Huang, Xin, Parks, J.W., Hongwei Liu, Wilson, I.W., Li Chen, Baohong Zhang, Hoffman, Angela, Barrero, Roberto A.   +65 more
core   +1 more source

Baseline survey of root-associated microbes of Taxus chinensis (Pilger) Rehd. [PDF]

PLoS ONE, 2015
Taxol (paclitaxel) a diterpenoid is one of the most effective anticancer drugs identified. Biosynthesis of taxol was considered restricted to the Taxus genera until Stierle et al.
Qian Zhang, Hongwei Liu, Guiling Sun, Iain W Wilson, Jianqiang Wu, Angela Hoffman, Junwen Cheng, Deyou Qiu   +7 more
doaj   +1 more source