Results 41 to 50 of about 12,321 (161)

Paclitaxel: biosynthesis, production and future prospects

New Biotechnology, 2014
Plants are capable of producing a wide variety of secondary metabolites which have a diverse range of functions that can be exploited for medicinal purposes; for example, paclitaxel is a major anti-cancer drug found in the bark of Taxus spp. There are however supply issues as the compound is only found at low concentrations (0.05%) within the plant ...
Susan, Howat, Bora, Park, Il Suk, Oh, Young-Woo, Jin, Eun-Kyong, Lee, Gary J, Loake   +5 more
openaire   +2 more sources

List of selected unigenes involved in paclitaxel biosynthesis. [PDF]

, 2014
List of selected unigenes involved in paclitaxel biosynthesis.
Dan Qian (343850), Fei Qiao (198706), Rongxiang Wang (627367), Hanqing Cong (627365), Junmei Yin (627368), Zhunian Wang (627369), Xuefei Jiang (627366), Peter Nick (152570)   +7 more
core   +1 more source

Genes in main chain of terpenoid backbone biosynthesis and paclitaxel biosynthesis with changes in transcript abundance. [PDF]

, 2013
For the genes in paclitaxel biosynthesis, only genes with more than 90% identity with reported genes are shown. “n.d.” indicates that the estimated relative abundance is zero in the nonelicited culture.
Fuliang Xie (197367), Jian-Fan Wen (160083), Yanfang Yang (408813), Hongwei Liu (80414), Iain W. Wilson (408815), Deyou Qiu (408816), Jianqiang Wu (408814), Qi Tang (351973), Guiling Sun (174767)   +8 more
core   +1 more source

Prioritization Strategy and Engineering Optimization for Paclitaxel Biosynthesis: From Pathway Analysis to Synthetic Biology [PDF]

BIO Web of Conferences
Paclitaxel, one of the most widely used natural anticancer drugs in clinical treatment, plays a significant role across medicine, public health, and even the economic sphere.
Lin Junkang
doaj   +1 more source

Microbial Cell Factory of Baccatin III Preparation in Escherichia coli by Increasing DBAT Thermostability and in vivo Acetyl-CoA Supply

Frontiers in Microbiology, 2022
Given the rapid development of genome mining in this decade, the substrate channel of paclitaxel might be identified in the near future. A robust microbial cell factory with gene dbat, encoding a key rate-limiting enzyme 10-deacetylbaccatin III-10-O ...
Jia-jun Huang, Jia-jun Huang, Tao Wei, Tao Wei, Zhi-wei Ye, Zhi-wei Ye, Qian-wang Zheng, Qian-wang Zheng, Bing-hua Jiang, Wen-feng Han, Wen-feng Han, An-qi Ye, An-qi Ye, Pei-yun Han, Pei-yun Han, Li-qiong Guo, Li-qiong Guo, Jun-fang Lin, Jun-fang Lin   +18 more
doaj   +1 more source

Transcriptomics and Physiological Analyses Reveal Changes in Paclitaxel Production and Physiological Properties in Taxus cuspidata Suspension Cells in Response to Elicitors

Plants, 2023
In this research, the cell growth, physiological, and biochemical reactions, as well as the paclitaxel production, of Taxus cuspidata suspension cells after treatment with polyethylene glycol (PEG), cyclodextrin (CD), or salicylic acid (SA) (alone or in ...
Zirui Zhao, Yajing Zhang, Wenlong Li, Yuanhu Tang, Shujie Wang   +4 more
doaj   +1 more source

Analysis of exosomal competing endogenous RNA network response to paclitaxel treatment reveals key genes in advanced gastric cancer

Frontiers in Oncology, 2022
BackgroundExosome is an important component of the tumor immune microenvironment and plays critical role in cancer pathogenesis. The exosome transcriptome of gastric cancer (GC) response to paclitaxel chemotherapy has not been investigated in the past ...
Jun Lei, Guifeng Zhang, Deyu Li, Jiangming Zhong, Qiao Chen, Li Lin, Zhenhua Liu   +6 more
doaj   +1 more source

4-Deacetylbaccatin III: A Proposed Biosynthetic Precursor of Paclitaxel from the Bark of

Natural Product Communications, 2010
4-Deacetylbaccatin III was isolated and characterized from the bark of Taxus wallichiana Zucc. It was previously identified as an intermediate during the synthesis of paclitaxel and was proposed as a precursor for the biosynthesis of paclitaxel ...
Muhammad Nisar, Mughal Qayum, Achyut Adhikari, Inamullah Khan, Waqar Ahamad Kaleem, Zulfiqar Ali, M. Iqbal Choudhary   +6 more
doaj   +1 more source

RNA-seq and integrated network analysis reveals the hub genes and key pathway of paclitaxel inhibition on Adriamycin resistant diffuse large B cell lymphoma cells [PDF]

, 2022
About 40% of patients with diffuse large B-cell lymphoma (DLBCL) develop drug resistance after first-line chemotherapy, which remains a major cause of morbidity and mortality. The emergence of DLBCL drug resistance is mainly related to Adriamycin.
Haoyuan Hong (11386067), Zhigang Peng (5133335), Yingying Qin (461118), Bin Luo (303443), Sizhu Li (9454094)   +4 more
core   +1 more source

Improving solubility and copy number of taxadiene synthase to enhance the titer of taxadiene in Yarrowia lipolytica

Synthetic and Systems Biotechnology, 2023
Taxadiene is an important precursor for the biosynthesis of highly effective anticancer drug paclitaxel, but its microbial biosynthesis yield is very low. In this study, we employed Yarrowia lipolytica as a microbial host to produce taxadiene.
Man Xu, Wenliang Xie, Zhen Luo, Chun-Xiu Li, Qiang Hua, Jian-He Xu   +5 more
doaj   +1 more source