Results 41 to 50 of about 291,802 (171)

Microbial Cell Factory of Baccatin III Preparation in Escherichia coli by Increasing DBAT Thermostability and in vivo Acetyl-CoA Supply

Frontiers in Microbiology, 2022
Given the rapid development of genome mining in this decade, the substrate channel of paclitaxel might be identified in the near future. A robust microbial cell factory with gene dbat, encoding a key rate-limiting enzyme 10-deacetylbaccatin III-10-O ...
Jia-jun Huang, Jia-jun Huang, Tao Wei, Tao Wei, Zhi-wei Ye, Zhi-wei Ye, Qian-wang Zheng, Qian-wang Zheng, Bing-hua Jiang, Wen-feng Han, Wen-feng Han, An-qi Ye, An-qi Ye, Pei-yun Han, Pei-yun Han, Li-qiong Guo, Li-qiong Guo, Jun-fang Lin, Jun-fang Lin   +18 more
doaj   +1 more source

Transcriptomics and Physiological Analyses Reveal Changes in Paclitaxel Production and Physiological Properties in Taxus cuspidata Suspension Cells in Response to Elicitors

Plants, 2023
In this research, the cell growth, physiological, and biochemical reactions, as well as the paclitaxel production, of Taxus cuspidata suspension cells after treatment with polyethylene glycol (PEG), cyclodextrin (CD), or salicylic acid (SA) (alone or in ...
Zirui Zhao, Yajing Zhang, Wenlong Li, Yuanhu Tang, Shujie Wang   +4 more
doaj   +1 more source

List of selected unigenes involved in paclitaxel biosynthesis.

, 2014
List of selected unigenes involved in paclitaxel biosynthesis.
Dan Qian (343850), Fei Qiao (198706), Rongxiang Wang (627367), Hanqing Cong (627365), Junmei Yin (627368), Zhunian Wang (627369), Xuefei Jiang (627366), Peter Nick (152570)   +7 more
core   +1 more source

Confocal Raman data analysis enables identifying apoptosis of MCF-7 cells caused by anticancer drug paclitaxel [PDF]

, 2013
Confocal Raman microscopy is a noninvasive, label-free imaging technique used to study apoptosis of live MCF-7 cells. The images are based on Raman spectra of cells components, and their apoptosis is monitored through diffusion of cytochrome c in ...
Salehi, Hamideh, Collard Dutilleul, Pierre-Yves, Ramakrishnan, Satish, Middendorp, Elodie, Panayotov, Ivan, Dutilleul, Pierre-Yves Collart, Gergely, Csilla, Cuisinier, Frédéric J. G., Végh, Attila Gergely   +8 more
core   +1 more source

Paclitaxel and cancer treatment: Non-mitotic mechanisms of paclitaxel action in cancer therapy

, 2022
Paclitaxel (trade name Taxol) is a key drug used in chemotherapy for many solid tumors including ovarian, breast, lung, and prostate cancer. In the current treatment of ovarian cancer, paclitaxel is used as a frontline agent in combination with cisplatin
Xu, Xiang-Xi, Elizabeth R. Smith, Xiang-Xi Xu, Smith, Elizabeth R., Chen, Zhe-Sheng, Zhe-Sheng Chen   +5 more
core   +1 more source

Analysis of exosomal competing endogenous RNA network response to paclitaxel treatment reveals key genes in advanced gastric cancer

Frontiers in Oncology, 2022
BackgroundExosome is an important component of the tumor immune microenvironment and plays critical role in cancer pathogenesis. The exosome transcriptome of gastric cancer (GC) response to paclitaxel chemotherapy has not been investigated in the past ...
Jun Lei, Guifeng Zhang, Deyu Li, Jiangming Zhong, Qiao Chen, Li Lin, Zhenhua Liu   +6 more
doaj   +1 more source

4-Deacetylbaccatin III: A Proposed Biosynthetic Precursor of Paclitaxel from the Bark of

Natural Product Communications, 2010
4-Deacetylbaccatin III was isolated and characterized from the bark of Taxus wallichiana Zucc. It was previously identified as an intermediate during the synthesis of paclitaxel and was proposed as a precursor for the biosynthesis of paclitaxel ...
Muhammad Nisar, Mughal Qayum, Achyut Adhikari, Inamullah Khan, Waqar Ahamad Kaleem, Zulfiqar Ali, M. Iqbal Choudhary   +6 more
doaj   +1 more source

Genes in main chain of terpenoid backbone biosynthesis and paclitaxel biosynthesis with changes in transcript abundance.

, 2013
For the genes in paclitaxel biosynthesis, only genes with more than 90% identity with reported genes are shown. “n.d.” indicates that the estimated relative abundance is zero in the nonelicited culture.
Fuliang Xie (197367), Jian-Fan Wen (160083), Yanfang Yang (408813), Hongwei Liu (80414), Iain W. Wilson (408815), Deyou Qiu (408816), Jianqiang Wu (408814), Qi Tang (351973), Guiling Sun (174767)   +8 more
core   +1 more source

Expression of Drug Targets in Patients Treated with Sorafenib, Carboplatin and Paclitaxel [PDF]

, 2013
Introduction: Sorafenib, a multitarget kinase inhibitor, targets members of the mitogen-activated protein kinase (MAPK) pathway and VEGFR kinases.
John M Kirkwood, Keith T Flaherty, Fengmin Zhao (139710), Kluger Harriet M., Wilson, M, Harriet M Kluger, Jilaveanu Lucia B., Rimm, DL, Lee, Sandra J., Kurt D'Andrea (442217), Rimm David L., Harriet M. Kluger (184091), Kluger, HM, D'Andrea, Kurt, Zhao, F, Kurt D'Andrea, Melissa Wilson (442218), Keith T. Flaherty (226339), Nathanson, KL, Kirkwood, John M., Sandra J. Lee (213144), Lee Sandra J., Fengmin Zhao, D'Andrea, K, Zhao, Fengmin, David L. Rimm (323315), Kirkwood, JM, Flaherty Keith T., Kirkwood John M., Sandra J Lee, Wilson Melissa, Katherine L Nathanson, Flaherty, Keith T., Jilaveanu, LB, John M. Kirkwood (141762), David L Rimm, Rimm, David L., Nathanson Katherine L., Zito, Christopher R., D'Andrea Kurt, Zito, CR, Lucia B Jilaveanu, Zhao Fengmin, Wilson, Melissa, Jilaveanu, Lucia B., Flaherty, KT, Lee, SJ, Katherine L. Nathanson (154077), Melissa Wilson, Smalley, Keiran, Lucia B. Jilaveanu (184077), Kluger, Harriet M., Christopher R. Zito (184074), Zito Christopher R., Christopher R Zito, Nathanson, Katherine L.   +55 more
core   +2 more sources

Uncoupling Type I Interferon Benefits From Inflammatory Toxicity: Transformer‐Prioritized Precision Agonists for Potent and Safer Cancer Immunotherapy

Advanced Science, EarlyView.
A Transformer‐based AI framework, DLINP, screens millions of compounds to identify Co68, a cobalt‐pincer organometallic complex that biases TLR4‐MD2 signaling toward antitumor interferon activation while suppressing inflammatory toxicity through an early TLR4‐SYK‐STAT1 axis.
Xuefei Guo, Yang Zhao, Xianle Rong, Xingyu Chen, Xiao Wang, Tianyi Liu, Yunfei Xie, Yushu Zou, Pingsen Zhao, Qiang Liu, Fuping You   +10 more
wiley   +1 more source