Engineering the paclitaxel biosynthetic pathway in Physcomitrium patens for de novo and stable biosynthesis [PDF]
Nature CommunicationsPaclitaxel is a highly valuable diterpenoid anticancer drug originally extracted from the yew tree. Due to the low efficiency of plant extraction and the high cost of semi-synthesis, efforts have been made to produce paclitaxel through biosynthesis ...
Mengkai Zhao +6 more
doaj +2 more sources
Way to efficient microbial paclitaxel mass production
Synthetic and Systems Biotechnology, 2023 The microbial synthesis of paclitaxel is attractive for its short-cycle, cost-effectiveness, and sustainability. However, low paclitaxel productivity, depleted capacity during subculture and storage, and unclear biosynthesis mechanisms restrain ...
Chenyue Li +4 more
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Developing a Yeast Platform Strain for an Enhanced Taxadiene Biosynthesis by CRISPR/Cas9
Metabolites, 2021 Paclitaxel is an important diterpenoid commonly used as an anticancer drug. Although the paclitaxel biosynthetic pathway has been mostly revealed, some steps remain to be elucidated.
Joseph C. Utomo +4 more
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Genome-Wide Analysis of bZIP Transcription Factors and Expression Patterns in Response to Shading Treatment in Taxus yunnanensis [PDF]
Current Issues in Molecular BiologyBasic leucine zipper (bZIP) transcription factors are widely involved in plant growth, development, environmental adaptation, and secondary metabolism. However, the bZIP gene family in Taxus yunnanensis has not been systematically characterized, and its ...
Jiangtao Fan +8 more
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Prioritization Strategy and Engineering Optimization for Paclitaxel Biosynthesis: From Pathway Analysis to Synthetic Biology [PDF]
BIO Web of ConferencesPaclitaxel, one of the most widely used natural anticancer drugs in clinical treatment, plays a significant role across medicine, public health, and even the economic sphere.
Lin Junkang
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Paclitaxel: new insights into its regulation, biosynthesis and biotechnological production
, 2022 The emergency to obtain effective substances against cancer, and the awareness to protect natural resources make plant biofactories a promising alternative for obtaining plant-derived compounds.
Escrich Montañana, Ainoa
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Biologia Plantarum, 2010 The spatial and temporal expression of dbat and dbtnbt genes involved in the later steps of paclitaxel biosynthesis in relation to baccatin III and paclitaxel accumulation in Taxus baccata L. germinating embryos and seedlings was investigated. The steady-
K. Bruňáková +4 more
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Development of a four-step semi-biosynthesis of the anticancer drug paclitaxel and its analogues [PDF]
, 2015 Paclitaxel (Taxol\uae) is a widely used chemotherapeutic drug with additional medical applications in drug-eluting stents as an anti-restenosis treatment.
Thornburg, Chelsea
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Time‑resolved multi-omic analysis of paclitaxel exposure in human iPSC‑derived sensory neurons unveils mechanisms of chemotherapy‑induced peripheral neuropathy [PDF]
Cell Death and DiseaseThe microtubule-stabilizing drug paclitaxel remains the standard of care for various solid malignancies but frequently leads to chemotherapy-induced peripheral neuropathy (CIPN).
Christian Schinke +17 more
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Metabolic EngineeringIn the quest for innovative cancer therapeutics, paclitaxel remains a cornerstone in clinical oncology. However, its complex biosynthetic pathway, particularly the intricate oxygenation steps, has remained a puzzle in the decades following the ...
Escrich Montañana, Ainoa +6 more
core +5 more sources