Way to efficient microbial paclitaxel mass production [PDF]
Synthetic and Systems Biotechnology, 2023 The microbial synthesis of paclitaxel is attractive for its short-cycle, cost-effectiveness, and sustainability. However, low paclitaxel productivity, depleted capacity during subculture and storage, and unclear biosynthesis mechanisms restrain ...
Chenyue Li +4 more
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Developing a Yeast Platform Strain for an Enhanced Taxadiene Biosynthesis by CRISPR/Cas9 [PDF]
Metabolites, 2021 Paclitaxel is an important diterpenoid commonly used as an anticancer drug. Although the paclitaxel biosynthetic pathway has been mostly revealed, some steps remain to be elucidated.
Joseph C. Utomo +4 more
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Genome-Wide Analysis of bZIP Transcription Factors and Expression Patterns in Response to Shading Treatment in Taxus yunnanensis [PDF]
Current Issues in Molecular BiologyBasic leucine zipper (bZIP) transcription factors are widely involved in plant growth, development, environmental adaptation, and secondary metabolism. However, the bZIP gene family in Taxus yunnanensis has not been systematically characterized, and its ...
Jiangtao Fan +8 more
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Paclitaxel: new insights into its regulation, biosynthesis and biotechnological production [PDF]
, 2022 La emergencia para obtener sustancias efectivas contra el cáncer, y la necesidad de proteger los recursos naturales convierten a las biofactorías vegetales en una alternativa prometedora para obtener compuestos derivados de plantas. En este contexto, la producción biotecnológica del potente agente anticancerígeno paclitaxel podría incrementarse ...
Escrich Montañana, Ainoa
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DEVELOPMENT OF A FOUR-STEP SEMI-BIOSYNTHESIS OF THE ANTICANCER DRUG PACLITAXEL AND ITS ANALOGUES [PDF]
, 2015 Paclitaxel (Taxol\uae) is a widely used chemotherapeutic drug with additional medical applications in drug-eluting stents as an anti-restenosis treatment.
Thornburg, Chelsea
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Expression of two genes of paclitaxel biosynthetic pathway during germination of Taxus baccata zygotic embryos [PDF]
Biologia Plantarum, 2010 The spatial and temporal expression of dbat and dbtnbt genes involved in the later steps of paclitaxel biosynthesis in relation to baccatin III and paclitaxel accumulation in Taxus baccata L. germinating embryos and seedlings was investigated. The steady-
K. Bruňáková +4 more
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Identification and expression analysis of methyl jasmonate responsive ESTs in paclitaxel producing
BMC Genomics, 2012 Background Taxol® (paclitaxel) promotes microtubule assembly and stabilization and therefore is a potent chemotherapeutic agent against wide range of cancers.
Lenka Sangram K +6 more
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Designing an oxidase toolbox for site-directed oxidation of taxanes [PDF]
Nature CommunicationsPaclitaxel is one of the most prominent drugs for cancer therapy, and its synthesis has long been pursued by scientific community. Although the biosynthetic pathway has been gradually unraveled, its synthetic efficiency remains severely constrained by ...
Mingyuan Lai +11 more
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Transcriptome and comparative chloroplast genome analysis of Taxus yunnanensis individuals with high and low paclitaxel yield [PDF]
HeliyonPaclitaxel is a potent anti-cancer drug that is mainly produced through semi-synthesis, which still requires plant materials as precursors. The content of paclitaxel and 10-deacetyl baccatin III (10-DAB) in Taxus yunnanensis has been found to differ from
Dong Wang +7 more
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Genome-wide identification and expression pattern analysis of NAC family in Taxus yunnanensis and the TyuNAC30 role in paclitaxel production [PDF]
BMC GenomicsBackground The NAC transcription factor family represents a large group of plant-specific genes involved in various biological processes, including secondary metabolite biosynthesis, responses to biotic and abiotic stresses, and hormone signaling.
Jiangtao Fan +8 more
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