Whole fungal elicitors boost paclitaxel biosynthesis induction in Corylus avellana cell culture [PDF]
PLoS ONE, 2020 Paclitaxel is an effective natural-source chemotherapeutic agent commonly applied to treat a vast range of cancers. In vitro Corylus avellana culture has been reported as a promising and inexpensive system for paclitaxel production. Fungal elicitors have
Naser Safaie +2 more
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The Paclitaxel Biosynthesis Pathway Unlocked [PDF]
ResearchPaclitaxel, a natural product produced by yew trees, has become an important drug in the fight against cancer. Although more than 4 decades of research have identified numerous enzymes involved in paclitaxel synthesis, our understanding of this pathway’s
Laure Martinelli +2 more
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Application of Priming Strategy for Enhanced Paclitaxel Biosynthesis in Taxus × Media Hairy Root Cultures [PDF]
Cells, 2022 Despite huge progress in biotechnological approaches to paclitaxel production, Taxus spp. in vitro culture productivity still remains a challenge. This could be solved by developing a new strategy engaging mechanisms of the primed defence response joined
Katarzyna Sykłowska-Baranek +4 more
doaj +7 more sources
Modeling of paclitaxel biosynthesis elicitation in Corylus avellana cell culture using adaptive neuro-fuzzy inference system-genetic algorithm (ANFIS-GA) and multiple regression methods [PDF]
PLoS ONE, 2020 Paclitaxel as a microtubule-stabilizing agent is widely used for the treatment of a vast range of cancers. Corylus avellana cell suspension culture (CSC) is a promising strategy for paclitaxel production. Elicitation of paclitaxel biosynthesis pathway is
Naser Safaie +2 more
exaly +5 more sources
Transcriptome and Metabolome Analyses of Taxus chinensis var. mairei Tissues Provide New Insights into the Regulation of Paclitaxel Biosynthesis [PDF]
PlantsTaxus is the natural source of the anticancer drug paclitaxel. Although significant progress has been made in elucidating the biosynthetic pathway of paclitaxel, its tissue-specific accumulation and associated regulatory networks in Taxus remains unclear.
Luyuan Jiang +9 more
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Regulatory microRNAs and phasiRNAs of paclitaxel biosynthesis in Taxus chinensis [PDF]
Frontiers in Plant SciencePaclitaxel (trade name Taxol) is a rare diterpenoid with anticancer activity isolated from Taxus. At present, paclitaxel is mainly produced by the semi-synthetic method using extract of Taxus tissues as raw materials. The studies of regulatory mechanisms
Fang-Fang Fu, Liang-Jiao Xue
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Transcriptome analysis provides insights into light condition effect on paclitaxel biosynthesis in yew saplings [PDF]
BMC Plant Biology, 2022 Background Taxus is a rare gymnosperm plant that is the sole producer of the anticancer drug paclitaxel. The growth and development of Taxus is affected by environmental factors such as light.
Taotao Li +13 more
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Targeted control of supporting pathways in paclitaxel biosynthesis with CRISPR-guided methylation [PDF]
Frontiers in Bioengineering and Biotechnology, 2023 Introduction: Plant cell culture biomanufacturing is rapidly becoming an effective strategy for production of high-value plant natural products, such as therapeutic proteins and small molecules, vaccine adjuvants, and nutraceuticals.
Cassandra Brzycki Newton +2 more
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Mathematical Modeling of Growth and Paclitaxel Biosynthesis in Corylus avellana Cell Culture Responding to Fungal Elicitors Using Multilayer Perceptron-Genetic Algorithm [PDF]
Frontiers in Plant Science, 2020 Paclitaxel is the top-selling anticancer medicine in the world. In vitro culture of Corylus avellana has been made known as a promising and inexpensive strategy for producing paclitaxel. Fungal elicitors have been named as the most efficient strategy for
Mina Salehi +4 more
doaj +2 more sources
A hybrid model based on general regression neural network and fruit fly optimization algorithm for forecasting and optimizing paclitaxel biosynthesis in Corylus avellana cell culture [PDF]
Plant Methods, 2021 Background Paclitaxel is a well-known chemotherapeutic agent widely applied as a therapy for various types of cancers. In vitro culture of Corylus avellana has been named as a promising and low-cost strategy for paclitaxel production.
Mina Salehi +4 more
doaj +2 more sources