Intricate Metabolic Network for Paclitaxel Biosynthesis [PDF]
BioDesign ResearchPaclitaxel is a renowned broad-spectrum anticancer drug. With the establishment of a chromosome-level high-quality reference genome map of Taxus, recent research on paclitaxel biosynthesis has flourished. The oxetane ring is a distinctive chemical moiety
Yuanwei Gou +2 more
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Research Advances in Clinical Applications, Anticancer Mechanism, Total Chemical Synthesis, Semi-Synthesis and Biosynthesis of Paclitaxel [PDF]
Molecules, 2023 Paclitaxel, a natural secondary metabolite isolated and purified from the bark of the Taxus tree, is considered one of the most successful natural anticancer drugs due to its low toxicity, high potency and broad-spectrum anticancer activity.
Fenglan Zhao +2 more
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De Novo characterization of a Cephalotaxus hainanensis transcriptome and genes related to paclitaxel biosynthesis. [PDF]
PLoS ONE, 2014 Cephalotaxus hainanensis, an endangered plant, is known to contain several metabolites with anti-cancer activity. Despite its clinical impact, the alkaloid metabolism of this species has remained largely uncharacterized. The potential of Cephalotaxus for
Fei Qiao +7 more
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The Taxus genome provides insights into paclitaxel biosynthesis [PDF]
Nature Plants, 2021 Abstract The ancient gymnosperm genus Taxus is the exclusive source of the anticancer drug paclitaxel, yet no reference genome sequences are available for comprehensively elucidating the paclitaxel biosynthesis pathway. We have completed a chromosome-level genome of
Jianbin Yan +2 more
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A new 13-lipoxygenase from Taxus media callus is functionally linked to paclitaxel biosynthesis [PDF]
Scientific ReportsThe enzyme 13-Lipoxygenase (13-LOX) plays a pivotal role in the biosynthesis of jasmonates. While Taxus sp. cell suspension cultures have displayed the crucial involvement of Jasmonic acid (JA) in paclitaxel (PTX) biosynthesis activation, 13-LOX had not ...
Abdulsamie Hanano +2 more
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Recent advances in paclitaxel biosynthesis and regulation [PDF]
Journal of Experimental BotanyAbstract Paclitaxel (PTX) is a high value plant natural product derived from Taxus (yew) species. This plant specialized metabolite (PSM) and its derivatives constitute a cornerstone for the treatment of an increasing variety of cancers.
Gary Loake
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Time‑resolved multi-omic analysis of paclitaxel exposure in human iPSC‑derived sensory neurons unveils mechanisms of chemotherapy‑induced peripheral neuropathy [PDF]
Cell Death and DiseaseThe microtubule-stabilizing drug paclitaxel remains the standard of care for various solid malignancies but frequently leads to chemotherapy-induced peripheral neuropathy (CIPN).
Christian Schinke +17 more
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Toward Sustainable Paclitaxel Bioproduction: Plant Biology, Biosynthesis and Platform Engineering [PDF]
PlantsPaclitaxel (Taxol), a taxane diterpenoid from Taxus species, is a clinically important microtubule-stabilizing anticancer agent widely used in chemotherapy.
Meng Zhang, Xing Xing, Hongliang Zhu
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TcMYB73, a salicylic acid-responsive R2R3-MYB transcription factor, positively regulates paclitaxel biosynthesis in Taxus chinensis in direct and indirect ways [PDF]
BMC Plant BiologyBackground Paclitaxel (Taxol) is an invaluable secondary metabolite extracted from Taxus species, wildly utilized in cancer therapeutics. Salicylic acid (SA), an important phytohormone, substantially elevates paclitaxel accumulation in Taxus cell ...
Yifei Ren +5 more
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The Interface amongst Conserved and Specialized Pathways in Non-Paclitaxel and Paclitaxel Accumulating Taxus Cultures [PDF]
Metabolites, 2021 Plant cell cultures derived from Taxus are used to produce valuable metabolites like paclitaxel, a chemotherapeutic drug. Methyl jasmonate elicitation enhances paclitaxel accumulation, but also inhibits culture growth and increases phenylpropanoid ...
Michelle C. McKee +2 more
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