Reconstitution of early paclitaxel biosynthetic network [PDF]
Nature CommunicationsPaclitaxel is an anticancer therapeutic produced by the yew tree. Over the last two decades, a significant bottleneck in the reconstitution of early paclitaxel biosynthesis has been the propensity of heterologously expressed pathway cytochromes P450 ...
Jack Chun-Ting Liu +3 more
doaj +2 more sources
Paclitaxel Biosynthesis: Adenylation and Thiolation Domains of an NRPS TycA PheAT Module Produce Various Arylisoserine CoA Thioesters [PDF]
Biochemistry, 2017 Structure-activity relationship studies show that the phenylisoserinyl moiety of paclitaxel (Taxol) is largely necessary for the effective anticancer activity. Several paclitaxel analogues with a variant isoserinyl side chain have improved pharmaceutical properties versus those of the parent drug.
Ruth Muchiri, Kevin D. Walker
openaire +3 more sources
The biosynthesis and diversity of taxanes: From pathway elucidation to engineering and synthetic biology [PDF]
Plant CommunicationsTaxanes are diterpenoid natural products found in yew trees (Taxus spp.) and include three anticancer agents: paclitaxel, docetaxel, and cabazitaxel.
Jingcheng Shi +5 more
doaj +2 more sources
Identification of two MYB transcription factors that increase paclitaxel biosynthesis in cambial meristematic cells of Taxus baccata [PDF]
, 2018 Paclitaxel is an anticancer natural product with several biomedical applications produced by Taxus species, with a demand exceeding its supply. We have developed cambial meristematic cells (CMCs) from Taxus cuspidata as high yield source of paclitaxel. The biosynthesis of paclitaxel is predominantly under transcriptional control.
Ochoa-Villarreal, Marisol
openaire +3 more sources
Deep sequencing reveals transcriptome re-programming of Taxus × media cells to the elicitation with methyl jasmonate. [PDF]
PLoS ONE, 2013 Plant cell culture represents an alternative source for producing high-value secondary metabolites including paclitaxel (Taxol®), which is mainly produced in Taxus and has been widely used in cancer chemotherapy.
Guiling Sun +8 more
doaj +1 more source
Fungal Cell Wall and Methyl-β-Cyclodextrin Synergistically Enhance Paclitaxel Biosynthesis and Secretion in Corylus avellana Cell Suspension Culture. [PDF]
Sci Rep, 2020 AbstractPaclitaxel is the top-selling chemotherapeutic drug used for the treatment of lung, ovarian and breast cancer as well as Kaposi’s sarcoma. Cell suspension culture (CSC) of Corylus avellana has been addressed as a promising alternative for producing paclitaxel.
Farhadi S +4 more
europepmc +4 more sources
Draft Genome Sequence of Grammothele lineata SDL-CO-2015-1, a Jute Endophyte with a Potential for Paclitaxel Biosynthesis. [PDF]
Genome Announc, 2017 ABSTRACT Grammothele lineata strain SDL-CO-2015-1, a basidiomycete fungus, was identified as an endophyte from a jute species, Corchorus olitorius var. 2015, and found to produce paclitaxel, a diterpenic polyoxygenated pseudoalkaloid with antitumor activity.
Das A +7 more
europepmc +3 more sources
PLoS ONE, 2023 Although bioproduction of Paclitaxel by endophytic fungi is highly considered as an alternative promising source, but its yield is usually very low in comparison with other taxoids.
Narjes Mohammadi Ballakuti +1 more
doaj +2 more sources
Endophytes as alternative paclitaxel sources : chemistry and genetics of Taxomyces andreanae and the endophytic flora of Wollemia nobilis [PDF]
, 2010 Whether suffering a pathogenic attack, basking in symbiotic comfort, or seemingly symptomless, plants constantly participate in molecular interplay with various classes of microbial organisms.
Staniek, Agata Agnieszka +5 more
core +1 more source