Results 31 to 40 of about 291,802 (171)

Identification of two MYB transcription factors that increase paclitaxel biosynthesis in cambial meristematic cells of Taxus baccata [PDF]

, 2018
Paclitaxel is an anticancer natural product with several biomedical applications produced by Taxus species, with a demand exceeding its supply. We have developed cambial meristematic cells (CMCs) from Taxus cuspidata as high yield source of paclitaxel.
Ochoa-Villarreal, Marisol
core   +2 more sources

Reconstitution of early paclitaxel biosynthetic network

Nature Communications
Paclitaxel is an anticancer therapeutic produced by the yew tree. Over the last two decades, a significant bottleneck in the reconstitution of early paclitaxel biosynthesis has been the propensity of heterologously expressed pathway cytochromes P450 ...
Jack Chun-Ting Liu, Ricardo De La Peña, Christian Tocol, Elizabeth S. Sattely   +3 more
doaj   +2 more sources

A minimal transcription factor network is sufficient to drive paclitaxel biosynthesis. [PDF]

Sci Adv
The supply of the anticancer drug paclitaxel is limited by its low natural abundance and complex chemical structure. We previously reported the development of a cultured Taxus cambial meristematic cell (CMC) system, where methyl jasmonate enhances paclitaxel production.
Pan Q, Ochoa-Villarreal M, Howat S, Amir R, Yan Z, French CE, Loake GJ, Cui B.   +7 more
europepmc   +3 more sources

Plant Metabolites Screening Identifies 7-epi-10-Deacetyltaxol Inhibiting Cell Division by Interfering With the Cell Cycle and Microtubule Organization. [PDF]

Adv Sci (Weinh)
In this study, an efficient screening system is developed for plant metabolites to find a compound, 7‐epi‐10‐deacetyltaxol, inhibits tissue elongation. It suppresses plant growth through brassinosteroid and microtubule pathways. It is later applied to animal cells and human tumor organoids, resulting in similar cell division suppression. These findings
Zhang YJ, Bai YX, Tian GG, Zhang B, Lu DY, Yao QP, Tian WH, Wei XN, Yang JT, Xiong ZY, Lu Y, Jiang YT, Cai CH, Lu YM, Jia XQ, Jing LL, Yang BJ, Qi YX, Han XX, Wu J, Lin WH.   +20 more
europepmc   +2 more sources

Deep sequencing reveals transcriptome re-programming of Taxus × media cells to the elicitation with methyl jasmonate. [PDF]

PLoS ONE, 2013
Plant cell culture represents an alternative source for producing high-value secondary metabolites including paclitaxel (Taxol®), which is mainly produced in Taxus and has been widely used in cancer chemotherapy.
Guiling Sun, Yanfang Yang, Fuliang Xie, Jian-Fan Wen, Jianqiang Wu, Iain W Wilson, Qi Tang, Hongwei Liu, Deyou Qiu   +8 more
doaj   +1 more source

Developed network between taxoid and phenylpropanoid pathways in Cryptosporiopsis tarraconensis, taxan-producing endophytic fungus by Debiased Sparse Partial Correlation (DSPC) algorithm

PLoS ONE, 2023
Although bioproduction of Paclitaxel by endophytic fungi is highly considered as an alternative promising source, but its yield is usually very low in comparison with other taxoids.
Narjes Mohammadi Ballakuti, Faezeh Ghanati   +1 more
doaj   +2 more sources

Safety and efficacy of sirolimus- and paclitaxel-eluting coronary stents. [PDF]

, 2007
BACKGROUND: The safety of drug-eluting stents has been called into question by recent reports of increased stent thrombosis, myocardial infarction, and death.
Kirtane, Ajay J, Schampaert, Erick, Dawkins, Keith D, Morice, Marie-Claude, Pocock, Stuart J, Fahy, Martin, Stone, Gregg W, Colombo, Antonio, Moses, Jeffrey W, Cutlip, Donald E, Ellis, Stephen G, Grube, Eberhard, Leon, Martin B, Mehran, Roxana, Schofer, Joachim   +14 more
core   +1 more source

Paclitaxel: biosynthesis, production and future prospects

New Biotechnology, 2014
Plants are capable of producing a wide variety of secondary metabolites which have a diverse range of functions that can be exploited for medicinal purposes; for example, paclitaxel is a major anti-cancer drug found in the bark of Taxus spp. There are however supply issues as the compound is only found at low concentrations (0.05%) within the plant ...
Susan, Howat, Bora, Park, Il Suk, Oh, Young-Woo, Jin, Eun-Kyong, Lee, Gary J, Loake   +5 more
openaire   +2 more sources

Draft Genome Sequence of Grammothele lineata SDL-CO-2015-1, a Jute Endophyte with a Potential for Paclitaxel Biosynthesis. [PDF]

Genome Announc, 2017
ABSTRACT Grammothele lineata strain SDL-CO-2015-1, a basidiomycete fungus, was identified as an endophyte from a jute species, Corchorus olitorius var. 2015, and found to produce paclitaxel, a diterpenic polyoxygenated pseudoalkaloid with antitumor activity.
Das A, Ahmed O, Baten AKMA, Bushra S, Islam MT, Ferdous AS, Islam MR, Khan H.   +7 more
europepmc   +3 more sources

MDA-MB-231-MATRIGEL-PACLITAXEL

, 2023
TNBC cells of the MDA-MB-231 cell line (transfected with  GFP) were cultured in Matrigel scaffold for 15 days.  Paclitaxel was administered on day 5.
Nikolaos Dimitriou (10179131)
core   +1 more source