Results 61 to 70 of about 12,321 (161)

Engineering Extracellular Vesicles: Strategies for Functional Modification and Clinical Translation

iNew Medicine, EarlyView.
The engineering modification strategies of extracellular vesicles (EVs). This figure presents the four core technical systems for the engineering modification of EVs, including direct modification strategies (physical and chemical methods), biological engineering methods, and hybrid and bionic strategies.
Zhouming Cheng, Wenhui Zhao, Min Wang, Xianwen Wang   +3 more
wiley   +1 more source

Reversing brain aging: Targeting energy metabolism in endogenous neural stem cells

Interdisciplinary Medicine, EarlyView.
Mechanism of endogenous neural stem cells (eNSCs) energy metabolism disorder leading to brain aging and targeted eNSCs intervention strategies (By biorender). The disorder of energy metabolism of eNSCs can lead to their resting and aging, and eventually lead to brain aging.
Chong Chen, Jiayi Wang, Jimin Yu, Yiran Zhou, Lihai Liu, Jing Liu, Liang Wang   +6 more
wiley   +1 more source

A cellulase-supported two-phase in situ system for enhanced biosynthesis of paclitaxel in Taxus × media hairy roots [PDF]

Acta Physiologiae Plantarum, 2018
The effectiveness of two liquid-phase culture systems, in situ supported with perfluorodecalin (PFD), and elicited with methyl jasmonate (100 µM) and sodium nitroprusside (10 µM) (spiked with l-phenylalanine (100 µM) and sucrose (30 g/l) feeding), and additionally combined with cellulolytic enzyme application (Cellulase or Viscozyme® L at doses 0.01 ...
K. Sykłowska-Baranek, K. Szala, M. Pilarek, R. Orzechowski, A. Pietrosiuk   +4 more
openaire   +1 more source

Mitochondria‐targeted nanomedicine for cancer therapy: Targeting strategies, therapeutic mechanisms, and translational challenges

Interdisciplinary Medicine, EarlyView.
This review highlights recent advances in mitochondria‐targeted nanomedicine for cancer therapy. It summarizes key targeting strategies and delineates four principal therapeutic mechanisms: oxidative stress–induced mitochondrial dysfunction, disruption of energy metabolism, direct mitochondrial damage, and induction of immunogenic cell death.
Linfeng Xiao, Xiaowei Chang, Jun Zhang, Yinshan Hong, Wenhui Cao, Zhewu Zhao, Yu‐E. Wang, Yanling Yang   +7 more
wiley   +1 more source

Bioactive Natural Products in Cardiovascular Disease: Focus on Thrombotic Events

Phytotherapy Research, EarlyView.
An overview of the role of natural products (NP) in cardiovascular disease prevention, highlighting key mechanisms of action: including antiplatelet, antithrombotic, anti‐inflammatory, and antioxidant effects. Additionally, it illustrates the integration of diet–drug interactions, nutritional epigenetics, and the role of artificial intelligence in ...
Maria Nektaria Magkoulia, Despoina Pantazi   +1 more
wiley   +1 more source

Taxomyces andreanae: A Presumed Paclitaxel Producer Demystified? [PDF]

, 2009
The 1990s brought an abundance of reports on paclitaxel-producing endophytes, initially heralded as a discovery having tremendous implications for cancer therapy.
Woerdenbag, Herman J.; id_orcid, Woerdenbag, Herman J., Staniek, Agata, Kayser, Oliver   +3 more
core   +1 more source

Integrative multi-omics reveals shading effects on polysaccharide and secondary metabolism in Taxus media × T. yunnanensis

Environmental and Experimental Botany
Light is a critical environmental factor that regulates plant development and secondary metabolism, but its molecular influence on paclitaxel biosynthesis in Taxus remains unclear.
Jiangtao Fan, Yingxue Ma, Mengke Dou, Jiangtao Fu, Yu Sui, Yujia Liu, Yingying He, Pengpeng Gong, Wenjing Miu, Hongwei Chen, Yong Wang, Gang Wang, Xiong Huang   +12 more
doaj   +1 more source

Cell‐Specific Expression and Cellular Compartmental Regulation in Camptothecin Biosynthesis

Plant Biotechnology Journal, EarlyView.
ABSTRACT Plant secondary metabolites such as monoterpenoid indole alkaloids (MIAs) show tightly regulated biosynthesis and accumulation in specific organelles of distinct cell types. However, the cell‐specific expression patterns of anticancer MIA camptothecin biosynthetic genes in Ophiorrhiza pumila and the regulatory mechanisms of camptothecin ...
Xiaolong Hao, Yinkai Yang, Tiantian Chen, Xiaoxuan Fan, Yiqing Peng, Qingyan Ruan, Qin Zhou, Fanghao Liu, Jiayi He, Yongpeng Li, Yue Feng, Jiyan Qi, Guoyin Kai   +12 more
wiley   +1 more source

GhTTLL12 Coordinates With Transcriptional Regulators GhMML3 and GhMYB86 to Orchestrate Cotton Fibre Development Through Modulating Microtubule Dynamics

Plant Biotechnology Journal, EarlyView.
ABSTRACT Microtubules (MTs) are crucial for cell division, growth, development and morphogenesis in plants. Cotton fibres are single‐celled trichomes that originate from the epidermal cells of the ovule, making them an excellent model for studying plant cell differentiation and rapid elongation.
Xiaowei Ma, Xubinmiao Huang, Jinfang Li, Ting Zhao, Zhenfeng Ling, Shengcai Huang, Zesheng Rui, Yue Shi, Yulin Xing, Lei Sun, Mengting Wang, Haoxi Song, Rui Chen, Zequan Chen, Lei Shao, Nangan Sun, Junduo Wang, Juyun Zheng, Lei Fang   +18 more
wiley   +1 more source

Chemical Inhibitors Suggest Endophytic Fungal Paclitaxel Is Derived from Both Mevalonate and Non-mevalonate-like Pathways [PDF]

, 2016
Taxus trees possess fungal endophytes reported to produce paclitaxel. Inhibitors that block early steps in plant paclitaxel biosynthesis were applied to a paclitaxel-producing fungus to determine whether these steps are shared.
Rong Tsao (52985), Manish N. Raizada (218573), Sameh S. M. Soliman (2133694)   +2 more
core   +1 more source