Results 141 to 150 of about 291,802 (171)

Anticancer Secondary Metabolites Produced by Fungi: Potential and Representative Compounds. [PDF]

Int J Mol Sci
García-Estrada C, Barreiro C, Martín JF.   +2 more
europepmc   +1 more source

Plant-Microbiome Interactions in Medicinal Plants: A Synergistic Partnership for Biomass Production and Secondary Metabolite Accumulation. [PDF]

Microorganisms
Wang E, Zhang Y, Yue R, Wang Y, Ma X, Zhang G, Jin L.   +6 more
europepmc   +1 more source

Comparative Transcriptomic Analysis Provides Insights into PSK-α-Mediated Regulation of Diosgenin Biosynthesis in <i>Trigonella foenum-graecum</i>. [PDF]

Molecules
Xu C, Zhan H, Mehraliyeva M, Liu H, Zheng M, Li C, Zhang Y.   +6 more
europepmc   +1 more source

Synthetic Biology Identifies the Minimal Gene Set Required for Paclitaxel Biosynthesis in a Plant Chassis [PDF]

Molecular Plant, 2023
The diterpenoid paclitaxel (Taxol) is a chemotherapy medication widely used as a first-line treatment against several types of solid cancers. The supply of paclitaxel from natural sources is limited. However, missing knowledge about the genes involved in
John Molloy, Alisdair R Fernie, Mathias Christmann   +2 more
exaly   +8 more sources

Post-Genomic Illumination of Paclitaxel Biosynthesis

Nature Plants
Paclitaxel rapidly became one of the most effective anticancer drugs. However, the production of paclitaxel is hindered by substantial challenges, particularly considering the significant quantities of drug required and the inherently low concentration ...
Alisdair R Fernie, Youjun Zhang
exaly   +5 more sources

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Biosynthesis of paclitaxel using synthetic biology

Phytochemistry Reviews, 2021
Paclitaxel is a tricyclic diterpenoid first isolated from the bark of Taxus brevifolia. It is notably one of the most effective natural anticancer drugs discovered so far, and has been widely used in the treatment of breast, ovarian, lung cancer, as well as other diseases.
Yuru Tong, Yunfeng F Luo, Wei Gao
openaire   +1 more source

Expression Profiling of Genes Involved in Paclitaxel Biosynthesis for Targeted Metabolic Engineering

Metabolic Engineering, 2006
Taxus plant suspension cell cultures provide a sustainable source of paclitaxel (Taxol) for the treatment of many cancers. To develop an optimal bioprocess for paclitaxel supply, taxane biosynthetic pathway regulation must be better understood. Here we examine the expression profile of paclitaxel biosynthetic pathway genes by RNA gel blot analysis and ...
Susan C Roberts, Elsbeth Walker
exaly   +4 more sources

Cutaneous Photosensitivity Induced by Paclitaxel and Trastuzumab Therapy Associated With Aberrations in the Biosynthesis of Porphyrins

Journal of Dermatological Treatment, 2005
Paclitaxel and trastuzumab are new treatments for patients with metastatic breast cancer.We describe here a 40-year-old female patient with metastatic breast cancer who developed a photosensitive rash 1 month after initiation of paclitaxel and trastuzumab therapy.
Arnon Cohen, Nili Schoenfeld, D B Geffen
exaly   +3 more sources

The History of Studies on Oxetane Ring Formation in Paclitaxel Biosynthesis

ChemBioChem
AbstractThere is no doubt that breakthroughs in the enzyme‐mediated formation of the oxetane ring in paclitaxel biosynthesis constitute significant milestones in the biosynthesis of complex natural products. In this review, we summarize the understanding of the biosynthesis of the oxetane ring of paclitaxel from different viewpoints.
Jungui Dai, Changkang Li
exaly   +3 more sources

Metabolic Engineering of Taxadiene Biosynthesis in Yeast as a First Step Towards Taxol (Paclitaxel) Production

Metabolic Engineering, 2008
Metabolic engineering in microbes could be used to produce large amounts of valuable metabolites that are difficult to extract from their natural sources and too expensive or complex to produce by chemical synthesis. As a step towards the production of Taxol in the yeast Saccharomyces cerevisiae, we introduced heterologous genes encoding biosynthetic ...
Stefan Jennewein, Benedikt Engels, Pia Dahm   +2 more
exaly   +3 more sources