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Synthetic biology identifies the minimal gene set required for paclitaxel biosynthesis in a plant chassis [PDF]
Molecular Plant, 2023 The diterpenoid paclitaxel (Taxol) is a chemotherapy medication widely used as a first-line treatment against several types of solid cancers. The supply of paclitaxel from natural sources is limited. However, missing knowledge about the genes involved in several specific metabolic steps of paclitaxel biosynthesis has rendered it difficult to engineer ...
Alisdair Fernie +2 more
exaly +10 more sources
Post-genomic illumination of paclitaxel biosynthesis [PDF]
Nature PlantsPaclitaxel rapidly became one of the most effective anticancer drugs. However, the production of paclitaxel is hindered by substantial challenges, particularly considering the significant quantities of drug required and the inherently low concentration of paclitaxel and its intermediates in plants.
Alisdair Fernie +2 more
exaly +5 more sources
A novel step towards the heterologous biosynthesis of paclitaxel: Characterization of T1βOH taxane hydroxylase [PDF]
Metabolic EngineeringIn the quest for innovative cancer therapeutics, paclitaxel remains a cornerstone in clinical oncology. However, its complex biosynthetic pathway, particularly the intricate oxygenation steps, has remained a puzzle in the decades following the characterization of the last taxane hydroxylase.
Moyano Elisabeth +2 more
exaly +12 more sources
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Biosynthesis of paclitaxel using synthetic biology
Phytochemistry Reviews, 2021Paclitaxel is a tricyclic diterpenoid first isolated from the bark of Taxus brevifolia. It is notably one of the most effective natural anticancer drugs discovered so far, and has been widely used in the treatment of breast, ovarian, lung cancer, as well as other diseases.
Wei Gao, Yuru Tong, Wei Gao
exaly +2 more sources
Expression profiling of genes involved in paclitaxel biosynthesis for targeted metabolic engineering
Metabolic Engineering, 2006Taxus plant suspension cell cultures provide a sustainable source of paclitaxel (Taxol) for the treatment of many cancers. To develop an optimal bioprocess for paclitaxel supply, taxane biosynthetic pathway regulation must be better understood. Here we examine the expression profile of paclitaxel biosynthetic pathway genes by RNA gel blot analysis and ...
Susan Roberts, Elsbeth Walker
exaly +4 more sources
Journal of Dermatological Treatment, 2005 Paclitaxel and trastuzumab are new treatments for patients with metastatic breast cancer.We describe here a 40-year-old female patient with metastatic breast cancer who developed a photosensitive rash 1 month after initiation of paclitaxel and trastuzumab therapy.
N Schoenfeld, R Mamet, W Mermershtain
exaly +3 more sources
The History of Studies on Oxetane Ring Formation in Paclitaxel Biosynthesis
ChemBioChemAbstractThere is no doubt that breakthroughs in the enzyme‐mediated formation of the oxetane ring in paclitaxel biosynthesis constitute significant milestones in the biosynthesis of complex natural products. In this review, we summarize the understanding of the biosynthesis of the oxetane ring of paclitaxel from different viewpoints.
Jungui Dai
exaly +3 more sources
TcJAMYC5 positively regulates paclitaxel biosynthesis in Taxus chinensis var. Mairei
Plant Molecular BiologyPaclitaxel is an important natural anticancer drug. Its biosynthesis is very complex and 18 enzymes likely involved have been characterized. However, the regulatory mechanism of these enzyme genes still remains to be elucidated. Here we identified a novel transcription factor in the MYC family of Taxus chinensis TcJAMYC5 function in paclitaxel ...
Xiaoying Cao +2 more
exaly +3 more sources
Applied Microbiology and Biotechnology, 2023
Paclitaxel (Taxol®) is the most popular anticancer diterpenoid predominantly present in Taxus. The core skeleton of paclitaxel is highly modified, but researches on the cytochrome P450s involved in post-modification process remain exceedingly limited. Herein, the taxane-10β-hydroxylase (T10βH) from Taxus cuspidata, which is the third post-modification ...
Mei-Fang Zhang +4 more
openaire +2 more sources
Paclitaxel (Taxol®) is the most popular anticancer diterpenoid predominantly present in Taxus. The core skeleton of paclitaxel is highly modified, but researches on the cytochrome P450s involved in post-modification process remain exceedingly limited. Herein, the taxane-10β-hydroxylase (T10βH) from Taxus cuspidata, which is the third post-modification ...
Mei-Fang Zhang +4 more
openaire +2 more sources
Metabolic Engineering, 2008
Metabolic engineering in microbes could be used to produce large amounts of valuable metabolites that are difficult to extract from their natural sources and too expensive or complex to produce by chemical synthesis. As a step towards the production of Taxol in the yeast Saccharomyces cerevisiae, we introduced heterologous genes encoding biosynthetic ...
Stefan Jennewein, Benedikt Engels
exaly +3 more sources
Metabolic engineering in microbes could be used to produce large amounts of valuable metabolites that are difficult to extract from their natural sources and too expensive or complex to produce by chemical synthesis. As a step towards the production of Taxol in the yeast Saccharomyces cerevisiae, we introduced heterologous genes encoding biosynthetic ...
Stefan Jennewein, Benedikt Engels
exaly +3 more sources