Results 151 to 160 of about 291,802 (171)
Some of the next articles are maybe not open access.
Applied Microbiology and Biotechnology, 2023
Paclitaxel (Taxol®) is the most popular anticancer diterpenoid predominantly present in Taxus. The core skeleton of paclitaxel is highly modified, but researches on the cytochrome P450s involved in post-modification process remain exceedingly limited. Herein, the taxane-10β-hydroxylase (T10βH) from Taxus cuspidata, which is the third post-modification ...
Mei-Fang Zhang +4 more
openaire +2 more sources
Paclitaxel (Taxol®) is the most popular anticancer diterpenoid predominantly present in Taxus. The core skeleton of paclitaxel is highly modified, but researches on the cytochrome P450s involved in post-modification process remain exceedingly limited. Herein, the taxane-10β-hydroxylase (T10βH) from Taxus cuspidata, which is the third post-modification ...
Mei-Fang Zhang +4 more
openaire +2 more sources
TcJAMYC5 Positively Regulates Paclitaxel Biosynthesis in Taxus chinensis var. Mairei
Plant Molecular BiologyPaclitaxel is an important natural anticancer drug. Its biosynthesis is very complex and 18 enzymes likely involved have been characterized. However, the regulatory mechanism of these enzyme genes still remains to be elucidated. Here we identified a novel transcription factor in the MYC family of Taxus chinensis TcJAMYC5 function in paclitaxel ...
Xiaoying Cao, Ludan Li, Wen Wan
exaly +3 more sources
A Cytochrome P450 Enzyme Catalyses Oxetane Ring Formation in Paclitaxel Biosynthesis
Angewandte Chemie - International EditionAbstractOxetane synthase (TmCYP1), a novel cytochrome P450 enzyme from Taxus×media cell cultures, has been functionally characterized to efficiently catalyse the formation of the oxetane ring in tetracyclic taxoids. Transient expression of TmCYP1 in Nicotiana benthamiana using 2α,5α,7β,9α,10β,13α‐hexaacetoxytaxa‐4(20),11(12)‐diene (1) as a substrate ...
Kebo Xie, Jungui Dai, Ridao Chen
exaly +3 more sources
A Novel Step Towards the Heterologous Biosynthesis of Paclitaxel: Characterization of T1βOH Taxane Hydroxylase [PDF]
Metabolic EngineeringIn the quest for innovative cancer therapeutics, paclitaxel remains a cornerstone in clinical oncology. However, its complex biosynthetic pathway, particularly the intricate oxygenation steps, has remained a puzzle in the decades following the ...
Elisabeth Moyano +2 more
exaly +2 more sources
Recent advances and perspectives in biosynthesis of paclitaxel: key enzymes and intermediates
International Journal of Biological MacromoleculesPlants represent a natural source of diverse secondary metabolites with anticancer activities. Among these metabolites, paclitaxel (Taxol®), a well-known chemotherapeutic agent isolated from Taxus spp., is widely used in the treatment of multiple types of cancers.
Qingqing, Chen +5 more
openaire +2 more sources
Biochemistry, 2017
Structure-activity relationship studies show that the phenylisoserinyl moiety of paclitaxel (Taxol) is largely necessary for the effective anticancer activity. Several paclitaxel analogues with a variant isoserinyl side chain have improved pharmaceutical properties versus those of the parent drug.
Ruth Muchiri, Kevin D. Walker
openaire +2 more sources
Structure-activity relationship studies show that the phenylisoserinyl moiety of paclitaxel (Taxol) is largely necessary for the effective anticancer activity. Several paclitaxel analogues with a variant isoserinyl side chain have improved pharmaceutical properties versus those of the parent drug.
Ruth Muchiri, Kevin D. Walker
openaire +2 more sources
[Advances in paclitaxel biosynthesis and transcriptional regulation mechanisms].
Sheng wu gong cheng xue bao = Chinese journal of biotechnologyPaclitaxel, a rare diterpene extracted from the bark of Chinese yew (Taxus chinensis), is renowned for its anti-cancer activity and serves as a primary drug for treating cancers. Due to the exceptionally low content of paclitaxel in the bark, a semi-synthetic method that depletes Chinese yew resources is used in the production of paclitaxel, which ...
Fanshu, Sun +6 more
openaire +1 more source
Biosynthesis of Paclitaxel Using Synthetic Biology
Phytochemistry Reviews, 2022Wei Gao, Yuru Tong, Wei Gao
exaly