Results 151 to 160 of about 12,321 (161)

A Cytochrome P450 Enzyme Catalyses Oxetane Ring Formation in Paclitaxel Biosynthesis

Angewandte Chemie - International Edition
AbstractOxetane synthase (TmCYP1), a novel cytochrome P450 enzyme from Taxus×media cell cultures, has been functionally characterized to efficiently catalyse the formation of the oxetane ring in tetracyclic taxoids. Transient expression of TmCYP1 in Nicotiana benthamiana using 2α,5α,7β,9α,10β,13α‐hexaacetoxytaxa‐4(20),11(12)‐diene (1) as a substrate ...
Jungui Dai
exaly   +3 more sources

Recent advances and perspectives in biosynthesis of paclitaxel: key enzymes and intermediates

International Journal of Biological Macromolecules
Plants represent a natural source of diverse secondary metabolites with anticancer activities. Among these metabolites, paclitaxel (Taxol®), a well-known chemotherapeutic agent isolated from Taxus spp., is widely used in the treatment of multiple types of cancers.
Xin Ge, Qi Xin, Xiao Men
exaly   +3 more sources

Identification of missing CYP450 enzymes involved in paclitaxel biosynthesis and heterologous reconstitution of baccatin III

Chinese Journal of Natural Medicines
Pan Liao
exaly   +3 more sources

[Advances in paclitaxel biosynthesis and transcriptional regulation mechanisms].

Sheng wu gong cheng xue bao = Chinese journal of biotechnology
Paclitaxel, a rare diterpene extracted from the bark of Chinese yew (Taxus chinensis), is renowned for its anti-cancer activity and serves as a primary drug for treating cancers. Due to the exceptionally low content of paclitaxel in the bark, a semi-synthetic method that depletes Chinese yew resources is used in the production of paclitaxel, which ...
Fanshu, Sun, Shuyang, Dang, Dongran, Zheng, He, Zhang, Yu, Wang, Yuhua, Li, Hao, Wu   +6 more
openaire   +1 more source

Identification and characterization of key regulators of Paclitaxel Biosynthesis in Taxus cuspidata

2016
Numerous drugs in the current pharmacopoeia originate from plant sources. Plant cell culture represents an alternative source for producing high-value secondary metabolites including paclitaxel. Paclitaxel is mainly derived from the plant genus Taxus and has been widely used in cancer chemotherapy.
openaire   +1 more source

Influence of mild γ-irradiation on growth and paclitaxel biosynthesis in hazel (Corylus avellana L.) in vitro culture

Plant Cell, Tissue and Organ Culture (PCTOC), 2023
Raziyeh Adabi, Ayatollah Rezaei
openaire   +1 more source

Tissue‐specific study across the stem of Taxus media identifies a phloem‐specific TmMYB3 involved in the transcriptional regulation of paclitaxel biosynthesis

Plant Journal, 2020
Chenjia Shen
exaly  

A new era for paclitaxel biosynthesis is coming

Molecular Plant
Xiaonan Liu, Xiaoxi Zhu, Jian Cheng, Huifeng Jiang   +3 more
openaire   +2 more sources

Emerging Technologies Empowering the Biosynthesis of Paclitaxel

Synthetic Biology and Engineering
Liu Xiaonan, Zhang Yuanyuan, Li Jing, Jiang Huifeng   +3 more
openaire   +1 more source

Identification of transcription factors controlling the expression of paclitaxel biosynthesis genes in cambial meristematic cells of Taxus cuspidata

2015
Paclitaxel is an antitumor diterpene from Taxus spp. that binds tubulin, stabilizes microtubules and induces apoptosis in dividing human cells. It was originally isolated from the bark of Taxus brevifolia and approved for clinic uses by the FDA in 1992. Because of its excellent activity in treatment of various cancers, a significant supply shortage has
openaire   +1 more source