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Identification and characterization of key regulators of Paclitaxel Biosynthesis in Taxus cuspidata
2016Numerous drugs in the current pharmacopoeia originate from plant sources. Plant cell culture represents an alternative source for producing high-value secondary metabolites including paclitaxel. Paclitaxel is mainly derived from the plant genus Taxus and has been widely used in cancer chemotherapy.
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A new era for paclitaxel biosynthesis is coming
Molecular PlantXiaonan Liu +3 more
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Plant Cell, Tissue and Organ Culture (PCTOC), 2023
Raziyeh Adabi, Ayatollah Rezaei
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Raziyeh Adabi, Ayatollah Rezaei
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Emerging Technologies Empowering the Biosynthesis of Paclitaxel
Synthetic Biology and EngineeringLiu Xiaonan +3 more
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2015
Paclitaxel is an antitumor diterpene from Taxus spp. that binds tubulin, stabilizes microtubules and induces apoptosis in dividing human cells. It was originally isolated from the bark of Taxus brevifolia and approved for clinic uses by the FDA in 1992. Because of its excellent activity in treatment of various cancers, a significant supply shortage has
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Paclitaxel is an antitumor diterpene from Taxus spp. that binds tubulin, stabilizes microtubules and induces apoptosis in dividing human cells. It was originally isolated from the bark of Taxus brevifolia and approved for clinic uses by the FDA in 1992. Because of its excellent activity in treatment of various cancers, a significant supply shortage has
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