Results 41 to 50 of about 34,391 (244)

Antigen‐Detected NMR for Minimal Epitope Engineering and Structure‐Guided Selection of a NaV1.7‐Selective Nanobody

Advanced Science, EarlyView.
A minimal extracellular epitope from voltage‐gated sodium channel NaV1.7 was engineered into an isotope‐labelled antigen for antigen‐detected nuclear magnetic resonance (NMR). Together with AlphaFold2 (AF2), this enabled structure‐guided selection of R4C8, a human NaV1.7‐selective nanobody that labels fixed NaV1.7‐expressing cells and produces staining
Junyu Liu, Wanlin Chen, Ben Cristofori‐Armstrong, Theo Crawford, Kai‐En Chen, Peng Xie, Rainbow Wing Bo Chan, Yifei Zhu, Mimi Golder, Anneka Pereira Schmidt, Jennifer D. Naughton, Nicholas D. Condon, Åsa Andersson, Farhad Dehkhoda, Kirsten L. McMahon, Tabea Klasfauseweh, Ashvriya Thapa, Hue Tran, Poanna Tran, Sina Jami, Lotten Ragnarsson, Sebastian G. B. Furness, Jennifer R. Deuis, Brett M. Collins, Wai‐Hong Tham, Indira Prasadam, Irina Vetter, Mehdi Mobli   +27 more
wiley   +1 more source

Paeoniflorin inhibits the growth of bladder carcinoma via deactivation of STAT3

Acta Pharmaceutica, 2018
Bladder cancer (BCa) is one of the most common urinary cancers. The present study aims to investigate whether Paeoniflorin (Pae) can exert inhibitory effects on BCa.
Yang Jianhui, Ren Yu, Lou Zhong-Guan, Wan Xue, Weng Guo-Bin, Cen Dong   +5 more
doaj   +1 more source

Carboxymethylcellulose (CMC) as a model compound of cellulose fibers and polyamideamine epichlorohydrin (PAE)–CMC interactions as a model of PAE–fibers interactions of PAE‐based wet strength papers

, 2015
International audienceCarboxymethylcellulose (CMC) is a cellulose derivative obtained by the carboxymethylation of some hydroxyl groups in the cellulose macromolecules.
Eder J. Siqueira, Siqueira, Eder, Belgacem, Mohamed, Marie‐Christine B. Salon, Mohamed N. Belgacem, Evelyne Mauret, Mauret, Evelyne, Salon, Marie‐christine   +7 more
core   +1 more source

PTBP1‐Mediated Alternative Splicing of DNAJB6 Promotes Everolimus Resistance in Clear Cell Renal Cell Carcinoma via EIF4B/PKIB/AKT/mTOR Positive Feedback Loop

Advanced Science, EarlyView.
PTBP1‐mediated alternative splicing drives a pathogenic switch to the DNAJB6b isoform in everolimus‐resistant clear cell renal cell carcinoma. This splicing event programs a positive feedback loop including EIF4B/PKIB/AKT/mTOR, promoting aggressive therapy resistance.
Xiu‐wu Pan, Hong‐feng Zheng, Mu‐chen Li, Jia‐lin Zhou, Hang‐biao Zhang, Dong‐hao Lyu, Yi‐fan Tang, Tian‐yue Yang, Yi‐fan Liu, Zi‐chang Liu, Wen‐jie Ma, Yuan‐bo Zong, Jian‐gui Liu, Zi‐xuan Gong, Hao Zhang, Ke‐qin Dong, Wang Zhou, Jian‐qin Ye, Xin‐gang Cui   +18 more
wiley   +1 more source

Exhibition review: Fatu Feu'u, "Pae Pae"

, 2014
Exhibition review: Fatu Feu'u, "Pae Pae", Warwick Henderson Gallery, 24 June - 12 July 2014, published in "Art New Zealand", No. 151, Spring 2014, p. 44.
Hanfling, Edward
core   +1 more source

Anticoccidial effects of the Plantago asiatica extract on experimental Eimeria tenella infection

Laboratory Animal Research, 2016
Anticoccidial effects of the Plantago asiatica extract (PAE) were evaluated in chickens following oral infection with Eimeria (E.) tenella. This study was conducted on the 3-day-old chickens (n=30).
Sunhwa Hong, Gi-Wook Oh, Won-Guk Kang, Okjin Kim   +3 more
doaj   +1 more source

Neuron‐Derived Vesicular circMagi1 Restrains Vascular Repair After Ischemic Stroke by Promoting TRIM65‐Mediated ANXA2 Degradation

Advanced Science, EarlyView.
After ischemic stroke, injured neurons transfer circMagi1 to endothelial cells through extracellular vesicles. Within endothelial cells, circMagi1 binds ANXA2 and enhances its engagement with TRIM65, promoting ANXA2 ubiquitination and proteasomal degradation to constrain angiogenic repair.
Youkun Bi, Qun Liu, Baohua Zou, Wenyuan Wang, Xinlong Qiao, Lin Gao, Chaoxu Miao, Ningning Huang, Shuqing Tang, Rui Guo, Changqing Zeng, Ce Jia, Yuanchao Xue, Xuejun Guo, Jianjun Chen, Huiwen Wang, Guangju Ji   +16 more
wiley   +1 more source

Developmental Trajectory of Auditory Brainstem Deficits in a Mouse Model of Fetal Alcohol Spectrum Disorders. [PDF]

Dev Neurobiol
ABSTRACT Individuals with fetal alcohol spectrum disorders exhibit impaired auditory processing and atypical auditory behaviors across the disorder's spectrum. Although low to moderate prenatal alcohol exposure (PAE) is a prevalent type of exposure, the developmental trajectory of auditory processing deficits resulting from this level of exposure ...
Douchey M, Huntwork S, Sandstedt C, Padmashri R.   +3 more
europepmc   +2 more sources

Comparison of refractive and visual acuity results after Contoura® Vision topography-guided LASIK planned with the Phorcides Analytic Engine to results after wavefront-optimized LASIK in eyes with oblique astigmatism.

PLoS ONE, 2022
PurposeTo compare visual acuity and refractive results between topography-guided laser in situ keratomileusis (LASIK) planned with the Phorcides Analytic Engine (PAE) to results after wavefront-optimized (WFO) LASIK in subjects with preoperative oblique ...
Phillip Brunson, Paul M Mann, Paul Michael Mann, Richard Potvin   +3 more
doaj   +1 more source

Datenreport zum Forschungsprojekt Politisch-Administrative Elite (PAE) zu Bundesministerien

Die PAE-Umfrage zu den Bundesministerien ist Teil des Forschungsprojekts „Politisch-Administrative Elite“ (PAE). Dieses knüpft an die Comparative Elite Study (CES) der 1970er und 1980er Jahre an (Aberbach et al., 1981; Mayntz & Derlien, 1989).
Brockstedt, Freya Ch., Klenk, Tanja, Veit, Sylvia, Papenfuß, Ulf, Felgendreher, Nina, Döhler, Marian, Beneke, Jasmin T.   +6 more
core   +1 more source