Results 1 to 10 of about 2,661 (192)

Paeonol Attenuates Hepatic Ischemia/Reperfusion Injury by Modulating the Nrf2/HO-1 and TLR4/MYD88/NF-κB Signaling Pathways

Antioxidants, 2022
Hepatic ischemia/reperfusion (HIR) is the most common type of liver injury following several clinical situations. Modulating oxidative stress and inflammation by Nrf2/HO-1 and TLR4/MYD88/NF-κB pathways, respectively, is involved in alleviating HIR injury.
Mohamed A Morsy, Katharigatta N Venugopala, Seham A Abdel-Gaber   +2 more
exaly   +4 more sources

Paeonol eradicates biofilm in porcine-source Escherichia coli by targeting the quorum sensing system [PDF]

BMC Veterinary Research
Background Natural active compounds hold significant potential to overcome biofilm-mediated resistance, offering a promising therapeutic strategy for combating bacterial biofilms resistance.
Hongzao Yang, Yuan Liang, Zhuo Yang, Lin Liu, Lei Ran, Jingjing Liu, Chengjun Ma, Wei Wei, Suhui Zhang, Maixun Zhu, Hongwei Chen   +10 more
doaj   +3 more sources

Evaluation of paeonol skin-target delivery from its microsponge formulation: in vitro skin permeation and in vivo microdialysis. [PDF]

PLoS ONE, 2013
The aim of the present study was to design a novel topical skin-target drug-delivery system, the paeonol microsponge, and to investigate its drug-release patterns in dosage form, both in vitro and in vivo.
Sha-Sha Li, Guo-Feng Li, Li Liu, Xiao Jiang, Bin Zhang, Zhi-Gang Liu, Xue-Ling Li, Li-Dong Weng, Ting Zuo, Qiang Liu   +9 more
doaj   +2 more sources

Paeonol promotes Opa1-mediated mitochondrial fusion via activating the CK2α-Stat3 pathway in diabetic cardiomyopathy

Redox Biology, 2021
Diabetes disrupts mitochondrial function and often results in diabetic cardiomyopathy (DCM). Paeonol is a bioactive compound that has been reported to have pharmacological potential for cardiac and mitochondrial protection. This study aims to explore the
Jianming Pei, Juan Li, Feng Fu
exaly   +3 more sources

Paeonol alleviates granulosa cell senescence in laying chickens via the PI3K/Akt/mTOR signaling pathway [PDF]

Poultry Science
Background: Ovarian aging compromises reproductive health and reduces egg production, posing a persistent challenge to the poultry industry. Mitochondrial dysfunction in granulosa cells (GCs) accelerates reactive oxygen species (ROS) accumulation and ...
Yingyu Xiao, Qiongyu Yuan, Xiangyu Cai, Zhaoyu Yang, Wanyue Gao, Jing Dong, Weidong Zeng, Caiqiao Zhang, Yuling Mi   +8 more
doaj   +2 more sources

Paeonol ameliorates ferroptosis and inflammation in chondrocytes through AMPK/Nrf2/GPX4 pathway [PDF]

Frontiers in Pharmacology
IntroductionChondrocyte ferroptosis is an important component of the pathogenesis of osteoarthritis. Paeonol, the main pharmacologically active ingredient of the Paeonia suffruticosa Andrews, is a natural radical scavenger with potent biological ...
Shuwei Gong, Shuwei Gong, Shuang Lang, Xuesheng Jiang, Xuesheng Jiang, Xiongfeng Li, Xiongfeng Li   +6 more
doaj   +2 more sources

Effect of Paeonol on Antioxidant and Immune Regulatory Activity in Hepatocellular Carcinoma Rats

Molecules, 2012
The study investigated the immunity and antioxidant potential of paeonol by employing a hepatocellular carcinoma (HCC) rat model. Three doses of paeonol (20, 40, 60 mg/kg b.w.
Guangshun Yang
exaly   +3 more sources

Paeonol inhibits the Glycolysis in oral squamous cell carcinoma though suppressing NAT10-mediated ac4C modification [PDF]

BMC Cancer
Background Oral squamous cell carcinoma (OSCC) is the most common malignant tumor of the oral and maxillofacial regions. Paeonol, derived from Moutan Cortex, has diverse pharmacological effects including anti-inflammatory and anticancer activities. The N-
Kang Yang, Baosen Yue, Huan Tian, Lu Wang, Xiao Yang, Weiying Zhang   +5 more
doaj   +2 more sources

Antifungal and Antibiofilm Efficacy of Paeonol Treatment Against Biofilms Comprising Candida albicans and/or Cryptococcus neoformans

Frontiers in Cellular and Infection Microbiology, 2022
Fungal populations are commonly found in natural environments and present enormous health care challenges, due to increased resistance to antifungal agents.
Weidong Qian, Xinchen Li, Qiming Liu, Jiaxing Lu, Ting Wang, Qian Zhang   +5 more
doaj   +1 more source

Paeonol Ameliorates Chronic Itch and Spinal Astrocytic Activation via CXCR3 in an Experimental Dry Skin Model in Mice

Frontiers in Pharmacology, 2022
Paeonol is a bioactive phenol presents mainly in Paeonia suffruticosa Andr. (Paeoniaceae), Paeonia lactiflora Pall., and Dioscorea japonica Thunb. (Dioscoreaceae), harboring various pharmacological activities including anti-inflammatory, antioxidant ...
Wen Wang, Wen Wang, Qiaoyun Li, Qiaoyun Li, Zhongqiu Zhao, Zhongqiu Zhao, Yutong Liu, Yi Wang, Hui Xiong, Hui Xiong, Zhinan Mei, Zhinan Mei   +11 more
doaj   +1 more source