Pharmacokinetics, Tissue Distribution and Excretion of Paeonol and Its Major Metabolites in Rats Provide a Further Insight Into Paeonol Effectiveness [PDF]
Frontiers in Pharmacology, 2020 Paeonol is a major bioactive ingredient in Moutan Cortex (the root barks of Paeonia suffruticosa Andrews) and exhibited a wide range of bioactivities such as anti-inflammation, anti-oxidation, hypoglycemic effect, analgesic, and others.
Feng Qiu, Liqin Ding
exaly +5 more sources
Redox Biology, 2021 Diabetes disrupts mitochondrial function and often results in diabetic cardiomyopathy (DCM). Paeonol is a bioactive compound that has been reported to have pharmacological potential for cardiac and mitochondrial protection. This study aims to explore the
Jianming Pei, Juan Li, Feng Fu
exaly +3 more sources
Biological Activities of Paeonol in Cardiovascular Diseases: A Review [PDF]
Molecules, 2021 Paeonol is a naturally existing bioactive compound found in the root bark of Paeonia suffruticosa and it is traditionally used in Chinese medicine for the prevention and management of cardiovascular diseases.
Shalini Vellasamy +5 more
doaj +3 more sources
Paeonol eradicates biofilm in porcine-source Escherichia coli by targeting the quorum sensing system [PDF]
BMC Veterinary ResearchBackground Natural active compounds hold significant potential to overcome biofilm-mediated resistance, offering a promising therapeutic strategy for combating bacterial biofilms resistance.
Hongzao Yang +10 more
doaj +2 more sources
Paeonol alleviates granulosa cell senescence in laying chickens via the PI3K/Akt/mTOR signaling pathway [PDF]
Poultry ScienceBackground: Ovarian aging compromises reproductive health and reduces egg production, posing a persistent challenge to the poultry industry. Mitochondrial dysfunction in granulosa cells (GCs) accelerates reactive oxygen species (ROS) accumulation and ...
Yingyu Xiao +8 more
doaj +2 more sources
Paeonol ameliorates ferroptosis and inflammation in chondrocytes through AMPK/Nrf2/GPX4 pathway [PDF]
Frontiers in PharmacologyIntroductionChondrocyte ferroptosis is an important component of the pathogenesis of osteoarthritis. Paeonol, the main pharmacologically active ingredient of the Paeonia suffruticosa Andrews, is a natural radical scavenger with potent biological ...
Shuwei Gong +6 more
doaj +2 more sources
Antifungal activity of paeonol against Botrytis cinerea by disrupting the cell membrane and the application on cherry tomato preservation [PDF]
Frontiers in MicrobiologyBotrytis cinerea may cause gray mold in fruits and vegetables. Paeonol, an active component of traditional Chinese medicine, could suppress various microbial growth. However, reports on its effect on B. cinerea have not yet been documented. In this paper,
Yang Jiao +6 more
doaj +2 more sources
A review on therapeutical potential of paeonol in atherosclerosis
Frontiers in Pharmacology, 2022 The morbidity and mortality of atherosclerotic cardiovascular disease (ASCVD) is increasing year by year. Cortex Moutan is a traditional Chinese medicinal herb that has been widely used for thousands of years to treat a wide variety of diseases in ...
Wei Yu +4 more
doaj +3 more sources
Review of the Protective Mechanism of Paeonol on Cardiovascular Disease
Drug Design, Development and Therapy, 2023 Cardiovascular disease (CVD) is one of the leading causes of death in the world. Paeonol(Pae) is a phenolic component extracted from peony bark, peony root and Xu Changqing. Studies have shown that Pae can protect cardiomyocytes by inhibiting oxidative stress, promoting mitochondrial fusion, regulating mitochondrial autophagy and inhibiting ...
Yang,Chunkun +5 more
exaly +5 more sources
Insight into the immunomodulatory and chemotherapeutic mechanisms of paeonol (Review). [PDF]
Med Int (Lond)Paeonol a, pharmacologically active constituent obtained from the root bark of Paeonia suffruticosa has been extensively utilized as a traditional Chinese medicine for the treatment, prevention and control of several diseases for years. Paeonol has been reported to possess key immunomodulatory properties; however, the underlying mechanisms involved in ...
Barnes P +7 more
europepmc +3 more sources