Results 31 to 40 of about 2,001 (169)

Paeonol Disrupts the Integrity of Aspergillus flavus Cell Walls via Releasing Surface Proteins, Inhibiting the Biosynthesis of β-1,3-Glucan and Promoting the Degradation of Chitin, and an Identification of Cell Surface Proteins

Foods, 2021
Paeonol can effectively inhibit Aspergillus flavus (A. flavus) via damaging cell walls. In this work, paeonol treatment remarkably destroyed both the outer amorphous layer and the inner fibrous layer of cell walls.
Qian Li, Ying Zhao, Yanli Xie
doaj   +1 more source

Paeonol regulates NLRP3 inflammasomes and pyroptosis to alleviate spinal cord injury of rat

BMC Neuroscience, 2022
Background Spinal cord injury (SCI) is a life-threatening traumatic disorder. Paeonol has been confirmed to be involved in a variety of diseases. The purpose of this study is to investigate the role of paeonol on SCI progression.
Houling Zhao, Xi Wang, Shuheng Liu, Qingguo Zhang   +3 more
doaj   +1 more source

Paeonol Attenuates Quorum-Sensing Regulated Virulence and Biofilm Formation in Pseudomonas aeruginosa

Frontiers in Microbiology, 2021
With the prevalence of multidrug-resistant bacteria and clinical -acquired pathogenic infections, the development of quorum-sensing (QS) interfering agents is one of the most potential strategies to combat bacterial infections and antibiotic resistance ...
Dan Yang, Suqi Hao, Ling Zhao, Fei Shi, Gang Ye, Yuanfeng Zou, Xu Song, Lixia Li, Zhongqiong Yin, Xiaoli He, Shiling Feng, Helin Chen, Yu Zhang, Yuanze Gao, Yinglun Li, Huaqiao Tang   +15 more
doaj   +1 more source

Paeonol Protects Against Myocardial Ischemia/Reperfusion-Induced Injury by Mediating Apoptosis and Autophagy Crosstalk

Frontiers in Pharmacology, 2021
Many studies have shown that crosstalk exists between apoptosis and autophagy, despite differences in mechanisms between these processes. Paeonol, a major phenolic compound isolated from Moutan Cortex Radicis, the root bark of Paeonia × suffruticosa ...
Chin-Feng Tsai, Chin-Feng Tsai, Hsing-Hui Su, Ke‐Min Chen, Jiuan-Miaw Liao, Yi-Ting Yao, Yi-Hung Chen, Yi-Hung Chen, Yi-Hung Chen, Meilin Wang, Ya-Chun Chu, Yi-Hsin Wang, Yi-Hsin Wang, Shiang-Suo Huang, Shiang-Suo Huang, Shiang-Suo Huang   +15 more
doaj   +1 more source

Paeonol ameliorates hippocampal neuronal damage by inhibiting GRM5/GABBR2/β-arrestin2 and activating the cAMP-PKA signaling pathway in premenstrual irritability rats

Brain Research Bulletin, 2023
Premenstrual dysphoric disorder (PMDD) is a periodic psychiatric disorder with high prevalence in women of childbearing age, seriously affecting patients' work and life.
Enhua Wei, Aiying Gao, Xiaofei Mu, Songlin Qu, Caixing Yang, Fengling Li, Shujing Li, Xuehuan Liu, Chunhong Song, Yinghui Guo   +9 more
doaj   +1 more source

Paeonol Protects Against Methotrexate-Induced Nephrotoxicity via Upregulation of P-gp Expression and Inhibition of TLR4/NF-κB Pathway

Frontiers in Pharmacology, 2022
Methotrexate (MTX) is a well-known anticancer drug that causes nephrotoxicity as a side effect. To investigate the mechanisms by which paeonol, a natural phenolic compound, can protect against MTX-induced nephrotoxicity, paeonol (100 mg/kg/day orally ...
Mohamed A. Morsy, Mohamed A. Morsy, Azza A. K. El-Sheikh, Azza A. K. El-Sheikh, Sara Mohamed Naguib Abdel-Hafez, Mahmoud Kandeel, Mahmoud Kandeel, Seham A. Abdel-Gaber   +7 more
doaj   +1 more source

UPLC-Q-TOF/MS Based Plasma Metabolomics for Identification of Paeonol’s Metabolic Target in Endometriosis

Molecules, 2023
Endometriosis is a common gynecological illness in women of reproductive age that significantly decreases life quality and fertility. Paeonol has been shown to play an important part in endometriosis treatments.
Jing Liu, Dongxia Yang, Chengyu Piao, Xu Wang, Xiaolan Sun, Yongyan Li, Shuxiang Zhang, Xiuhong Wu   +7 more
doaj   +1 more source

Paeonol attenuates retinopathy in streptozotocin-induced diabetes in rats by regulating the oxidative stress and polyol pathway

Frontiers in Pharmacology, 2022
The current research work was planned to study the effects of paeonol in the management of diabetic retinopathy. Diabetes was induced in male Sprague Dawley rats using Streptozotocin (55 mg/kg, i.p.). After 4 weeks, the diabetic animals were treated with
Kaveri M. Adki, Yogesh A. Kulkarni
doaj   +1 more source

Beneficial Effects Exerted by Paeonol in the Management of Atherosclerosis [PDF]

Oxidative Medicine and Cellular Longevity, 2018
Atherosclerosis, a chronic luminal stenosis disorder occurred in large and medium arteries, is the principle pathological basis of cardiovascular diseases with the highest morbidity and mortality worldwide. In oriental countries, traditional Chinese medicine Cortex Moutan has been widely used for the treatment of atherosclerosis‐related illnesses for ...
Li Lu, Yating Qin, Chen Chen, Xiaomei Guo   +3 more
openaire   +2 more sources

Modulating Effect of Paeonol on Piglets With Ulcerative Colitis

Frontiers in Nutrition, 2022
Piglet enteritis is a major problem that needs to be solved urgently in modern pig production. Paeonol (Pae) has been used as a novel treatment option due to its good medicinal value. This study purported to elucidate the regulatory mechanism of Pae on dextran sodium sulfate (DSS)-induced ulcerative colitis (UC) in weaned piglets.
Shanshan Wang, Miaomiao Bai, Qingyan Shu, Zhengan Liu, Yirui Shao, Kang Xu, Xia Xiong, Hongnan Liu, Yao Li   +8 more
openaire   +3 more sources