Results 51 to 60 of about 2,001 (169)

Role of Paeonol in an Astrocyte Model of Parkinson’s Disease [PDF]

Medical Science Monitor, 2017
BACKGROUND Parkinson's disease (PD) is characterized by a progressive degeneration of dopaminergic (DA) neurons in the substantia nigra pars compacta (SNc). Inflammation and neural degeneration are implicated in the pathogenesis of PD. Paeonol has been verified to attenuate inflammation. MATERIAL AND METHODS 1-methyl-4-phenylpyridnium ion (MPP+, 100 μM)
Ye, Maosheng, Yi, Yuxin, Wu, Shixing, Zhou, Yong, Zhao, Dongjie   +4 more
openaire   +2 more sources

Research on the Mechanism of Natural Products Acting on Chronic Obstructive Pulmonary Disease

Food Science &Nutrition, Volume 14, Issue 7, July 2026.
This figure illustrates that approximately 80 natural compounds exert therapeutic effects against chronic obstructive pulmonary disease by targeting pathological mechanisms such as airway inflammation, oxidative stress, airway remodeling, mucus hypersecretion, emphysema, protease–antiprotease imbalance, apoptosis, and autophagy.
Shuna Wei, Xiaoju Liu
wiley   +1 more source

Antifungal activity and potential mechanism of paeonol against Fusarium graminearum and the application on wheat grains and steamed bread

Grain & Oil Science and Technology
Fusarium graminearum (F. graminearum) is a severe phytopathogen threatening agriculture production and food security. Paeonol, serves as a plant-derived natural component, is a promising antifungal agent.
Yiming Zhang, Hongying Xiao, Roland Ernest Poms, Qian Li, Renyong Zhao   +4 more
doaj   +1 more source

Phytochemicals in MASLD: A Focused Review of Gut Microbiome‐Linked Mechanisms

Phytotherapy Research, Volume 40, Issue 7, Page 4041-4055, July 2026.
ABSTRACT Metabolic dysfunction‐associated steatotic liver disease (MASLD) has emerged as a major global health burden, yet effective pharmacological options remain limited. Recent advances highlight the gut microbiome as a key modulator of liver metabolism, inflammation, and fibrosis, making it a promising therapeutic target.
Jeong In Seo, Su Min Kim, Hye Hyun Yoo
wiley   +1 more source

Paeonol administration alleviates cognitive deficits and attenuates neural pathological changes in APP/PS1 mice

Journal of Integrative Neuroscience, 2021
Alzheimer’s disease typically presents with impaired cognition and pathological morphologic changes, including the accumulation of amyloid-β plaques. Disease-modifying drugs are in urgent need as neuroprotective therapies.
Shengxi Meng, Bing Wang, Wentao Li   +2 more
doaj   +1 more source

Natural Products as Modulators of ABC Transporters in Breast Cancer

Phytotherapy Research, Volume 40, Issue 7, Page 4611-4637, July 2026.
ABSTRACT Breast cancer remains a significant global health challenge, with high incidence and mortality rates despite advancements in early detection and treatment. Multidrug resistance (MDR), particularly in aggressive subtypes like triple‐negative breast cancer (TNBC), continues to hinder effective therapy.
Yoganishalini Sagadevan, Reyhaneh Farghadani, Ammu K. Radhakrishnan   +2 more
wiley   +1 more source

Mechanisms of Gui Zhi Fu Ling Formula in Liver Fibrosis: Metabolomics and Gut Microbiota Analysis

eFood, Volume 7, Issue 3, June 2026.
Our study was based on the efficacy of the phenotype in an animal model and used multi‐omics to explore the mechanism of action of the compound. We found that Gui Zhi Fu Ling Formula may ameliorate hepatic fibrosis potentially associated with increased hepatic EPA and the expression of gut Pseudomonas.
Xiaoliang Deng, Yanqun Luo, Ying Gao, Yi Su, Haiping Xue, Tao Wu   +5 more
wiley   +1 more source

Protective Mechanism of Auricularia auricula Polysaccharides Against Acute Alcoholic Liver Injury Is Related to Different Consumption Doses

eFood, Volume 7, Issue 2, April 2026.
The study investigated the protective mechanisms of low‐, medium‐, and high‐dose Auricularia auricula polysaccharide (AAP) against acute alcoholic liver injury (AALI) by correlating hepatic biochemical indices with intestinal flora. ABSTRACT This study investigated the dose‐dependent protective effects of Auricularia auricula polysaccharides (AAP ...
Haili Niu, Fangjia Zhao, Zeyu Hu, Qi Wang, Yuan Li, Ivan Kurtovic, Yahong Yuan, Tianli Yue   +7 more
wiley   +1 more source

Conference Report: Sixth Annual Young Researcher Forum of the Japan Society of Medical and Pharmaceutical Sciences for Traditional Medicine

Traditional &Kampo Medicine, Volume 13, Issue 1, April 2026.
ABSTRACT Background Nine young researchers presented their studies in the field of traditional Japanese Kampo medicine (Wakan‐yaku) at the Sixth Annual Young Researcher Forum held the day before the 2025 annual meeting of the Japan Society of Medical and Pharmaceutical Sciences for Traditional Medicine. Main Presentations Dr.
Tetsuhiro Yoshino, Kensuke Nakajima, Kousuke Araki, Tomoki Sekiya, Sakura Takamatsu, Motoya Miyahara, Ryuya Takada, Ryohei Nishimoto, Takumi Nagamatsu, Mebuki Hama, Ximeng Yang, Kazuhito Murakami, Mayumi Kamigaki, Hirokazu Ando, Souichi Nakashima   +14 more
wiley   +1 more source

Targeting Ferroptosis With Natural Products for the Treatment of Skeletal System Disease: An Updated Review

Journal of Cellular and Molecular Medicine, Volume 30, Issue 7, April 2026.
ABSTRACT Skeletal system diseases, encompassing chronic disorders of the skeletal system which commonly include osteoarthritis, rheumatoid arthritis, osteoporosis and osteosarcoma. Their incidence rates have been increasing in recent years, resulting in significant social and economic burdens.
Qian Yi, Jinye Li, Guotian Luo, Jiachen Li, Dahang Yang, Wei Sun, Weichao Sun, Wei You, Lei Yang   +8 more
wiley   +1 more source