Results 71 to 80 of about 2,661 (192)

The effects of paeonol on the electrophysiological properties of cardiac ventricular myocytes

, 2006
Previous studies have shown that "Mudanpi", a Chinese herbal medicine, has a significant cardioprotective effect against myocardial ischaemia. Based on these findings we hypothesised that paeonol, the main component of Mudanpi, might have an effect on ...
Gurney, Alison M.; id_orcid, Bates, Susan, Ma, Yu ling, Gurney, A.M., Ma, Y.L., Bates, S.   +5 more
core   +1 more source

Paeonol administration alleviates cognitive deficits and attenuates neural pathological changes in APP/PS1 mice

Journal of Integrative Neuroscience, 2021
Alzheimer’s disease typically presents with impaired cognition and pathological morphologic changes, including the accumulation of amyloid-β plaques. Disease-modifying drugs are in urgent need as neuroprotective therapies.
Shengxi Meng, Bing Wang, Wentao Li   +2 more
doaj   +1 more source

Molecular Targets and Potential Mechanisms of Luteolin Against Cervical Carcinoma: Integrative Approach Combining Network Pharmacology, Molecular Docking, Molecular Dynamics Simulations, and In Vitro Validation

Chemistry &Biodiversity, Volume 23, Issue 10, October 2026.
Based on network pharmacology, molecular dynamics simulation, and cell biology experimental techniques, the natural bioactive component with potential therapeutic effects on cervical carcinoma in olive was predicted. Luteolin can inhibit the proliferation and lipid droplet accumulation of Hela cells, and reduce the expression of the key target CXCL8 at
Xinyu Pan, Dan Liu, Junliang Chen, Hanlu Deng, Xiangyu Cao   +4 more
wiley   +1 more source

Role of Paeonol in an Astrocyte Model of Parkinson’s Disease [PDF]

Medical Science Monitor, 2017
BACKGROUND Parkinson's disease (PD) is characterized by a progressive degeneration of dopaminergic (DA) neurons in the substantia nigra pars compacta (SNc). Inflammation and neural degeneration are implicated in the pathogenesis of PD. Paeonol has been verified to attenuate inflammation. MATERIAL AND METHODS 1-methyl-4-phenylpyridnium ion (MPP+, 100 μM)
Ye, Maosheng, Yi, Yuxin, Wu, Shixing, Zhou, Yong, Zhao, Dongjie   +4 more
openaire   +2 more sources

Mitochondrial Fusion and Fission in Age‐Related Cardio‐Cerebral Diseases: Mechanisms and Interventions

Aging Cell, Volume 25, Issue 10, October 2026.
Mitochondrial fission‐fusion imbalance contributes to age‐related cardio‐cerebral diseases like Alzheimer's disease, Parkinson's disease, Cerebral Infarction, Arteriosclerosis, Myocardial Infarction, Cardiac valve disease, Hypertension, and Cardiomyopathy. This review summarizes its regulatory mechanisms and interventions.
Yuyao Yin, Zijian Li
wiley   +1 more source

The Skin‐Lightening Efficacy and Mechanisms of Botanical Extracts: A Comprehensive Review

Journal of Cosmetic Dermatology, Volume 25, Issue 10, October 2026.
ABSTRACT Background Skin pigmentation is regulated by a complex network involving melanogenesis, melanosome transfer, oxidative stress, environmental stimuli, and epidermal turnover. Botanical extracts and phytochemicals have attracted increasing interest as potential skin‐lightening agents. This review evaluates their efficacy, mechanisms, and safety.
Siting Yang, Mingning Ding, Chenglong Ye, Jingning Shen, Lihua Zhang, Anquan Yang, Lihao Gu   +6 more
wiley   +1 more source

Eutectic-based liposome as a potential delivery system of paeonol

RSC Advances, 2021
A THEDES based on paeonol and lauric acid was constructed and showed potential applicability for the delivery of paeonol.
Jieyu Wu, Suqin Yang, Tianxiang Yin, Xiaoyong Wang   +3 more
openaire   +3 more sources

Paeonol suppress chondrosarcoma metastasis through up-regulation of miR-141 by modulating the PKC? and c-Src signaling pathway

, 2014
[[abstract]]Chondrosarcoma, a primary malignant bone cancer, has potential for local invasion and distant metastasis, especially to the lungs. Patients diagnosed with it show poor prognosis.
Hor, Chi-Ting;Horng, Chi-Ting;Shi, Po-Chuen;Shieh, Po-Chuen;Tan, Tzu-Wei;Tan, Tzu-Wei;Yan, Wei-Hung;Yang, Wei-Hung;湯智昕;Chih-Hsin, Tang;*
core   +1 more source

Inhibition effects of paeonol on mice bearing EMT6 breast cancer through inducing rumor cell apoptosis [PDF]

, 2014
Paeonol, a phenolic component from the root bark of Paeonia moutan, has been identified to possess antitumor effects on mice bearing EMT6 breast cancer in our previous studies. However, the underlying mechanisms remain unknown.
Dong, Hang, Wang, Molin, Luo, Wenzhe, Wang, Jianjie, Li, Lijiang, Zhou, Shaobo, Song, Hanjun   +6 more
core   +2 more sources

Retracted: Role of Paeonol in an Astrocyte Model of Parkinson Disease

Medical Science Monitor, 2021
The authors wish to retract the article. In this article, they found that astrocytes that were pretreated with paeonol significantly rescued MPP+-induced cell viability reduction, and inhibited up-regulation of cell apoptosis, caspase-1 activity, COX2, iNOS, and Bax/Bcl-2 ratio, as well as p-JNK and p-ERK.
Ye, Maosheng, Yi, Yuxin, Wu, Shixing, Zhou, Yong, Zhao, Dongjie   +4 more
openaire   +3 more sources