Results 61 to 70 of about 2,661 (192)

Development of Paeonol Liposomes: Design, Optimization, in vitro and in vivo Evaluation

International Journal of Nanomedicine, 2022
Shan Huang,1 Bingtao Zhai,1 Yu Fan,2 Jing Sun,1 Jiangxue Cheng,1 Junbo Zou,1 Xiaofei Zhang,1 Yajun Shi,1 Dongyan Guo1 1Shaanxi Province Key Laboratory of New Drugs and Chinese Medicine Foundation Research, College of Pharmacy, Shaanxi University of ...
Huang S, Zhai B, Fan Y, Sun J, Cheng J, Zou J, Zhang X, Shi Y, Guo D   +8 more
doaj  

CYP1A2 is the major isoform responsible for paeonol O-demethylation in human liver microsomes

, 2009
1. Paeonol, the primary active component of a traditional Chinese medicine Moutan Cortex, has a wide range of pharmacological activities. In the present study, the metabolism of paeonol by cytochrome P450s (CYPs) was investigated in human liver ...
Hu, Y., Li, W., 杨凌, He, Y. -Q., Liu, Y., Yang, L., Liu, H. -X., Y. Hu, H.-X. Liu, Y.-Q. He, W. Li, Y. Liu, L. Yang   +12 more
core   +1 more source

Paeonol at Certain Doses Alleviates Aggressive and Anxiety-Like Behaviours in Two Premenstrual Dysphoric Disorder Rat Models

Frontiers in Psychiatry, 2020
Premenstrual dysphoric disorder (PMDD) is a severe form of premenstrual syndrome (PMS), a common mental health disturbance associated with several periodic psychological symptoms in women.
Hao Zhang, Xiwen Geng, Xiwen Geng, Zifa Li, Zifa Li, Yaqiong Li, Kaiyong Xu, Kaiyong Xu, Hongyun Wu, Jinlu Xie, Peng Sun, Sheng Wei, Sheng Wei, Mingqi Qiao   +13 more
doaj   +1 more source

Protective Potentials of Natural Products Against Vascular Dementia: A Comprehensive Review of Experimental Studies

Phytotherapy Research, EarlyView.
ABSTRACT Vascular dementia (VaD), accounting for up to 20% of dementia cases globally, is primarily driven by chronic cerebral hypoperfusion (CCH), which leads to progressive cognitive impairment. Despite the increasing prevalence of VaD, effective treatments remain limited.
Jung‐Hoon Kim, Yongtaek Oh, Suin Cho
wiley   +1 more source

Paeonol alleviates migration and invasion of endometrial stromal cells by reducing HIF-1α-regulated autophagy in endometriosis

Frontiers in Bioscience-Landmark, 2021
Background: Dysregulated migration and invasion of endometrial stromal cells is implicated in the pathogenesis of endometriosis. Hypoxia functions as critical microenvironmental factor that results in promotion of endometrial stromal cells migration and ...
Conghui Pang, Zhijuan Wu, Xiaoyan Xu, Wenxiu Yang, Xiaoxuan Wang, Yinghua Qi   +5 more
doaj   +1 more source

Astragaloside IV and Ferroptosis Modulation in Pathological Cardiac Hypertrophy: Current Evidence, an Integrative Hypothesis, and Future Directions

Pharmacology Research &Perspectives, Volume 14, Issue 6, December 2026.
ABSTRACT Pathological cardiac hypertrophy is initially an adaptive response to sustained mechanical, neurohormonal, or metabolic stress; however, it can progress to fibrosis, contractile dysfunction, arrhythmia, and heart failure. Ferroptosis is a type of regulated cell death caused by iron‐dependent phospholipid peroxidation.
Pengbo Liu, Yongzhi Deng
wiley   +1 more source

Antitumor and apoptosis induction effects of paeonol on mice bearing EMT6 breast carcinoma [PDF]

, 2014
Paeonol is a major phenolic micromolecular component of Moutan cortex Radicis, a traditional Chinese Medicine. It has shown antitumor effects in previous studies; however, the underlying mechanisms remain unknown. This study investigated the mechanism by
Li, Kun, Ou, Yetao, Wang, Jianjie, Li, Qingwang, Zhou, Shaobo   +4 more
core   +1 more source

Beneficial Effect of Paeonol on Antibiotic-Associated Inflammatory Response in Mice with Diarrhea

, 2022
Diarrhea is a common adverse effect of antibiotics particularly that acts on anaerobes. Moutan Radicis Cortex (MRC) is an herbal medicine used for its anti-inflammatory and antibacterial actions.
Do Hwi Park, Jeon, Chan-Yong, Ki Sung Kang, You-Kyung Choi, Choi, You-Kyung, Chan-Yong Jeon, Myong Jin Lee, Kang, Bohyung, Park, Do Hwi, Bohyung Kang, Kang, Ki Sung, Lee, Myong Jin   +11 more
core   +1 more source

Corynoxine Inhibits Tumor Growth via Targeting NQO1 and Modulating the PTPA–NQO1/PP2A Switch to Activate PP2A

Advanced Science, Volume 13, Issue 60, 28 October 2026.
Corynoxine exerts potent broad‐spectrum anticancer activity by directly targeting NQO1. This interaction dissociates the oncogenic NQO1‐PTPA complex, releasing PTPA to robustly activate the tumor suppressor PP2A. Consequently, downstream Raf/MEK/ERK and PI3K/AKT signaling pathways are suppressed, downregulating c‐Myc and driving tumor regression ...
Guoqing Hou, Li Lin, Mengjie Xia, Ruohan Liang, Yueyue Zhang, Linna Du, Xuan Cao   +6 more
wiley   +1 more source

Nicotinamide and Sodium Butyrate Double the Pool of Treatment‐Exclusive Metabolites in the Endophytic Fungus Curvularia sp. G6‐32

Chemistry &Biodiversity, Volume 23, Issue 10, October 2026.
Epigenetic modulators nicotinamide and sodium butyrate reshape the chemical landscape of the endophytic fungus Curvularia sp. G6‐32. Combining the OSMAC strategy with UHPLC‐MS/MS metabolomics and molecular networking reveals a more than twofold rise in treatment‐exclusive metabolites, including diketopiperazines and potentially bioactive natural ...
Guilherme Edison Almeida Pega, Laís Stella Perassolli Nicchio, Andressa Domingos Polli, Francielli Alana Pereira Valeze, Évelin Lemos de Oliveira, Eduardo Cesar Meurer, Débora Cristina Baldoqui, João Lúcio Azevedo, Julio Cesar Polonio   +8 more
wiley   +1 more source