Results 61 to 70 of about 2,001 (169)

Cardioprotective Effect of Paeonol on Chronic Heart Failure Induced by Doxorubicin via Regulating the miR-21-5p/S-Phase Kinase-Associated Protein 2 Axis

Frontiers in Cardiovascular Medicine, 2022
BackgroundThis study primarily explored the role of paeonol in doxorubicin (DOX)-induced chronic heart failure (CHF), considering the cardioprotective effect of paeonol on an epirubicin-induced cardiac injury.MethodsDOX-induced CHF-modeled rats were ...
Cong Chen, Shuhong Liu, Gaozhen Cao, Yang Hu, Yang Hu, Run Wang, Min Wu, Mingya Liu, Kai Hang Yiu, Kai Hang Yiu   +9 more
doaj   +1 more source

Heat Stress Modulates WDR5‐Mediated H3K4me3 Modification to Induce Melanogenesis via Activating CX3CL1/CX3CR1 Axis

Advanced Science, Volume 13, Issue 7, 3 February 2026.
This study elucidates the mechanism by which heat stress regulates skin pigmentation: heat stress upregulates CX3CL1 through the MYC‐WDR5‐H3K4me3 axis, thereby activating the CX3CL1/CX3CR1‐JNK signaling pathway and ultimately promoting melanogenesis. These findings provide novel potential therapeutic targets for pigmentary skin disorders.
Yushan Zhang, Ling Jiang, Yibo Hu, Chuhan Fu, Jinhua Huang, Jing Chen, Qinghai Zeng   +6 more
wiley   +1 more source

Kaempferol Attenuates Oxidative Stress‐Induced Injury in Gastric Mucosal Cells by Activating Nrf2/GPX4 Axis to Inhibit Ferroptosis

Immunity, Inflammation and Disease, Volume 14, Issue 2, February 2026.
ABSTRACT Objective This study explores how Kaempferol (KAE) protects against oxidative stress‐induced damage by suppressing ferroptosis via the Nrf2/GPX4 axis in gastric mucosal cells. Methods Human gastric epithelial cells (GES‐1) were treated with H₂O₂ to induce oxidative damage, following pretreatment with varying doses of KAE.
Chao Luo, Jing Yan, Yun Shen, Zhiguang Sun, Xiong Xiao   +4 more
wiley   +1 more source

Traditional Chinese Medicine Monomers for Psoriasis: Mechanistic Insights, Evidence, and Translational Perspectives

Dermatologic Therapy, Volume 2026, Issue 1, 2026.
Psoriasis is a chronic inflammatory skin disease characterized by immune dysregulation and abnormal keratinocyte proliferation. Traditional Chinese medicine (TCM) monomers, including quercetin, rutin, paeonol, resveratrol, oxymatrine, and ginsenosides, have attracted increasing attention as potential therapeutic candidates. This review summarizes their
Wenfei Luo, Huijuan Shi, Suraiya Saleem
wiley   +1 more source

Albiflorin‐Mediated MAP2K1 Targeting and HIF‐1 Signaling Inhibition Contribute to the Therapeutic Efficacy in Hyperuricemia‐Associated Cognitive Impairment

Human Mutation, Volume 2026, Issue 1, 2026.
This study investigated the therapeutic effects and mechanisms of Paeonia suffruticosa fruit pod extract (EMP) and its main component albiflorin (AF) on hyperuricemia‐associated cognitive impairment (HUA‐CI). A HUA‐CI mouse model was established, with cognitive function evaluated via Morris water maze.
Huimin Xiao, Xinwen Huang, Rui Yao, Jincai Liu, Linrui Duan, Siwang Wang, Jinming Gao, Minghua Ren   +7 more
wiley   +1 more source

Orientin Mitigates High Glucose/Ox‐LDL–Triggered Endothelial Cell Injury and Atherosclerosis by Regulating MARCH8‐Mediated NLRP3 Inflammasome Activation

Mediators of Inflammation, Volume 2026, Issue 1, 2026.
Endothelial cells under oxidative stress and inflammation are vital contributors to the progression of atherosclerosis. Although Orientin possesses antioxidant and anti‐inflammatory activities, the effects of Orientin on oxidized low‐density lipoprotein and high glucose (ox‐LDL/HG)–triggered endothelial cell injury and diabetes‐accelerated ...
Qi Li, Min Gao, Ni Zhong, Liang-Rong Zhang, Mei-Dong Zhu, Wei-Jing Ge, Qian-Zhu Wang, Xin Chen, Lei Zhang, Fu-Chen Song, Han-Zhi Lu, Fumio Tsuji   +11 more
wiley   +1 more source

Spatiotemporal Heterogeneity of Macrophages in Acute Pancreatitis: From Inflammatory Initiators to Repair Coordinators and Targeted Therapeutics

Mediators of Inflammation, Volume 2026, Issue 1, 2026.
The current management of acute pancreatitis (AP) primarily relies on supportive measures, such as fluid resuscitation, nutritional support, and infection control. However, these approaches do not adequately address the core drivers of the disease. This limitation arises from an incomplete understanding of the progression from local injury to systemic ...
Xiang Lu, Yu Zeng, Li-hong Gan, Li Li, Jian-qin Liu, Xin Zhou, Xiao-ning Jin, Chao-li Jiang, Zhi Li, Zoltan Rakonczay Jr.   +9 more
wiley   +1 more source

Effect of Paeonol on Antioxidant and Immune Regulatory Activity in Hepatocellular Carcinoma Rats

Molecules, 2012
The study investigated the immunity and antioxidant potential of paeonol by employing a hepatocellular carcinoma (HCC) rat model. Three doses of paeonol (20, 40, 60 mg/kg b.w.
Guangshun Yang, Mingliang Ning, Bendong Chen   +2 more
doaj   +1 more source

Analysis of Chemical Components and Blood‐Absorbed Components in Youjing Granules by UHPLC‐Q‐Orbitrap‐MS

Analytical Science Advances, Volume 6, Issue 2, December 2025.
ABSTRACT This study investigates the chemical components of Youjing Granules (YG) and identifies blood‐absorbed components in rat serum following YG administration via gavage. Chemical components and blood‐absorbed components of YG were analysed and identified using ultra‐high‐performance liquid chromatography coupled with hybrid quadrupole‐orbitrap ...
Mingxin Guo, Jiaqi Zeng, Xuping Jiang, Wenjiao Zhu, Zhian Tang, Tieliang Ma   +5 more
wiley   +1 more source

Integrative Toxicology Profiling of Thuja sutchuenensis Essential Oil: From LD50 Safety Assessment to Hepatic Apoptosis and Gut Microbiota Modulation

Food Science &Nutrition, Volume 13, Issue 12, December 2025.
This study provides the first experimental evidence of Thuja sutchuenensis essential oil (TEO) toxicity, with an oral LD50 of ~3800 mg/kg in mice. Sub‐LD50 doses cause focal hepatic necrosis via apoptosis/oxidative stress–related pathways without systemic inflammation or renal injury.
Nana Long, Youwei Zuo, Renxiu Yao, Quan Yang, Jian Li, Xiao Zhang, Shiqi You, Yang Peng, Hongping Deng   +8 more
wiley   +1 more source