Results 41 to 50 of about 2,661 (192)

The Anti-atherosclerotic Effect of Paeonol against Vascular Smooth Muscle Cell Proliferation by Up-regulation of Autophagy via the AMPK/mTOR Signaling Pathway

Frontiers in Pharmacology, 2018
Introduction: Paeonol (2′-hydroxy-4′-methoxyacetophenone), isolated from moutan cortex, is an active component and has been shown to have anti-atherosclerotic and anti-proliferation effects on vascular smooth muscle cells (VSMCs).
Hongfei Wu, Hongfei Wu, Aiwei Song, Wenjun Hu, Min Dai, Min Dai   +5 more
doaj   +1 more source

Paeonol regulates NLRP3 inflammasomes and pyroptosis to alleviate spinal cord injury of rat

BMC Neuroscience, 2022
Background Spinal cord injury (SCI) is a life-threatening traumatic disorder. Paeonol has been confirmed to be involved in a variety of diseases. The purpose of this study is to investigate the role of paeonol on SCI progression.
Houling Zhao, Xi Wang, Shuheng Liu, Qingguo Zhang   +3 more
doaj   +1 more source

Paeonol Attenuates Quorum-Sensing Regulated Virulence and Biofilm Formation in Pseudomonas aeruginosa

Frontiers in Microbiology, 2021
With the prevalence of multidrug-resistant bacteria and clinical -acquired pathogenic infections, the development of quorum-sensing (QS) interfering agents is one of the most potential strategies to combat bacterial infections and antibiotic resistance ...
Dan Yang, Suqi Hao, Ling Zhao, Fei Shi, Gang Ye, Yuanfeng Zou, Xu Song, Lixia Li, Zhongqiong Yin, Xiaoli He, Shiling Feng, Helin Chen, Yu Zhang, Yuanze Gao, Yinglun Li, Huaqiao Tang   +15 more
doaj   +1 more source

The paeonol target gene autophagy-related 5 has a potential therapeutic value in psoriasis treatment [PDF]

, 2021
Background Paeonol is a potent therapy for psoriasis. This study aimed to screen out paeonol-targeted genes in psoriasis and validate the potential of using paeonol for the management of psoriasis.
Jiaan Zhang, Chunxiang Zhou, Chenxue Jiang, Hongqiao Shi, Qian Zhang   +4 more
core   +1 more source

Paeonol Protects Against Myocardial Ischemia/Reperfusion-Induced Injury by Mediating Apoptosis and Autophagy Crosstalk

Frontiers in Pharmacology, 2021
Many studies have shown that crosstalk exists between apoptosis and autophagy, despite differences in mechanisms between these processes. Paeonol, a major phenolic compound isolated from Moutan Cortex Radicis, the root bark of Paeonia × suffruticosa ...
Chin-Feng Tsai, Chin-Feng Tsai, Hsing-Hui Su, Ke‐Min Chen, Jiuan-Miaw Liao, Yi-Ting Yao, Yi-Hung Chen, Yi-Hung Chen, Yi-Hung Chen, Meilin Wang, Ya-Chun Chu, Yi-Hsin Wang, Yi-Hsin Wang, Shiang-Suo Huang, Shiang-Suo Huang, Shiang-Suo Huang   +15 more
doaj   +1 more source

Paeonol Protects Against Methotrexate-Induced Nephrotoxicity via Upregulation of P-gp Expression and Inhibition of TLR4/NF-κB Pathway

Frontiers in Pharmacology, 2022
Methotrexate (MTX) is a well-known anticancer drug that causes nephrotoxicity as a side effect. To investigate the mechanisms by which paeonol, a natural phenolic compound, can protect against MTX-induced nephrotoxicity, paeonol (100 mg/kg/day orally ...
Mohamed A. Morsy, Mohamed A. Morsy, Azza A. K. El-Sheikh, Azza A. K. El-Sheikh, Sara Mohamed Naguib Abdel-Hafez, Mahmoud Kandeel, Mahmoud Kandeel, Seham A. Abdel-Gaber   +7 more
doaj   +1 more source

Paeonol ameliorates hippocampal neuronal damage by inhibiting GRM5/GABBR2/β-arrestin2 and activating the cAMP-PKA signaling pathway in premenstrual irritability rats

Brain Research Bulletin, 2023
Premenstrual dysphoric disorder (PMDD) is a periodic psychiatric disorder with high prevalence in women of childbearing age, seriously affecting patients' work and life.
Enhua Wei, Aiying Gao, Xiaofei Mu, Songlin Qu, Caixing Yang, Fengling Li, Shujing Li, Xuehuan Liu, Chunhong Song, Yinghui Guo   +9 more
doaj   +1 more source

Neuroprotective effect of paeonol against isofluraneinduced neuroapoptosis and cognitive dysfunction [PDF]

, 2016
Purpose: To investigate whether paeonol affords neuroprotection against isoflurane-induced neurotoxicity.Methods: Separate groups of neonatal rat pups were administered paeonol (20, 40 or 80 mg/kg) from post-natal day 3 (P3) to post-natal day 15. On post-
Zhang, Jian-Xin, Zhang, Chuan-Yang, Li, Gang, Li, Zhi-Ying, Zhao, Liang, Cao, Gui-Lin   +5 more
core   +1 more source

Paeonol Induces Protective Autophagy in Retinal Photoreceptor Cells [PDF]

Frontiers in Pharmacology, 2021
Background: Retinal photoreceptor (RP) cells are widely involved in retina-related diseases, and oxidative stress plays a critical role in retinal secondary damage. Herein, we investigated the effectiveness and potential mechanisms of autophagy of paeonol (Pae) in terms of oxidation resistance.Methods: The animal model was induced by light damage (LD ...
Daowei Zhang, Jiawen Wu, Jihong Wu, Jihong Wu, Jihong Wu, Jihong Wu, Shenghai Zhang, Shenghai Zhang, Shenghai Zhang, Shenghai Zhang   +9 more
openaire   +3 more sources

Paeonol attenuates retinopathy in streptozotocin-induced diabetes in rats by regulating the oxidative stress and polyol pathway

Frontiers in Pharmacology, 2022
The current research work was planned to study the effects of paeonol in the management of diabetic retinopathy. Diabetes was induced in male Sprague Dawley rats using Streptozotocin (55 mg/kg, i.p.). After 4 weeks, the diabetic animals were treated with
Kaveri M. Adki, Yogesh A. Kulkarni
doaj   +1 more source