Results 21 to 30 of about 2,001 (169)

Paeonol for the Treatment of Atherosclerotic Cardiovascular Disease: A Pharmacological and Mechanistic Overview

Frontiers in Cardiovascular Medicine, 2021
With improvement in living standards and average life expectancy, atherosclerotic cardiovascular disease incidences and mortality have been increasing annually.
Min Wu, Zongliang Yu, Xiaoya Li, Xiaoya Li, Xiaonan Zhang, Songzi Wang, Shengjie Yang, Lanqing Hu, Longtao Liu   +8 more
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Pharmacokinetics of Purified Paeonol and Paeonol in Moutan Cortex Decoction and Rhubarbmoutan Decoction [PDF]

Pharmaceutica Analytica Acta, 2011
180 KM male mice of 22~28g body weight were divided into three groups randomly and purified paeonol, Moutan Cortex decoction and Rhubarbmoutan decoction were orally administered at equivalent doses of 10 mg·kg -1 paeonol. A sensitive HPLC method was established and evaluated for determining the concentrations of paeonol in mice ...
Wu Jing, Zhang Rui, Yuan Gui-yan
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Paeonol attenuates inflammation by confining HMGB1 to the nucleus [PDF]

Journal of Cellular and Molecular Medicine, 2021
AbstractInflammation is a biological process that exists in a large number of diseases. If the magnitude or duration of inflammation becomes uncontrolled, inflammation may cause pathological damage to the host. HMGB1 and NF‐κB have been shown to play pivotal roles in inflammation‐related diseases.
Jifei Miao, Jun Zhong, Jiao Lan, Sen Ye, Peng Ye, Siyan Li, Aijia You, Xianjie Chen, Xiaoyi Liu, Hui Li   +9 more
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The effect of dietary paeonol on growth performance, antioxidant enzyme activities and gene expressions of Genetic Improvement of Farmed Tilapia juveniles (Oreochromis niloticus)

Aquaculture Reports, 2022
This experiment was conducted to determine the effect of dietary paeonol levels on growth performance, serum biochemical parameters, antioxidant enzyme activities and transcriptional expression of antioxidant- and immune-related genes in Genetic ...
Yaxue Li, Xing Lu, Weihua Gao, Lijuan Yu, Hua Wen, Ming Jiang, Juan Tian, Fan Wu   +7 more
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Attenuating Oxidative Stress by Paeonol Protected against Acetaminophen-Induced Hepatotoxicity in Mice. [PDF]

PLoS ONE, 2016
Acetaminophen (APAP) overdose is the most frequent cause of drug-induced acute liver failure. The purpose of this study was to investigate whether paeonol protected against APAP-induced hepatotoxicity.
Yi Ding, Qing Li, Yuan Xu, Yuning Chen, Yue Deng, Feng Zhi, Ke Qian   +6 more
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Paeonol Suppresses Proliferation and Motility of Non-Small-Cell Lung Cancer Cells by Disrupting STAT3/NF-κB Signaling

Frontiers in Pharmacology, 2020
Background: Targeting inflammatory microenvironment is a promising anti-tumor strategy. Paeonol is a phenolic compound with effective anti-inflammatory and anti-tumor properties.
Lei Zhang, Lei Zhang, Wen-Xu Chen, Wen-Xu Chen, Ling-Li Li, Yu-Zhu Cao, Ya-Di Geng, Ya-Di Geng, Xiao-Jun Feng, Xiao-Jun Feng, Ai-Yun Wang, Zhao-Lin Chen, Zhao-Lin Chen, Yin Lu, Ai-Zong Shen, Ai-Zong Shen, Ai-Zong Shen   +16 more
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Antioxidant and Neuroprotective Effects of Paeonol against Oxidative Stress and Altered Carrier-Mediated Transport System on NSC-34 Cell Lines

Antioxidants, 2022
Paeonol is a naturally occurring phenolic agent that attenuates neurotoxicity in neurodegenerative diseases. We aimed to investigate the antioxidant and protective effects of paeonol and determine its transport mechanism in wild-type (WT; NSC-34/hSOD1WT)
Sana Latif, Seung-Hye Choi, Asmita Gyawali, Seung Jae Hyeon, Young-Sook Kang, Hoon Ryu   +5 more
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The Anti-atherosclerotic Effect of Paeonol against Vascular Smooth Muscle Cell Proliferation by Up-regulation of Autophagy via the AMPK/mTOR Signaling Pathway

Frontiers in Pharmacology, 2018
Introduction: Paeonol (2′-hydroxy-4′-methoxyacetophenone), isolated from moutan cortex, is an active component and has been shown to have anti-atherosclerotic and anti-proliferation effects on vascular smooth muscle cells (VSMCs).
Hongfei Wu, Hongfei Wu, Aiwei Song, Wenjun Hu, Min Dai, Min Dai   +5 more
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Paeonol Interferes With Quorum-Sensing in Pseudomonas aeruginosa and Modulates Inflammatory Responses In Vitro and In Vivo

Frontiers in Immunology, 2022
Developing quorum-sensing (QS) based anti-infection drugs is one of the most powerful strategies to combat multidrug-resistant bacteria. Paeonol has been proven to attenuate the QS-controlled virulence factors of P.
Huaqiao Tang, Dan Yang, Ling Zhu, Fei Shi, Gang Ye, Hongrui Guo, Huidan Deng, Ling Zhao, Zhiwen Xu, Yinglun Li   +9 more
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Antidepressant-like Effect of Paeonol [PDF]

Pharmaceutical Biology, 2006
AbstractThe current study investigated the putative antidepressant-like effect of paeonol, a phenolic component from the root bark of Paeonia suffruticosa. Andr. (Ranunculaceae), in mice or rats using the tail suspension test (TST) and forced swimming test (FST), two widely accepted pharmacological models for detecting antidepressant activity in modern
Weili Zhu, Shiping Ma, Rong Qu, Dali Kang   +3 more
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