Results 21 to 30 of about 2,661 (192)

Paeonol Disrupts the Integrity of Aspergillus flavus Cell Walls via Releasing Surface Proteins, Inhibiting the Biosynthesis of β-1,3-Glucan and Promoting the Degradation of Chitin, and an Identification of Cell Surface Proteins

Foods, 2021
Paeonol can effectively inhibit Aspergillus flavus (A. flavus) via damaging cell walls. In this work, paeonol treatment remarkably destroyed both the outer amorphous layer and the inner fibrous layer of cell walls.
Qian Li, Ying Zhao, Yanli Xie
doaj   +2 more sources

Transdermal delivery of paeonol using cubic gel and microemulsion gel [PDF]

International Journal of Nanomedicine, 2011
Maofu Luo1,2, Qi Shen1, Jinjin Chen11School of Pharmacy, Shanghai Jiao Tong University, Shanghai, 2Jiangxi University of Traditional Chinese Medicine, Nanchang, People’s Republic of ChinaBackground: The aim of this study was to develop new ...
Chen J, Shen Q, Luo M
doaj   +2 more sources

Antifungal activity and potential mechanism of paeonol against Fusarium graminearum and the application on wheat grains and steamed bread

Grain & Oil Science and Technology
Fusarium graminearum (F. graminearum) is a severe phytopathogen threatening agriculture production and food security. Paeonol, serves as a plant-derived natural component, is a promising antifungal agent.
Yiming Zhang, Hongying Xiao, Roland Ernest Poms, Qian Li, Renyong Zhao   +4 more
doaj   +2 more sources

Paeonol Inhibits Oxidized Low-Density Lipoprotein-Induced Vascular Endothelial Cells Autophagy by Upregulating the Expression of miRNA-30a

Frontiers in Pharmacology, 2018
Paeonol from Cortex Moutan root is a potential therapeutic agent for atherosclerosis (AS). However, its mechanisms of action are still not fully understood.
Chao Li, Li Yang, Hongfei Wu, Hongfei Wu, Min Dai, Min Dai, Min Dai   +6 more
doaj   +2 more sources

Fluorimetric analysis of paeonol in Chinese herbal medicine Cynanchi Paniculati Radix by aluminum ion-sensitized fluorescence

Acta Pharmaceutica Sinica B, 2012
A novel fluorimetric method for determination of paeonol, an active component of Chinese herbal medicine, is proposed. The method is based on the reaction of paeonol with aluminum ion in pH 4.4 HAc-NaAc buffer to form a fluorescent Al(III)-paeonol ...
Fei Yang, Cuige Liu, Yongju Wei
doaj   +2 more sources

Synthesis and Hepatotoxicity Evaluation of Paeonol Clofibrate. [PDF]

Chem Biodivers
CF‐Paeonol, a molecular hybrid of clofibric acid and paeonol, retains lipid‐lowering activity while producing markedly less hepatic injury than clofibrate (CF) in mice. Its benefits are accompanied by improved bile acid homeostasis, reduced oxidative stress and inflammation, decreased YY1 expression, and increased FXR expression, supporting molecular ...
Tu H, Ding L, Zheng J, Yang Y, Chen X, Song Y, Shi X, Wang C, Xu X, Liu J, Xie Y.   +10 more
europepmc   +2 more sources

Paeonol Alleviate Cisplatin- and Noise-Induced Hearing Loss by Preserving Hair Cell Ribosome Biogenesis. [PDF]

CNS Neurosci Ther
Paeonol protects against cisplatin‐ and noise‐induced hearing loss by mitigating oxidative damage and preserving protein homeostasis in cochlear hair cells, revealing a novel mechanism involving ribosome biogenesis. ABSTRACT Background Hearing loss primarily results from irreversible cochlear hair cell (HC) damage caused by factors such as noise, aging,
Xia M, Sun T, Hou W, Lou Y, Li Y, Jiang H, Chai H, Ma J, Xia M.   +8 more
europepmc   +2 more sources

Paeonol Derivative, 6′-Methyl Paeonol, Attenuates Aβ-Induced Pathophysiology in Cortical Neurons and in an Alzheimer’s Disease Mice Model

ACS Chemical Neuroscience
Herbs themselves and various herbal medicines are great resources for discovering therapeutic drugs for various diseases, including Alzheimer’s disease (AD), one of the common neurodegenerative diseases.
Guan-Chiun Lee (326129), Po-Chung Chien (17874291), Yenshou Lin (6111323), Yi-Ru Chen (407375), Chien-An Yao (590959), Jen-Hua Chuang (5212022), Wenwei Lin (278782), Pin-Jung Chen (5813375), Pei-Li Chou (10509938), Han-Jung Tsai (17874294)   +9 more
core   +3 more sources

Paeonol as a Multi-Target Therapy for Neurological Disorders: Mechanistic Insights Into Neuroprotection. [PDF]

Immun Inflamm Dis
Paeonol (PNL) exhibits neuroprotective effects by reducing oxidative stress, neuroinflammation, and apoptosis. It enhances antioxidant defenses (SOD and GSH), inhibits pro‐inflammatory pathways (NF‐κB and TLR4), and modulates apoptotic proteins (Bcl‐2 and Bax).
Al Hasan MS, Shahria N, Emon Y, Alshahrani MY, Mia E, Altemani FH, Suma RB, Sumaya UH, Uddin MB, Islam MT.   +9 more
europepmc   +2 more sources

Paeonol Attenuates Atherosclerosis by Inhibiting Vascular Smooth Muscle Cells Senescence via SIRT1/P53/TRF2 Signaling Pathway

Molecules
Atherosclerosis is a chronic inflammatory disease leading to various vascular diseases. Vascular smooth muscle cell (VSMC) senescence promotes atherosclerotic inflammation and the formation of plaque necrosis core, in part through telomere damage ...
Min Zhou, Xiaolin Ma, Menglong Gao, Hongfei Wu, Yarong Liu, Xiaoyan Shi, Min Dai   +6 more
doaj   +2 more sources