Results 11 to 20 of about 2,001 (169)

Paeonol inhibits the Glycolysis in oral squamous cell carcinoma though suppressing NAT10-mediated ac4C modification [PDF]

BMC Cancer
Background Oral squamous cell carcinoma (OSCC) is the most common malignant tumor of the oral and maxillofacial regions. Paeonol, derived from Moutan Cortex, has diverse pharmacological effects including anti-inflammatory and anticancer activities. The N-
Kang Yang, Baosen Yue, Huan Tian, Lu Wang, Xiao Yang, Weiying Zhang   +5 more
doaj   +2 more sources

Investigation of paeonol in dermatological diseases: an animal study review. [PDF]

Front Pharmacol
Cortex Moutan is the root bark of the buttercup plant Paeonia suffruticosa Andr, of Ranunculaceae family. It has been utilized in Chinese medicine for thousands of years to treat a multitude of diseases, and traditional Chinese documents allege that it has heat-clearing, antipyretic, anti-inflammatory and detoxicating properties. Paeonol is a bioactive
Ju J, Song T, Shi J, Li J.
europepmc   +4 more sources

Beyond Catalytic Therapy: Copper-Paeonol Nanozymes Disrupt Fascin-Mediated Actin Bundling to Suppress Tumor Growth and Metastasis. [PDF]

Adv Sci (Weinh)
Copper‐paeonol nanozymes target tumor‐specific reactive oxygen species generation and disrupt fascin‐mediated actin bundling, effectively suppressing tumor growth and metastatic colonization. Abstract Fascin, an actin‐bundling protein universally upregulated in metastatic tumors, drives tumor migration and invasion by promoting filopodia and ...
Zhang P, Li H, Wang Y, Xiang J, Fan L, Zhang S, Gao L, Dai H, Xi J.   +8 more
europepmc   +2 more sources

Paeonol Inhibits Cell Growth by Inducing Ferroptosis in Human Glioma Cells. [PDF]

Pharmacol Res Perspect
ABSTRACT Paeonol (PAE), a phenolic phytochemical derived from traditional Chinese medicinal plants, exhibits multifaceted pharmacological properties including demonstrated antitumor efficacy against hepatic, gastric, and breast carcinomas. However, its therapeutic potential in glioma remains unexplored.
Li X, Liao XQ, Chen WR, Wu T, Li JX, Wang L, He BS, Qin X, Luo JQ.   +8 more
europepmc   +2 more sources

Antifungal and Antibiofilm Efficacy of Paeonol Treatment Against Biofilms Comprising Candida albicans and/or Cryptococcus neoformans

Frontiers in Cellular and Infection Microbiology, 2022
Fungal populations are commonly found in natural environments and present enormous health care challenges, due to increased resistance to antifungal agents.
Weidong Qian, Xinchen Li, Qiming Liu, Jiaxing Lu, Ting Wang, Qian Zhang   +5 more
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Paeonol Ameliorates Chronic Itch and Spinal Astrocytic Activation via CXCR3 in an Experimental Dry Skin Model in Mice

Frontiers in Pharmacology, 2022
Paeonol is a bioactive phenol presents mainly in Paeonia suffruticosa Andr. (Paeoniaceae), Paeonia lactiflora Pall., and Dioscorea japonica Thunb. (Dioscoreaceae), harboring various pharmacological activities including anti-inflammatory, antioxidant ...
Wen Wang, Wen Wang, Qiaoyun Li, Qiaoyun Li, Zhongqiu Zhao, Zhongqiu Zhao, Yutong Liu, Yi Wang, Hui Xiong, Hui Xiong, Zhinan Mei, Zhinan Mei   +11 more
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Evaluation of paeonol skin-target delivery from its microsponge formulation: in vitro skin permeation and in vivo microdialysis. [PDF]

PLoS ONE, 2013
The aim of the present study was to design a novel topical skin-target drug-delivery system, the paeonol microsponge, and to investigate its drug-release patterns in dosage form, both in vitro and in vivo.
Sha-Sha Li, Guo-Feng Li, Li Liu, Xiao Jiang, Bin Zhang, Zhi-Gang Liu, Xue-Ling Li, Li-Dong Weng, Ting Zuo, Qiang Liu   +9 more
doaj   +1 more source

Anti-tumor effects of paeonol in melanoma by up-regulating miR-143 and suppressing its target WNT5B

STEMedicine, 2023
Previous studies have shown the potent anti-tumor effect of paeonol, a natural compound extracted from traditional Chinese herb medicine. However, the therapeutic effect and underlying mechanisms of paeonol in melanoma are largely unknown.
Meishan Piao, Guangdong Feng
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Paeonol inhibits the progression of intracerebral haemorrhage by mediating the HOTAIR/UPF1/ACSL4 axis

ASN Neuro, 2021
Intracerebral haemorrhage (ICH) is a devastating subtype of stroke with high morbidity and mortality. It has been reported that paeonol (PAN) inhibits the progression of ICH. However, the mechanism by which paeonol mediates the progression of ICH remains
Zheng-Long Jin, Wen-Ying Gao, Shao-Jun Liao, Tao Yu, Qing Shi, Shang-Zhen Yu, Ye-Feng Cai   +6 more
doaj   +1 more source

Paeonol Attenuates Hepatic Ischemia/Reperfusion Injury by Modulating the Nrf2/HO-1 and TLR4/MYD88/NF-κB Signaling Pathways

Antioxidants, 2022
Hepatic ischemia/reperfusion (HIR) is the most common type of liver injury following several clinical situations. Modulating oxidative stress and inflammation by Nrf2/HO-1 and TLR4/MYD88/NF-κB pathways, respectively, is involved in alleviating HIR injury.
Mohamed A. Morsy, Yasmine F. Ibrahim, Sara Mohamed Naguib Abdel Hafez, Nagwa M. Zenhom, Anroop B. Nair, Katharigatta N. Venugopala, Pottathil Shinu, Seham A. Abdel-Gaber   +7 more
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