Results 81 to 90 of about 34,391 (244)

Artificial Intelligence for Identifying Tumor‐Reactive CD8+ T Cells: Biological Principles, Computational Advances, and Future Directions

Med Research, EarlyView.
This review details a three‐stage paradigm shift for tumor‐reactive CD8+ T‐cell identification: decoding transcriptomic states, deciphering clonal functional efficacy, and molecular‐level therapeutic TCR design. Addressing translational hurdles and generative AI “scientific blind spots”—such as missing catch bonds—we present a visionary roadmap.
Chao Yang, Yingying Sun, Yan Zhang, Yifen Shi, Zhiwen Shi   +4 more
wiley   +1 more source

The number of white blood cells in mice administered with saline, 5-Fu, 5-FA, PAE or 5-FA-PAE (×10⁹/L).

, 2014
Each value represents the mean ± SD (n = 12 ...
Zhirong Zhang (659090), Man Li (81239), Xun Sun (364650), Zhen Liang (659089), Tao Gong (178414)   +4 more
core   +1 more source

Advances in conjugated porous polymers via high internal phase emulsion templating

Polymer International, EarlyView.
This mini‐review highlights the design, synthesis and potential applications of π‐conjugated polyHIPEs, emphasizing their unique hierarchical structure and tunable properties. The work outlines innovative synthetic strategies and explores their promising roles in photocatalysis and environmental remediation, paving the way for future advancements in ...
Julie‐Lisa Malaval, Michel Granier, Philippe Gerbier, Sébastien Richeter, Sébastien Clément   +4 more
wiley   +1 more source

Class-F Power Amplifier with Maximized PAE [PDF]

, 2010
Due to the rapid development of telecommunication devices, operating speeds are getting faster and more power is being consumed by those devices. Therefore, there is a big concern on how to prolong the battery life in order to fit consumers’ needs ...
Tsang, Kai Shing
core   +1 more source

An (αβ)2 Architecture of the Arabidopsis thaliana tRNA Splicing Endonuclease Complex: Structural Modeling and Evolutionary Analyses

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT The tRNA splicing endonuclease (TSEN) removes introns from precursor tRNAs (pre‐tRNAs) in eukaryotes and archaea, but the architecture and subunit organization of plant TSEN remain poorly defined. Here, we integrated in planta bimolecular fluorescence complementation (BiFC) assays with AlphaFold3 (AF3)‐based structural modeling, molecular ...
Mohammad Moniruzzaman, Markus Englert, Kazuhito Akama   +2 more
wiley   +1 more source

Associations between low-moderate prenatal alcohol exposure and brain development in childhood

NeuroImage: Clinical
Background: The effects of low-moderate prenatal alcohol exposure (PAE) on brain development have been infrequently studied. Aim: To compare cortical and white matter structure between children aged 6 to 8 years with low-moderate PAE in trimester 1 only,
Deanne K. Thompson, Claire E. Kelly, Thijs Dhollander, Evelyne Muggli, Stephen Hearps, Sharon Lewis, Thi-Nhu-Ngoc Nguyen, Alicia Spittle, Elizabeth J. Elliott, Anthony Penington, Jane Halliday, Peter J. Anderson   +11 more
doaj   +1 more source

Weibull Variational Autoencoder for Remaining Useful Life Prediction

Quality and Reliability Engineering International, EarlyView.
ABSTRACT Remaining useful life (RUL) prediction is a critical technology for preventing unexpected failures and reducing maintenance costs in modern industrial systems. However, traditional model‐based approaches are limited by the need for explicit mathematical modeling of degradation mechanisms, while data‐driven methods often require large‐scale ...
JunWoo Yu, Yoojin Jang, Kwanghui Shin, Jinsoo Jeong, Yong Soo Kim   +4 more
wiley   +1 more source

A Serum‐Resistant Plasma Membrane Probe for Real‐Time Visualization of Pathogen‐Induced Epithelial Barrier Dysfunction

Small, EarlyView.
PM580 selectively activates at the plasma membrane while remaining minimally responsive to serum albumin, enabling serum‐compatible, surface‐confined imaging for 24 h, unlike conventional probes that rapidly internalize and lose membrane contrast.
Yujeong Choi, Sunhwa Jung, Dong Min Kang, Lizaveta Gotina, Minji Kim, Eunmi Ha, Sungsu Lim, Ae Nim Pae, Jaeson Jang, Evgeni Ponimaskin, Ja‐Hyun Baik, Sun‐Joon Min, Yun Kyung Kim   +12 more
wiley   +1 more source

Sexually dimorphic effects of prenatal alcohol exposure on the murine skeleton

Biology of Sex Differences
Background Prenatal alcohol exposure (PAE) can result in lifelong disabilities known as foetal alcohol spectrum disorder (FASD) and is associated with childhood growth deficiencies and increased bone fracture risk.
Lucie E. Bourne, Soher N. Jayash, Lysanne V. Michels, Mark Hopkinson, Fergus M. Guppy, Claire E. Clarkin, Paul Gard, Nigel Brissett, Katherine A. Staines   +8 more
doaj   +1 more source

Highly Configurable Evolutionary Multi‐Objective Optimisation and Application in UAV Path Planning

CAAI Transactions on Intelligence Technology, EarlyView.
ABSTRACT Multi‐objective optimisation is crucial in engineering and real‐world decision‐making. Although traditional decomposition‐based approaches such as MOEA/D yield reasonable results, they depend heavily on expert knowledge. Existing MetaBBO approaches partially alleviate this reliance, however, they offer limited configurability and lack real ...
Kaixu Chen, Yue‐Jiao Gong, Hongshu Guo, Weijia Cao, Jun Zhang   +4 more
wiley   +1 more source