Results 71 to 80 of about 6,965 (203)
The Impact of Paeoniflorin onα-Synuclein Degradation Pathway [PDF]
Evidence-Based Complementary and Alternative Medicine, 2015 Paeoniflorin (PF) is the major active ingredient in the traditional Chinese medicine Radix. It plays a neuroprotective role by regulating autophagy and the ubiquitin-proteasome degradation pathway. In this study, we found PF significantly reduced cell damage caused by MPP+, returning cells to normal state. Cell viability significantly improved after 24
Cai, Zenglin +5 more
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The Regulatory Effects of Paeoniflorin and Its Derivative Paeoniflorin-6′-O-Benzene Sulfonate CP-25 on Inflammation and Immune Diseases [PDF]
Frontiers in Pharmacology, 2019 The plant extract "total glucosides of peony" (TGP) constitutes a mixture of glycosides that is isolated from the roots of the well-known traditional Chinese herb Paeonia lactiflora Pall. Paeoniflorin (Pae) is the most abundant component and the main biologically active ingredient of TGP.
Jiajie Tu +9 more
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Cancer Management and Research, 2018 Zhaotao Wang,1,* Guoyong Yu,2,* Zhi Liu,3 Jianwei Zhu,4 Chen Chen,1 Ru-en Liu,3 Ruxiang Xu1 1Department of Neurosurgery, Affiliated Bayi Brain Hospital, General Army Hospital, Southern Medical University, Beijing, China; 2Department of Neurosurgery ...
Wang Z +6 more
doaj
Pharmacokinetic study of Paeoniflorin Paeonimetabolin-I and Glycyrrhetic acid in humans after oral administration of Paeony Root, Glycyrrhiza and Shakuyaku-kanzo-to (Shao-Yao-Gan-Cao-Tang) [PDF]
, 2000 The pharmacokinetics of Paeoniflorin (PF) , Paeonimetabolin-I (PM-I) and Glycyrrhetic acid (GA) after oral administration of the decoction of Paeony Root (PR) and Glycyrrhiza (GR) and Shakuyaku-kanzo-to (Shao-Yao-Gan-Cao-Tang ; SK) were studied using ...
Akao Teruaki +6 more
core +1 more source
Analytical Science Advances, Volume 6, Issue 2, December 2025.ABSTRACT This study investigates the chemical components of Youjing Granules (YG) and identifies blood‐absorbed components in rat serum following YG administration via gavage. Chemical components and blood‐absorbed components of YG were analysed and identified using ultra‐high‐performance liquid chromatography coupled with hybrid quadrupole‐orbitrap ...
Mingxin Guo +5 more
wiley +1 more source
Dose-Dependent Pharmacokinetics of Paeoniflorin in Rats.
Drug Metabolism and Pharmacokinetics, 1990 The pharmacokinetics of paeoniflorin (PAE) was examined after an iv dose of 20, 40, or 100mg/kg in rats. The decline of plasma concentration was biexponential after each dose. Dose, however, had a marked effect on the pharmacokinetics, with a greater than proportional increase in AUC at 100mg/ kg, even though the increase was proportional at the dose ...
Shiro ISHIDA +2 more
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Paeoniflorin: a review of its pharmacology, pharmacokinetics and toxicity in diabetes
Frontiers in PharmacologyThe escalating global prevalence of diabetes underscores the urgency of addressing its treatment and associated complications. Paeoniflorin, a monoterpenoid glycoside compound, has garnered substantial attention in recent years owing to its potential ...
Xue Ou +6 more
doaj +1 more source
Chemistry Central Journal, 2017 The interaction of paeoniflorin with human serum albumin (HSA) was investigated using fluorescence, UV–vis absorption, circular dichroism (CD) spectra and molecular docking techniques under simulative physiological conditions.
Liang Xu +6 more
doaj +1 more source
Immunomodulatory Biomaterials for Bone and Soft Tissue Chronic Inflammation Diseases
Small Science, Volume 5, Issue 12, December 2025.This review analyzes immunomodulatory biomaterial strategies for treating chronic inflammatory disorders in bone and soft tissues. It explores emerging mechanisms for resolving inflammation while promoting tissue regeneration, offering insights for developing targeted immunotherapeutic approaches that bridge material science with immunology for ...
Yiming Li +7 more
wiley +1 more source
Photochemical Approaches to Complex Chemotypes: Applications in Natural Product Synthesis. [PDF]
, 2016 The use of photochemical transformations is a powerful strategy that allows for the formation of a high degree of molecular complexity from relatively simple building blocks in a single step. A central feature of all light-promoted transformations is the
Kärkäs, Markus D. +2 more
core +2 more sources