Results 31 to 40 of about 33,910 (244)
Advanced Science, EarlyView.SDF‐1 levels decline significantly with maternal aging. Exogenous supplementation restores meiotic spindle morphology, chromosomal alignment, and mitochondrial function while reducing oxidative stress in aged oocytes. Mechanistically, SDF‐1 enhances autophagic activity to clear accumulated stress granules, thereby rescuing fertilization competence and ...
Rui Long +12 more
wiley +1 more source
Advanced Science, EarlyView.This study systematically assessed the global burden and temporal trends of EOTBL cancer in individuals aged 15–49 years. Smoking, ambient particulate matter pollution, and secondhand smoke remain dominant risk factors. Countries within the same Human Development Index (HDI) category exhibit distinct epidemiological trajectories, underscoring the need ...
Ye Tian +8 more
wiley +1 more source
Annals of Neurology, EarlyView.Repeat expansion disorders frequently involve peripheral neuropathy, yet mechanisms remain unclear. Using a spinocerebellar ataxia type 3 (SCA3) Knock‐In Atxn3Q300/Q6, we identify progressive sensorimotor deficits, peripheral nerve pathology, and dorsal root ganglia RNA splicing dysregulation.
Juan P. Mato +7 more
wiley +1 more source
The Anatomical Record, EarlyView.Abstract The middle Permian represents a critical interval in therapsid evolution, when gorgonopsians emerged as some of the first specialized apex predators within terrestrial ecosystems. Despite their significance, the early diversification of Gorgonopsia in Gondwana remains poorly understood due to scarcity and fragmentary material.
Zanildo Macungo +5 more
wiley +1 more source
COMPUTERIZED TOMOGRAPHIC SCANNING OF BRAIN FOR EVALUATION OF CHILDREN WITH DELAYED MILESTONES
Pakistan Armed Forces Medical Journal, 2011 Objective: To assess the utility of Computerized Tomographic (CT) scanning of brain in the evaluation of children with delayed milestones. Study Design: Cross-sectional retrospective study.
Saleem Raza +2 more
doaj +2 more sources
Frontiers in Bioscience-LandmarkNeurodegenerative disorders (NDs), including dementia, Alzheimer’s disease (AD), and Parkinson’s disease (PD), are age-related diseases closely associated with chronic inflammation, oxidative stress, gene mutations, autoimmune-derived inflammation, and ...
Theodora Adamantidi +2 more
doaj +1 more source
Autism Research, EarlyView.ABSTRACT Antidepressant prescribing and autism diagnoses have increased in recent years. We aimed to describe and compare trends in antidepressant prescribing, indications, doses and durations in autistic and non‐autistic males and females in the United Kingdom (UK) from 1997 to 2023.
Aws Sadik +7 more
wiley +1 more source
Pakistan Armed Forces Medical Journal, 2009 Objective: To describe constitution, capabilities and functioning of Pakistan Hajj Medical Mission (Pak HMM) in comparison with six other medical missions during Hajj-2008. Study Design: A comparative cross-sectional study.
Naeem Raza +3 more
doaj +2 more sources
Frontiers in Bioscience-LandmarkPlatelet aggregation and inflammation play a crucial role in atherothrombosis. Wine contains micro-constituents of proper quality and quantity that exert cardioprotective actions, partly through inhibiting platelet-activating factor (PAF), a potent ...
Maria Choleva +2 more
doaj +1 more source
Navigating adverse immunostimulation: A practical guide for clinical researchers
British Journal of Clinical Pharmacology, EarlyView.Problem Setting As drug development moves towards more complex products, early clinical development programmes are increasingly hampered by unwanted and/or unexpected activation of the immune system (adverse immune stimulation, AIS). Solution At the Centre for Human Drug Research, we have introduced standardized procedures to make AIS manageable, while
Juliette A. van den Noort +3 more
wiley +1 more source