Results 51 to 60 of about 60,638 (288)
Circulation Research, 2010 Rationale: The phospholipid platelet-activating factor (PAF) stimulates all cells of the innate immune system and numerous cardiovascular cells. A single enzyme (plasma PAF acetylhydrolase [PAF-AH] or lipoprotein-associated phospholipase [Lp-PL]A2) in ...
Jinbo Liu +5 more
semanticscholar +1 more source
Navigating adverse immunostimulation: A practical guide for clinical researchers
British Journal of Clinical Pharmacology, EarlyView.Problem Setting As drug development moves towards more complex products, early clinical development programmes are increasingly hampered by unwanted and/or unexpected activation of the immune system (adverse immune stimulation, AIS). Solution At the Centre for Human Drug Research, we have introduced standardized procedures to make AIS manageable, while
Juliette A. van den Noort +3 more
wiley +1 more source
Journal of Lipid Research, 2009 Platelet-activating factor (PAF), a phospholipid autacoid with potent effects throughout the innate immune system, is selectively degraded by two small families of PAF acetylhydrolases (PAF-AHs).
T. McIntyre, S. Prescott, D. Stafforini
semanticscholar +1 more source
Biotechnology and Bioengineering, EarlyView.ABSTRACT Hemopexin (Hpx) is an acute phase plasma protein that is responsible for sequestration and removal of cell‐free heme with very high affinity (Kd < 1 pM). Hpx expression in liver cells is induced following an inflammatory event such as severe hemolysis. Therefore, plasma Hpx has potential clinical relevance due to its' ability to bind free heme,
Shuwei Lu +8 more
wiley +1 more source
Biotechnology and Bioengineering, EarlyView.ABSTRACT Modern biopharmaceutical manufacturing requires purification platforms capable of processing structurally and functionally diverse products while addressing the challenge of removing persistent and high‐risk host cell proteins (HCPs).
Wenning Chu +23 more
wiley +1 more source
The human PAF complex coordinates transcription with events downstream of RNA synthesis.
Genes & Development, 2005 The yeast PAF (yPAF) complex interacts with RNA polymerase II and coordinates the setting of histone marks associated with active transcription. We report the isolation and functional characterization of the human PAF (hPAF) complex.
Bing Zhu +7 more
semanticscholar +1 more source
A Decision‐Making Model for Implementing Green Technology in Sustainable Building Projects
Business Strategy and the Environment, EarlyView.ABSTRACT Green technology (GT) adoption is pivotal for reconciling environmental stewardship with economic viability in the built environment, particularly in resource‐constrained emerging economies. However, empirical evidence on how specific GT drivers actively mitigate adoption barriers remains scarce.
Abdelazim Ibrahim +5 more
wiley +1 more source
Pakistan Armed Forces Medical Journal, 2009 Objective: To describe constitution, capabilities and functioning of Pakistan Hajj Medical Mission (Pak HMM) in comparison with six other medical missions during Hajj-2008. Study Design: A comparative cross-sectional study.
Naeem Raza +3 more
doaj +2 more sources
Journal of Immunology, 1979 Platelet activating factor (PAF) released in vivo into the plasmas of rabbits during development of IgE-induced systemic anaphylactic shock had indistinguishable physicochemical and functional properties when compared with PAF released in vitro from ...
R. Neal Pinckard +2 more
semanticscholar +1 more source
Business Strategy and the Environment, EarlyView.ABSTRACT Organisations play a key role in addressing climate change and biodiversity loss, which are closely connected. Biodiversity footprinting has initially suggested that greenhouse gas (GHG) emissions may contribute to a large proportion of many organisations' biodiversity impacts.
Charlotte Maddinson +4 more
wiley +1 more source