Results 41 to 50 of about 117,142 (268)
Chemotherapeutic agents subvert tumor immunity by generating agonists of platelet-activating factor [PDF]
, 2014 Oxidative stress suppresses host immunity by generating oxidized lipid agonists of the platelet-activating factor receptor (PAF-R). Because many classical chemotherapeutic drugs induce reactive oxygen species (ROS), we investigated whether these drugs ...
Al-Hassani, Mohammed +14 more
core +1 more source
Advanced Science, EarlyView.Phospholipase A2 (PLA2), a dormant enzyme, becomes lethal when activated—collapsing lungs in minutes. Our dual therapy (DOPS + varespladib) boosts survival from 0% to >90% in sepsis/ALI. A breakthrough for acute lung injury treatment. ABSTRACT This study reveals that phospholipase A2 (PLA2), normally stable and nontoxic, can be activated specifically ...
Jianyu Wang +7 more
wiley +1 more source
Advanced Science, EarlyView.This study identifies a FOSL2‐driven positive feedback loop that amplifies FSH/FSHR signaling. During FSH‐dependent follicle maturation, FSH induces Fosl2 expression via the cAMP‐PKA‐CREB cascade. FOSL2 in turn binds the promoters of Fshr and estrogen‐biosynthesis genes to enhance their transcription, thereby increasing Fshr mRNA level and amplifying ...
Hongru Shi +13 more
wiley +1 more source
EFEITOS MEDIADOS POR PLAQUETAS NA METÁSTASE
Hematology, Transfusion and Cell Therapy, 2023 Introdução: Evidências sugerem haver estreita comunicação entre células tumorais e plaquetas na conclusão de várias etapas da cascata metastática. Objetivos: Apresentar os principais mecanismos pelos quais as plaquetas contribuem para a metástase por via
JMD Santos, LS Nunes, PAF Oliveira
doaj +1 more source
Antiferromagnetic 4-d O(4) Model [PDF]
, 1996 We study the phase diagram of the four dimensional O(4) model with first (beta1) and second (beta2) neighbor couplings, specially in the beta2 < 0 region, where we find a line of transitions which seems to be second order.
A. M. Ferrenberg +31 more
core +3 more sources
Advanced Energy Materials, EarlyView.This study reports a packaging strategy for perovskite photovoltaic devices using atomic layer deposition (ALD) of aluminum oxide. Through optimization of deposition temperature and oxidant chemistry, researchers develop a 50 nm barrier layer with superior water vapor (WVTR) and oxygen transmission rates (OTR).
Melissa A. Davis +11 more
wiley +1 more source
Negative Effects of Brand Extension
JISR Management and Social Sciences & Economics, 2010 Academicians in general, and students in particular, have recently started idealizing and romanticizing hypotheses-based empirical studies, so much so, that they incorporate hypotheses in their reports and papers, whether there is any need for them or ...
Tariq Jalees, Nadia Tariq
doaj +1 more source
Reversible cross-tolerance to platelet-activating factor signaling by bacterial toxins
Platelets, 2021 Bacterial toxins signaling through Toll-like receptors (TLRs) are implicated in the pathogenesis of many inflammatory diseases. Among the toxins, lipopolysaccharide (LPS) exerts its action via TLR-4 while lipoteichoic acid (LTA) and bacterial ...
Kandahalli Venkataranganayaka Abhilasha +5 more
doaj +1 more source
The Anatomical Record, EarlyView.Abstract The middle Permian represents a critical interval in therapsid evolution, when gorgonopsians emerged as some of the first specialized apex predators within terrestrial ecosystems. Despite their significance, the early diversification of Gorgonopsia in Gondwana remains poorly understood due to scarcity and fragmentary material.
Zanildo Macungo +5 more
wiley +1 more source
Modulation of inflammatory platelet-activating factor (PAF) receptor by the acyl analogue of PAF
Journal of Lipid Research, 2018 Platelet-activating factor (PAF) is a potent inflammatory mediator that exerts its actions via the single PAF receptor (PAF-R). Cells that biosynthesize alkyl-PAF also make abundant amounts of the less potent PAF analogue acyl-PAF, which competes for PAF-
Vyala Hanumanthareddy Chaithra +11 more
doaj +1 more source