Results 51 to 60 of about 11,309,322 (372)
The anabolic steroid stanozolol is a potent inhibitor of human MutT homolog 1
FEBS Letters, EarlyView.MutT homolog 1 (MTH1) is a member of the NUDIX superfamily of enzymes and is an anticancer drug target. We show that stanozolol (Stz), an anabolic steroid, is an unexpected nanomolar inhibitor of MTH1. The X‐ray crystal structure of the human MTH1–Stz complex reveals a unique binding scaffold that could be utilized for future inhibitor development ...
Emma Scaletti Hutchinson +7 more
wiley +1 more source
An Improved Neural Network Model for the Two-Page Crossing Number Problem
IEEE Transactions on Neural Networks, 2006 The simplest graph drawing method is that of putting the vertices of a graph on a line and drawing the edges as half-circles either above or below the line. Such drawings are called two-page book drawings.
Hongmei He, O. Skora, E. Mkinen
semanticscholar +1 more source
, 2012 Full title: The Silver Canon: A Tale of the Western Plains. Published by Sampson, Low, London. Page number(s) as given: not included in pagination.
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FEBS Letters, EarlyView.Tuberculosis remains a global health challenge and new therapeutic targets are required. Here, we characterized SseA, a sulfurtransferase from Mycobacterium tuberculosis involved in macrophage infection, and its interaction with the newly identified protein SufEMtb that activates SseA enzymatic activity.
Giulia Di Napoli +10 more
wiley +1 more source
Frontiers in NutritionBackgroundSince wheat varieties and breeding lines developed by plant breeders in the western Himalayan region (Kashmir) have received limited attention with respect to their physical and protein quality characterization, the focus of the study is to ...
Taha Mukhtar +8 more
doaj +1 more source
, 2012 Full title: From Pole to Pole: A Tale of the Sea. Published by Hodder and Stoughton, London. Page number(s) as given: not included in pagination.
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Aβ42 promotes the aggregation of α‐synuclein splice isoforms via heterogeneous nucleation
FEBS Letters, EarlyView.The aggregation of amyloid‐β (Aβ) and α‐synuclein (αSyn) is associated with Alzheimer's and Parkinson's diseases. This study reveals that Aβ aggregates serve as potent nucleation sites for the aggregation of αSyn and its splice isoforms, shedding light on the intricate interplay between these two pathogenic proteins.
Alexander Röntgen +2 more
wiley +1 more source
Halaman Depan Jurnal Sisfokom (Sistem Informasi dan Komputer) Vol. 8 No. 1 2019
Jurnal Sisfokom, 2019 This article contains front-matter of Sisfokom, Volume 8 Number 1 March 2019, which includes a cover page, title page, editorial team, and table of contents.
Editor in Chief Sisfokom
doaj +1 more source
, 2012 With original illustrations by Chas. J. de Lacy. Published by Frederick Warne, London. Page number(s) as given: not included in pagination.
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FEBS Letters, EarlyView.This work presents the characterization of MvoDUF2193, a Methanococcus voltae (Mvo) protein from the domain of unknown function (DUF) 2193 family. We demonstrate that MvoDUF2193 binds a single [4Fe–4S] cluster per subunit and that cluster occupancy regulates the transition from an apo tetramer to a [4Fe–4S] monomeric form. This structural transition is
Emily M. Dieter +8 more
wiley +1 more source