Results 11 to 20 of about 166,331,801 (189)
New England Journal of Medicine, 1993 Paget's disease of bone may present with bone pain but is often asymptomatic. Treatment (typically with bisphosphonates) is indicated in patients with pain that is localized to an affected site but not in asymptomatic patients.
Ralston, SH
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Gerontologia Clinica, 2009 Paget's disease of bone is a focal bone disorder that is common among older people of Western European descent. It is an unusual disorder, for although we now have safe and highly effective treatment, there are many aspects of its pathogenesis and natural history that we do not yet understand.
Brya, Matthews, Tim, Cundy
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Protocol for stage 2 of the GaP study (genetic testing acceptability for Paget's disease of bone): A questionnaire study to investigate whether relatives of people with Paget's disease would accept genetic testing and preventive treatment if they were available [PDF]
BMC Health Services Research, 2008 Background Paget's disease of bone (PDB) disrupts normal bone architecture and causes pain, deformity, deafness, osteoarthritis, and fractures. Genetic factors play a role in PDB and genetic tests are now conducted for research purposes.
McCallum Marilyn +12 more
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Determinants of quality of life in Paget's disease of bone
Revista Brasileira de ReumatologiaObjective: To evaluate the parameters associated with quality of life in patients with Paget's disease of bone. Methods: Patients with Paget's disease of bone were evaluated with SF-36 and WHOQOL-bref questionnaires.
Gláucio Ricardo Werner de Castro +10 more
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Journal of Clinical Investigation, 2005 Paget disease of bone (PD) is characterized by excessive bone resorption in focal areas followed by abundant new bone formation, with eventual replacement of the normal bone marrow by vascular and fibrous tissue. The etiology of PD is not well understood, but one PD-linked gene and several other susceptibility loci have been identified, and ...
G David, Roodman, Jolene J, Windle
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DIAGNOSIS AND MANAGEMENT OF PAGET'S DISEASE OF BONE - SERIES OF 8 CASES [PDF]
Acta Ortopédica Brasileira, 2019 Paget's disease of bone is a chronic condition characterized by focal abnormalities of absorption and formation of bone, and it may lead to anatomical deformities, pain, fractures, and malignant transformation.
Felipe Augusto Kazan de Oliveira +5 more
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Best Practice & Research Clinical Endocrinology & Metabolism, 2018 Paget's disease of bone is a focal disorder of bone remodelling that progresses slowly and leads to changes in the shape and size of affected bones and to skeletal, articular and vascular complications. In some parts of the world it is the second most common bone disorder after osteoporosis though in recent years its prevalence and severity appear to ...
Appelman-Dijkstra, N.M. +1 more
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Severe congestive heart failure in elderly patient with Paget’s disease
Geriatric Care, 2017 Paget’s disease of bone is characterized by focal areas of increased bone turnover, affecting one or several bones throughout the skeleton. Paget’s disease is often asymptomatic, but can be associated with bone pain and other skeletal and non-skeletal ...
Lorenzo Palleschi, Eleonora Nunziata
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Türk Osteoporoz Dergisi, 2020 Paget’s disease of bone is characterized by a chronic focal bone remodelling disorder, which is usually detected incidentally during routine imagining examinations.
Gonca Sağlam
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Trauma Case Reports, 2021 Introduction: Paget's disease of the bone is a non-malignant skeletal disorder characterized by focal abnormalities in bone remodelling at one or more skeletal sites.
Marjan Raad +4 more
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