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QJM, 1997 SummaryPaget's disease of bone is a relatively common condition in the UK affecting up to 5% of the population over the age of 55 years with particularly high prevalence in the North West of England. The majority of those affected are asymptomatic. Its precise cause remains unknown, and until recently, choice of treatment of this sometimes painful and ...
C G, Ooi, W D, Fraser
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Paget's Disease of the Bone [PDF]
Medical Journal Armed Forces India, 2003 Paget's disease of bone (PDB) is a localised disorder of bone remodelling, characterised by enhanced resorption of bone by giant multinucleated osteoclasis followed by formation of disorganised woven bone by osteoblasts. The resultant bone is expanded, weak and vascular, causing bone pain brittleness and deformity.
K, Narayanan +2 more
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Calcified Tissue International, 1977 Paget’s disease of bone is a focal disorder of unknown etiology characterized initially by excessive resorption and subsequently by excessive formation of bone, culminating in a “mosaic” pattern of lamellar bone associated with extensive local vascularity and increased fibrous tissue in adjacent marrow.
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Best Practice & Research Clinical Endocrinology & Metabolism, 2018 Paget's disease of bone is a focal disorder of bone remodelling that progresses slowly and leads to changes in the shape and size of affected bones and to skeletal, articular and vascular complications. In some parts of the world it is the second most common bone disorder after osteoporosis though in recent years its prevalence and severity appear to ...
Appelman-Dijkstra, N.M. +1 more
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QJM, 2014 Paget's disease is an osteoclastic-mediated disorder of bone that results in abnormal bone resorption associated with inadequate remodeling that leads to mechanically weakened bone. Demonstrating variable geographic prevalence, it is becoming less frequent and age of onset is lengthening in areas of once high prevalence prior to the institution of ...
Gregory, Gruener, Pauline, Camacho
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Gerontologia Clinica, 2009 Sir James Paget described the disease as follows: It begins in middle age or later, is very slow in progress, may continue for many years without influence on the general health, and may give no other trouble than those which are due to the changes of shape, size, and direction of the diseased bones (Paget 1877).
Brya, Matthews, Tim, Cundy
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The Journal of Bone and Joint Surgery. British volume, 1979 This chapter focuses on Paget's disease of bone. The pathological hallmark of the Paget's bone disease is excessive and disorganized activity of bone that involves both matrix and mineral. There is no idea of its cause and little knowledge of its natural history; however, the biochemical changes produced by the overactive bone justify its inclusion as ...
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Trauma Case Reports, 2021 Introduction: Paget's disease of the bone is a non-malignant skeletal disorder characterized by focal abnormalities in bone remodelling at one or more skeletal sites.
Marjan Raad +4 more
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Journal of Orthopaedic Surgery and Research, 2010 Paget's disease of the bone is a common metabolic bone disease in most European countries, Australia, New Zealand, and North America. Conversely, this disease is rare in Scandinavia, Asia, and Africa.
Fukuta Masashi +4 more
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New England Journal of Medicine, 1993 Paget's disease of bone may present with bone pain but is often asymptomatic. Treatment (typically with bisphosphonates) is indicated in patients with pain that is localized to an affected site but not in asymptomatic patients.
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