Results 41 to 50 of about 9,984 (217)
Reumatismo, 2014 Paget’s disease of bone is the most common metabolic bone disease after osteoporosis and affects 2-4% of adults over 55 years of age. Its etiology is only partly understood and includes both genetic and environmental factors.
I. Bertoldi +3 more
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Cells, 2023 Paget’s Disease of Bone (PDB) is a metabolic bone disease that is characterized by dysregulated osteoclast function leading to focal abnormalities of bone remodeling. It can lead to pain, fracture, and bone deformity. G protein-coupled receptor kinase 3 (
Emily M. Rabjohns +15 more
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Paget's Disease of the Bone [PDF]
Medical Journal Armed Forces India, 2003 Paget's disease of bone (PDB) is a localised disorder of bone remodelling, characterised by enhanced resorption of bone by giant multinucleated osteoclasis followed by formation of disorganised woven bone by osteoblasts. The resultant bone is expanded, weak and vascular, causing bone pain brittleness and deformity.
K, Narayanan +2 more
openaire +4 more sources
Cranial Paget’s Disease: A Case Report [PDF]
Türk Nöroloji Dergisi, 2007 Scientific BACKGROUND: Paget’s disease is mostly asymptomatic. Neurological syndromes are uncommon but include headache, dementia, brain stem and cerebellar dysfunction, cranial neuropathies, myelopathy, cauda equina syndrome and radiculopathies.
Fazilet Hız +5 more
doaj
Severe Graves' disease‐associated orbitopathy: A rare case of frontal bone hemangioma
Clinical Case Reports, 2021 Graves' orbitopathy might be severe, requiring treatment with high‐dose glucocorticoids. A lytic bone lesion, malignant lesions, and diseases resulting from bone remodeling processes (eg, Paget's disease) must be excluded by markers and imagery. Outcomes
Ahmad Alamri +5 more
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Characterization of an FTLD-PDB family with the coexistence of SQSTM1 mutation and hexanucleotide (G4C2) repeat expansion in C9orf72 gene [PDF]
, 2016 The C9orf72 expansion is considered a major genetic cause of familial frontotemporal dementia (FTD) in several patients' cohorts. Interestingly, C9orf72 expansion carriers, present also abundant neuronal p62-positive inclusions.
Almeida, MR +8 more
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Osteomalacia in a patient with Paget's bone disease treated with long-term etidronate [PDF]
, 2012 SummaryA 93 year-old woman with Paget\u27s disease of bone had been treated with etidronate without interruption during 20 years. The daily dose was usual (5 mg/kg/day) but this prescription had never been stopped by her physicians.
A. Laffitte +4 more
core +4 more sources
Advanced Science, EarlyView.Schematic model showing the suggested mechanism that ZA induces classical activation of macrophages by impairing mitochondrial biofunction and inhibiting mitochondrial clearance to contribute to the pathological process of BRONJ. RAPA‐loaded nanoparticles ZDPR has shown potential in alleviating BRONJ lesions as well as treating osteoporosis or ...
Hang Zhang +10 more
wiley +1 more source
Romosozumab and Denosumab Combination Therapy After Denosumab in Postmenopausal Osteoporosis
Arthritis &Rheumatology, Accepted Article.Background Transition from long‐term denosumab to PTH‐analogs or romosozumab might expose patients to the risk of the so‐called rebound phenomenon. Adding romosozumab to denosumab might represent an option in patients experiencing a fracture while on denosumab.
Giovanni Adami +10 more
wiley +1 more source
The SQSTM1/p62 UBA domain regulates Ajuba localisation, degradation and NF-κB signalling function
PLoS ONE, 2021 The LIM-domain containing protein Ajuba and the scaffold protein SQSTM1/p62 regulate signalling of NF-κB, a transcription factor involved in osteoclast differentiation and survival.
Melanie A. Sultana +8 more
doaj +2 more sources