Results 41 to 50 of about 11,371 (266)

Microphysiological Systems in Cancer Research: Advancing Immunotherapy through Tumor Microenvironment‐Integrated Organ‐On‐Chip Models

Advanced Therapeutics, EarlyView.
Emerging microphysiological systems reproduce the spatial, biochemical, and cellular complexity of the tumor microenvironment, surpassing 2D cultures and murine models. By integrating patient‐derived tumors, perfusable vasculature, and immune trafficking, these organ‐on‐chip platforms reveal mechanisms of immune evasion, predict therapeutic responses ...
Fabiana Moresi, Francesco Noto, Jyothsna Vasudevan, Xavier Bisteau, Giulia Adriani, Andrea Pavesi   +5 more
wiley   +1 more source

An Uncommon Osseous Frontal Sinus Tumor: Monostotic Paget’s Disease [PDF]

, 2013
Paget's disease of the bone is a disorder characterized by abnormal breakdown and formation of bone tissue. The cause is believed to be either viral or genetic in origin. Most of the time, patients are asymptomatic.
Alfawwaz, Fahad, Kilty, Shaun J., Labajian, Varant, Lai, Chi, Landry, Evie   +4 more
core   +1 more source

Clinical Features, Molecular Biology, and the Metastatic Microenvironment in Lung Cancer Brain Metastases: Implications for Treatment Decisions

Advanced Science, EarlyView.
Brain metastases (BM) from lung cancer are aggressive with poor prognosis. This review covers clinical features, diagnosis, early metastasis, and multi‐omics‐elucidated mechanisms, especially the tumor microenvironment of lung cancer with BM. It also discusses preclinical models, signaling pathways, and emerging therapies.
Yixiang Zhu, Danming He, Zan Hou, Mei Lan, Ye Zhang, Qifeng Wang   +5 more
wiley   +1 more source

Further Evidence That Chondrocalcinosis 1 (CCAL1) is a Confirmed Mendelian Phenotype With a Known Molecular Basis

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Chondrocalcinosis (CCAL), also known as calcium pyrophosphate dihydrate deposition disease (CPPDD), is a frequent multifactorial condition in the elderly, but there are two rare autosomal dominant Mendelian forms, CCAL1 (OMIM %600668) and CCAL2. Only three families with molecularly proven CCAL1 have been reported.
Anna‐Christina Pansa, Mareike Selig, Markus Wingendorf, Matthew A. Brown, Oliver Bartsch   +4 more
wiley   +1 more source

Calcitonin in the treatment of Paget’s disease of bone [PDF]

, 1989
A retrospective survey at the request of Pharmacy & Therapeutics Committee, St. Luke’s Hospital was undertaken to evaluate prescribing habits of calcitonin in Paget’s disease of bone, as well as to assess its effectiveness.peer ...
Mallia, Carmel
core  

Management of post‐implant fibrous dysplasia in the maxilla: A case study

Clinical Advances in Periodontics, EarlyView.
Abstract Background Fibrous dysplasia is generally rare, and even rarer in older adults. Special care is needed when altering the alveolar bone in these cases, especially if an implant is involved. This case study highlights such a scenario. Methods This case study details the experience of a 63‐year‐old African American female who presented with a ...
Yousef Taha Y. Amrou, Anass M. Koleilat, Abdusalam E. Alrmali, Felipe Nor, Hom‐Lay Wang   +4 more
wiley   +1 more source

An incidental finding of the Lincoln sign on FDG PET-CT in a patient with rectosigmoid adenocarcinoma giving rise to the diagnosis of Paget's disease

The Egyptian Journal of Radiology and Nuclear Medicine
Background Paget's disease is a metabolic disorder characterized by disorderly bone remodeling process of excessive osteoclastic and osteoblastic activities leading to a structurally disorganized appearance of the bone.
Muhammad Adib Abdul Onny, Sheila Shazlina Kemis Yahyah, Kavita Arumugam, Nor Salita Ali, Nashrulhaq Tagiling, Norazlina Mat Nawi   +5 more
doaj   +1 more source

Determinants of quality of life in Paget's disease of bone

Revista Brasileira de Reumatologia
Objective: To evaluate the parameters associated with quality of life in patients with Paget's disease of bone. Methods: Patients with Paget's disease of bone were evaluated with SF-36 and WHOQOL-bref questionnaires.
Gláucio Ricardo Werner de Castro, Silvania Ana Fernandes de Castro, Ivanio Alves Pereira, Adriana Fontes Zimmermann, Maria Amazile Toscano, Fabricio Souza Neves, Maria Aparecida Scottini, Juliane Paupitz, Julia Salvan da Rosa, Ziliani Buss, Tânia Silvia Fröde   +10 more
doaj   +1 more source

Protocol for stage 1 of the GaP study (Genetic testing acceptability for Paget's disease of bone): an interview study about genetic testing and preventive treatment: would relatives of people with Paget's disease want testing and treatment if they were available?

BMC Health Services Research, 2006
Background Paget's disease of bone (PDB) is characterised by focal increases in bone turnover, affecting one or more bones throughout the skeleton. This disrupts normal bone architecture and causes pain, deformity, deafness, osteoarthritis, and fractures.
Marteau Theresa M, Entwistle Vikki A, Campbell Marion K, Robertson Clare, Johnston Marie, Langston Anne L, McCallum Marilyn, Ralston Stuart H   +7 more
doaj   +1 more source

Paget's disease (osteitis deformans) [PDF]

, 2009
This issue of eMedRef provides information to clinicians on the pathophysiology, diagnosis, and therapeutics of Paget's ...
Bryce, Brandon
core