Results 61 to 70 of about 2,702,692 (201)

Optineurin Cooperates With NRF2 to Regulate Tooth Root Morphogenesis by Controlling Mitochondrial Dynamics and Apoptosis

Cell Proliferation, EarlyView.
OPTN interacts with NRF2 to facilitate the AKT/DRP1‐mediated regulation of mitochondrial fission in the cytoplasm of SCAPs, promoting tooth root mineralisation. Additionally, OPTN maintains NRF2's nuclear translocation, enhancing the transcriptional regulation of downstream BCL2, ultimately leading to the inhibition apoptosis in SCAPs and regulate ...
Haojie Liu, Xinyu Zhang, Xiao Ge, ChingCho Hsu, Yan Wang, Simai Chen, Xingzhi Yan, Rongyao Xu, Junqing Ma, Shuyu Guo   +9 more
wiley   +1 more source

Measles virus nucleocapsid protein modulates the Signal Regulatory Protein-β1 (SIRPβ1) to enhance osteoclast differentiation in Paget's disease of bone

Bone Reports, 2017
Paget's disease of bone (PDB) is a chronic localized bone disorder in an elderly population. Environmental factors such as paramyxovirus are implicated in PDB and measles virus nucleocapsid protein (MVNP) has been shown to induce pagetic osteoclasts ...
Kumaran Sundaram, Yuvaraj Sambandam, Srinivasan Shanmugarajan, D. Sudhaker Rao, Sakamuri V. Reddy   +4 more
doaj   +1 more source

General analysis of mathematical models for bone remodeling [PDF]

arXiv, 2010
Bone remodeling is regulated by pathways controlling the interplay of osteoblasts and osteoclasts. In this work, we apply the method of generalized modelling to systematically analyse a large class of models of bone remodeling. Our analysis shows that osteoblast precursors can play an important role in the regulation of bone remodeling.
arxiv  

First‐line treatment of osteoporosis with osteoanabolic therapy: a new opportunity

Internal Medicine Journal, EarlyView.
Abstract Osteoporosis is a national health priority, and over six million Australians over the age of 50 years have poor bone health. Fragility fractures due to osteoporosis are associated with an increased morbidity and mortality risk and a high economic cost to the community. It is a chronic condition requiring long‐term management.
Jasna Aleksova, Peter Ebeling
wiley   +1 more source

Paget's disease of bone: An entity still exists in India

Indian Journal of Endocrinology and Metabolism, 2018
Background: Paget's disease of bone (PDB) is uncommonly reported from India. We attempted to study the clinical and imaging features and management of participants who presented with PDB.
Kripa Elizabeth Cherian, Nitin Kapoor, Sahana Shetty, Felix K Jebasingh, Hesarghatta Shyamasunder Asha, Julie Hephzibah, Anne Jennifer Prabhu, Simon Rajaratnam, Nihal Thomas, Thomas Vizhalil Paul   +9 more
doaj   +1 more source

Molecular effect of an OPTN common variant associated to Paget's disease of bone. [PDF]

PLoS ONE, 2018
Paget's disease of bone (PDB) is a chronic bone disorder and although genetic factors appear to play an important role in its pathogenesis, to date PDB causing mutations were identified only in the Sequestosome 1 (SQSTM1) gene at the PDB3 locus.
Iris A L Silva, Natércia Conceição, Édith Gagnon, Jacques P Brown, M Leonor Cancela, Laëtitia Michou   +5 more
doaj   +1 more source

TREATMENT OF PAGET'S DISEASE OF BONE [PDF]

Clinical Endocrinology, 1988
There are two major types of agent available to suppress disease activity: calcitonin, and the bisphosphonates (formerly called diphosphonates). Other agents, including fluoride, mithramycin, actinomycin-D, glucocorticoids, colchicine, glucagon and inosiplex, have also been investigated, but are either ineffective, toxic or ...
D. C. Anderson, J A Cantrill
openaire   +5 more sources

Standard and advanced echocardiographic study of patients with Paget's disease of bone: Evidence of a pagetic heart disease?

Journal of Internal Medicine, EarlyView.
Abstract Background Paget's disease of the bone (PDB) is a metabolic bone disorder involving one or more skeletal sites. Cardiovascular diseases (CVDs) have been described in patients with PDB but have not been systematically analysed. Objectives This study aimed to compare standard and advanced (speckle‐tracking) echocardiographic parameters measured ...
Alfonso Giaquinto, Veronica Abate, Anita Vergatti, Riccardo Muscariello, Adelaide Iervolino, Martina Pucci, Guido Cavati, Filippo Pirrotta, Gianpaolo De Filippo, Roberta Esposito, Lanfranco D'Elia, Daniela Merlotti, Luigi Gennari, Domenico Rendina   +13 more
wiley   +1 more source

Craniodiaphyseal dysplasia, a very rare form of bone dysplasia

Oral and Maxillofacial Surgery Cases, 2020
Introduction: Craniodiaphyseal dysplasia is a very rare autosomal recessive disorder which is typically presented in infancy and characterised by severe form of bone dysplasia, massive bone sclerosis and hyperostosis.
Bayar Ahmed Qasim, Ayad Ahmad Mohammed, Amer A. Balata, Sardar Hassan Arif, Laween Omar Musa   +4 more
doaj  

VCP associated inclusion body myopathy and paget disease of bone knock-in mouse model exhibits tissue pathology typical of human disease. [PDF]

PLoS ONE, 2010
Dominant mutations in the valosin containing protein (VCP) gene cause inclusion body myopathy associated with Paget's disease of bone and frontotemporal dementia (IBMPFD). We have generated a knock-in mouse model with the common R155H mutation.
Mallikarjun Badadani, Angèle Nalbandian, Giles D Watts, Jouni Vesa, Masashi Kitazawa, Hailing Su, Jasmin Tanaja, Eric Dec, Douglas C Wallace, Jogeshwar Mukherjee, Vincent Caiozzo, Matthew Warman, Virginia E Kimonis   +12 more
doaj   +1 more source