GCN2 in proteostasis: structural logic, signalling networks and disease
Threats to protein synthesis activate the kinase GCN2, initiating the integrated stress response (ISR). GCN2 is triggered by stalled ribosomes and uncharged tRNAs, which accumulate when amino acids are scarce. The ISR adjusts cellular physiology by promoting redox balance, protein quality control, and mitochondrial optimisation.
JiaYi Zhu, Stefan J. Marciniak
wiley +1 more source
Machine learning approaches for data-driven hydrocarbon bioaugmentation and phytoremediation: the role of multi-omics insights. [PDF]
Okafor UC +3 more
europepmc +1 more source
A review of skin microbiome and new challenges to cosmetic microbiome‐friendly formulations
Microbiome‐friendly concepts offer new perspectives for a healthy relationship between cosmetic use and the skin microbiome, especially the interaction of non‐biotic cosmetic ingredients with the skin, requiring further studies to clarify the dynamics between the skin microbiome and different classes of cosmetic ingredients.
Yasmin Rosa Santos +3 more
wiley +1 more source
Utilization of Organic Solvents for the Recycling of Waste Wooden Railroad Ties. [PDF]
Nikolić ŽM +6 more
europepmc +1 more source
Impact of Environmental Exposure on Infant Sleep : The Exposome Approach
This review explores how exposure to environmental pollutants during the first 1000 days of life may affect infant sleep. Evidence suggests potential links between chemical exposures and sleep disturbances, underscoring the need for more research on early‐life vulnerability and the impact of pollutants in air, diet, and breast milk.
Zeina Halbouty +6 more
wiley +1 more source
<i>L</i>-region-selective annulative π-extension through dearomative activation of polycyclic aromatic hydrocarbons. [PDF]
Nakata K, Matsuoka W, Ito H, Itami K.
europepmc +1 more source
Characterization of occupational exposure to air pollutants during asphalt milling and paving. [PDF]
Hedmer M +8 more
europepmc +1 more source
ABSTRACT Background Permanent pacemaker (PPM) implantation is recommended in patients with sinus node dysfunction (SND). In patients with coexisting heart failure with preserved ejection fraction (HFpEF), clinicians may be hesitant to treat SND due to concerns about exacerbating heart failure.
Nicole Habel +4 more
wiley +1 more source
Polycyclic aromatic hydrocarbons and polychlorinated biphenyls in tissue of mangrove Rhizophora mangle from the Colombian Caribbean. [PDF]
García-Meléndez L +5 more
europepmc +1 more source

