Results 141 to 150 of about 136,040,587 (306)

PAI-1 deficiency drives pulmonary vascular smooth muscle remodeling and pulmonary hypertension

Pulmonary arterial hypertension (PAH) is a progressive disease characterized by vasoconstriction and remodeling of small pulmonary arteries (PAs). Central to the remodeling process is a switch of pulmonary vascular cells to a proliferative, apoptosis ...
Douglas B Cines (20265111), Geoffrey Newcomb (20265093), Srimathi Bogamuwa (3179145), Mortimer Poncz (1560787), Sergei V Zaitsev (20265081), Joshua P McGuckin (20265084), Dmitry Goncharov (20265087), Iryna Zhyvylo (20265090), Victoria Stepanova (368577), Derek Lin (12966308), Elena A Goncharova (20265114), Bryce Piper (20265096), Benjamin J Buckley (20254644), Tatiana V Kudryashova (20265078), Michael J Kelso (20254647), Horace M DeLisser (20265108), Leyla Teos (20265102), Andressa Pena (12966314), Marie Ranson (25441), Lifeng Jiang (3283797), Aisha Saiyed (20265099), John R Greenland (20265105), Paul J Wolters (16372914), Laszlo Farkas (91352)   +23 more
core  

PAI-1 Produced Ex Vivo by Human Adipose Tissue Is Relevant to PAI-1 Blood Level

, 1999
—Human adipose tissue has been shown to produce plasminogen activator inhibitor type 1 (PAI-1). However, the importance of adipose tissue in the regulation of the PAI-1 plasma level is not known.
I. Juhan-Vague, P. E. Morange, M. Verdier, G. Magalon, D. Casanova, M. C. Alessi   +5 more
core   +1 more source

The Astragaloside IV Derivative LS-102 Ameliorates Obesity-Related Nephropathy

Drug Design, Development and Therapy, 2022
Ziyu Li,1 Wei Yang,1 Yong Yang,1 Jianbo Wu,2 Pei Luo,3 Yong Liu1,4,5 1Department of Pathology, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, People’s Republic of China; 2Drug Discovery Research Center, Southwest Medical ...
Li Z, Yang W, Yang Y, Wu J, Luo P, Liu Y
doaj  

Flexible wearable electronics for cardiovascular monitoring from surface signals to deep physiological insights

FlexMat, EarlyView.
This review organizes flexible wearable electronics for cardiovascular monitoring into four interconnected information layers: surface electrophysiology, hemodynamic sensing, vascular imaging, and biofluid biomarker analysis. This framework clarifies how electrical rhythm, vascular loading, structural and flow‐related features, and biochemical states ...
Qiao Chen, Hongwen Chen, Yuanyuan Li, Pingan Yang, Rui Li, Zhihao Zhou   +5 more
wiley   +1 more source

Craniofacial Resection for Advanced Cutaneous Squamous Cell Carcinoma: Results From the 2nd International Collaborative Case‐Series

Head &Neck, EarlyView.
ABSTRACT Background Robust outcome data for anterior skull base cutaneous squamous cell carcinoma (cSCC) are limited, particularly as emerging therapies reshape management. We evaluated survival and prognostic factors following craniofacial resection. Methods Retrospective multi‐institutional case‐series (1995–2015) of patients who underwent skull base
Michael J. C. Schachtel, Benedict J. Panizza, James J. Bowman, Catherine Barnett, Cristina Valero, Ian Ganly, Snehal G. Patel, Helena Levyn, Dauren Adilbay, Alana Eagan, Marc A. Cohen, Lillian A. Boe, Junting Zheng, Mithat Gonen, Prathamesh Pai, Paolo Castelnuovo, Fang Ju Gao, Cesare Piazza, Piero Nicolai, Luiz P. Kowalski, Ronaldo N. Toledo, Claudio Cernea, Sergio Goncalves, Dan M. Fliss, John R. de Almeida, Ian Witterick, Philippe Herman, Walter Fontanella, Gregorio Sanchez Aniceto, Alvaro Rivero Calle, Sefik Hosal, Serdar Ozer, Subramania Iyer, Richard J. Harvey, C. Rene Leemans, Jan‐Jaap Hendrickx, Marcelo Figari, Luis Boccalatte, Ken Ichi Nibu, Peter Clarke, Catherine Rennie, Yiming Zhu, Rodney J. Schlosser, Fernando L. Dias, Zoukaa Sargi, Shahzada Ahmed, Wojciech Golusinski, Se Heon Kim, Shirley Y. Su, Shaan M. Raza, Franco DeMonte, Ehab Hanna, Jatin P. Shah   +52 more
wiley   +1 more source

Effects of teneligliptin on PDMPs and PAI-1 in patients with diabetes on hemodialysis

, 2016
Yoshinori Okuda,1 Seitaro Omoto,2 Takehito Taniura,3 Akira Shouzu,4 Shosaku Nomura,51Division of Internal Medicine, Meisei Memorial Hospital, 2Division of Internal Medicine, Kohrigaoka Yukeikai Hospital, 3Division of Internal Medicine, Daiwa Hospital ...
Omoto S, Taniura T, Shouzu A, Okuda Y, Nomura S   +4 more
core  

TAFI and PAI-1 levels in human sepsis

, 2006
BACKGROUND: Plasminogen activator inhibitor type-1 (PAI-1) is considered to be the main inhibitor of fibrinolysis in sepsis. However, the contribution of TAFI to the inhibition of fibrinolysis in sepsis is currently unknown. METHODS: TAFI antigen and PAI-
Hack, C Erik, Kohler, Hans Peter, Schroeder, Verena, Zeerleder, Sacha, Wuillemin, Walter A, Zeerleder S, Wuillemin WA, Schröder, Verena, Schroeder V, Hack CE, Kohler, Hans-Peter, Kohler HP   +11 more
core   +1 more source

Inflammatory macrophage-derived plasminogen activator inhibitor-1 exacerbates inflammation through efferocytosis inhibition

Cell Death Discovery
Plasminogen activator inhibitor-1 (PAI-1) is significantly upregulated during inflammatory responses, and elevated PAI-1 levels are associated with poor prognosis in various diseases.
Abd Aziz Ibrahim, Hiromi Miura, Tomoya Terada, Masaki Kawarada, Nobuo Watanabe, Hiroyuki Hosokawa, Masato Ohtsuka, Toshio Miyata, Takashi Yahata   +8 more
doaj   +1 more source

Mental health and healthcare use during COVID‐19 among neurodivergent youth and youth with pre‐existing psychiatric disorders: A systematic review

JCPP Advances, EarlyView.
Abstract Background Neurodivergent youth and youth with pre‐existing psychiatric disorders may have faced additional challenges in navigating the demands and restrictions of the COVID‐19 pandemic. However, less is known about how mental health outcomes and psychiatric healthcare utilization differed across diagnostic groups and other youth‐related ...
Ulyana Sirotina, Bryndis Lara Bjarnadottir, Agnieszka Butwicka, Eivind Ystrom, Jaana Suvisaari, Olli Kiviruusu, Audun Valborgarson, Heiddis Bjork Valdimarsdottir, Helga Ask, Unnur Valdimarsdottir, Thorhildur Halldorsdottir   +10 more
wiley   +1 more source

Nutritional and environmental determinants of maturation and disruption of the early life gut microbiome: A narrative review

Journal of Parenteral and Enteral Nutrition, EarlyView.
Abstract The first 1000 days of life represent a critical window for gut microbiome assembly, with lifelong implications for child growth, immune development, and disease risk. This review synthesizes evidence on maternal, perinatal, and especially nutritional factors that influence early‐life intestinal colonization and highlights the consequences of ...
Carly Burow, Romy Shenderey, Fariha Chowdhury, Nyah Shah, Nikhil Pai   +4 more
wiley   +1 more source