Results 171 to 180 of about 136,040,587 (306)

Bioactive Natural Products in Cardiovascular Disease: Focus on Thrombotic Events

Phytotherapy Research, EarlyView.
An overview of the role of natural products (NP) in cardiovascular disease prevention, highlighting key mechanisms of action: including antiplatelet, antithrombotic, anti‐inflammatory, and antioxidant effects. Additionally, it illustrates the integration of diet–drug interactions, nutritional epigenetics, and the role of artificial intelligence in ...
Maria Nektaria Magkoulia, Despoina Pantazi   +1 more
wiley   +1 more source

Protective Effect of Epigallocatechin‐3‐Gallate Against Fructose‐Induced Metabolic Associated Fatty Liver Disease in Mice by Regulating Ferroptosis and Autophagy via SIRT5

Phytotherapy Research, EarlyView.
ABSTRACT Metabolic dysfunction‐associated fatty liver disease (MAFLD) lacks effective pharmacological therapies and is strongly associated with excessive fructose consumption. Ferroptosis and autophagy dysregulation are increasingly recognized as key drivers of MAFLD progression.
Puyu Zhang, Cuiping Hou, Jiayi Liu, Bosheng Wang, Wenqi Liu, Xin Yang, Yubing Kang, Zequn Liu, Yalin Zhang, Zhuxi Liu, Yuhong Zhao, Lu Zhao   +11 more
wiley   +1 more source

Enhancing severe convection forecasts with microwave radiance assimilation in limited‐area models

Quarterly Journal of the Royal Meteorological Society, EarlyView.
Microwave satellite radiances remain largely underexploited in convection‐permitting limited‐area models. We assess the assimilation of humidity‐sensitive radiances from the MHS instrument in the operational ICON‐2I model, improving the precipitation forecast of a severe convective event over the Marche region, Italy, substantially by correcting ...
Marcello Grenzi, Thomas Gastaldo, Virginia Poli, Chiara Marsigli, Tijana Janjic, Alberto Carrassi   +5 more
wiley   +1 more source

Peptide‐based antibacterial nanoplatforms: Design principles, stimuli‐regulated behaviors, and applications

Responsive Materials, EarlyView.
Peptide‐based antibacterial nanoplatforms, encompassing self‐assembled peptides and peptide‐engineered inorganic, polymeric, and lipid nanocarriers, are systematically reviewed. The article highlights design principles and stimuli‐responsive regulation for improving peptide stability, delivery efficiency, and antibacterial performance.
Peng Tan, Chenlong Zhou, Shuaikang Yang, Zhenduo Chen, Guanghui Zhao, Qi Tang, Haoyu Yan, Feng Li, Xi Ma   +8 more
wiley   +1 more source

SERPINE1 (PAI-1) Regulation in Mechanotransduction-Associated Cellular Senescence. [PDF]

J Cell Biochem
Nisa IC, Chantachotikul P, Takahata K, Ansori ANM, Deguchi S.   +4 more
europepmc   +1 more source

A Comparison of Mobile Laser Scanning Data Acquisition Methods in Closed Forest, Open Woodland and Sub‐Alpine Woodland Ecosystems

Remote Sensing in Ecology and Conservation, EarlyView.
This study demonstrates that the mobile laser scanning (MLS) sampling density required to reliably characterise vegetation structure increases with a site's structural complexity. Applying a five‐level acquisition framework across open woodland, closed forest and sub‐alpine woodland ecosystems, we found that longer scanning paths increased the ...
Johann Tiede, Karin Reinke, Trung H. Nguyen, Simon Jones   +3 more
wiley   +1 more source

Tenecteplase and other TNK formulations lose PAI-1 resistance in their 2-chain form: comparison with alteplase. [PDF]

Blood Adv
Liu Z, Tippett I, McCutcheon F, Keragala CB, McDonald A, Sharma G, Lin L, Xiong Y, Wang Y, Lam T, Cloud GC, Campbell BCV, Parsons MW, Medcalf RL.   +13 more
europepmc   +1 more source

Assessing the Performance of European Union Regions in the “People” and “Prosperity” Pillars of the SDGs

Sustainable Development, EarlyView.
ABSTRACT This paper addresses the gap in subnational assessments of Sustainable Development Goals (SDGs) by benchmarking the performance of European Union NUTS‐2 regions in the People and Prosperity pillars of the 2030 Agenda for Sustainable Development.
Pablo Arocena, Pedro Pascual, Margarita Vega   +2 more
wiley   +1 more source

A structural basis for differential cell signalling by PAI-1 and PAI-2 in breast cancer cells

, 2007
PAI-1 and PAI-2 (plasminogen-activator inibitor types 1 and 2) are inhibitors of cell surface uPA (urokinase plasminogen activator). However, tumour expression of PAI-1 and PAI-2 correlates with poor compared with good patient prognosis in breast cancer ...
Marie Ranson (19586413), Darren Saunders (20117955), Gillian Stillfried (20123934), David Croucher (20119086)   +3 more
core  

Genetic and hemostatic characterization of PAI-1 deficiency and isolated hyperfibrinolysis: data from the RBiN study. [PDF]

Res Pract Thromb Haemost
Haisma B, Nieuwenstein T, Rijpma SR, Simons A, Blijlevens NMA, van Heerde WL, Schols SEM.   +6 more
europepmc   +1 more source