Results 291 to 300 of about 24,664,088 (323)

Апробацiя способу визначення PAI-1

Problems of Environmental Biotechnology, 2021
Запропонований спосiб визначення активностi РАI-1, який дозволяє швидко i з високою точнiстю визначити рiвень цього iнгiбiтора i може бути застосований як iнструмент дiагностування розвитку серцево-судинних захворювань.
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Regulation of cell adhesion by PAI‐1

APMIS, 1999
Type I plasminogen activator inhibitor (PAI‐1) is the primary inhibitor of tissue‐and urokinase‐type plasminogen activators. It circulates in plasma complexed with vitronectin (VN), the primary PAI‐1 binding protein. The somatomedin B (SMB) domain of VN contains both the high affinity PAI‐1 binding site and the specific site for urokinase plasminogen ...
D J, Loskutoff, S A, Curriden, G, Hu, G, Deng   +3 more
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The ‘PAI-1 paradox’ in vascular remodelling

Thrombosis and Haemostasis, 2008
SummaryVascular remodelling isa complex phenomenon associated with restructuring of the vessel wall as a consequence of disruption of vascular homeostasis. Alterations of the vascular wall have been linked to a variety of cardiovascular disorders including atherosclerosis, vascular injury and pulmonary hypertension.
Isabel, Diebold, Damir, Kraicun, Steve, Bonello, Agnes, Görlach   +3 more
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Posttranscriptional regulation of PAI-1 gene expression

Thrombosis and Haemostasis, 2003
SummaryThe plasminogen activator-plasmin cascade is involved in multiple physiological and pathological processes including fibrinolysis, wound healing, fibrosis, angiogenesis, embryo implantation and tumor cell invasion and metastasis. Plasminogen activator-inhibitor type 1 (PAI-1) is the major physiological regulator of plasminogen activation.
Joanne H, Heaton, Wendy M, Dlakic, Thomas D, Gelehrter   +2 more
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Acetylsalicylic acid inhibits platelet PAI-1 antigen release without affecting circulating PAI-1 antigen in plasma

La Ricerca in Clinica e in Laboratorio, 1990
An important plasminogen activator-inhibitor (PAI-1) is present in plasma and concentrated in alpha-granules of platelets. PAI-1 is released during platelet stimulation in vitro. It is presently unknown to what extent the treatment with acetylsalicylic acid (ASA) inhibits platelet PAI-1 release and if release inhibition has an effect on plasma PAI-1 ...
Cogo, A., Ling, E., Sturk, A., ten Cate, J. W., Prandoni, P.   +4 more
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Daytime Fluctuations of Plasminogen Activator Inhibitor 1 (PAI-1) in Populations with High PAI-1 Levels

Thrombosis and Haemostasis, 1992
SummaryThe mechanism underlying diurnal variations in PAI-1 as well as the cellular origin of PAI-1 in subjects with high PAI-1 levels are unknown. We evaluated diurnal changes (8:00 am vs 4:00 pm) in PAI-1 (functional and immunological assays), t-PA Ag and t-PA/PAI-1 complex levels in controls and subjects with high PAI-1 levels.
I, Juhan-Vague, M C, Alessi, D, Raccah, M F, Aillaud, M, Billerey, J, Ansaldi, C, Philip-Joet, P, Vague   +7 more
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Maximal PAI-1 inhibition in vivo requires neutralizing antibodies that recognize and inhibit glycosylated PAI-1

Thrombosis Research, 2012
Plasminogen activator inhibitor-1 (PAI-1) regulates the activity of t-PA and u-PA and is an important inhibitor of the plasminogen activator system. Elevated PAI-1 levels have been implicated in the pathogenesis of several diseases. Prior to the evaluation of PAI-1 inhibitors in humans, there is a strong need to study the effect of PAI-1 inhibition in ...
Britt, Van De Craen, Ilse, Scroyen, Christine, Vranckx, Griet, Compernolle, H Roger, Lijnen, Paul J, Declerck, Ann, Gils   +6 more
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Diurnal Variation in PAI-1 Activity Predominantly Confined to the 4G-allele of the PAI-1 Gene

Thrombosis and Haemostasis, 2002
SummaryWe examined the diurnal pattern in Plasminogen Activator Inhibitor-type 1 (PAI-1) activity and Plasminogen activator (t-PA) in relation to the 4G/5G-polymorphism in the promoter of the PAI-1 gene. The analyses were performed in the Arnhem Elderly Study, a populationbased study of 598 elderly. A single blood sample was drawn and the time of blood
Hoekstra, T., Geleijnse, J.M., Schouten, E.G., Kluft, C.   +3 more
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[Plasminogen activator inhibitor (PAI-1) and diabetes mellitus. I. Regulation of PAI-1 levels].

Vnitrni lekarstvi, 1998
Elevated PAI-1 levels were described in different insulin resistant conditions, incl. diabetes mellitus type II. In its formation probably several stimulating factors participate. Hitherto accomplished studies suggest not only the important effect of insulin acting synergically with very low density.
P, Galajda, L, Sutarík, L, Vladár, J, Stasko, P, Kubisz, M, Mokán   +5 more
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P48. PAI-1

Blood Coagulation & Fibrinolysis, 1996
B. J??rgensen, J. Dalsgaard Nielsen, P. Helligs??, M. Egeblad   +3 more
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