Results 71 to 80 of about 1,718,251 (345)

Smertekartlegging og smertelindring hos pasienter med demens: utfordringer og dilemmaer [PDF]

, 2013
Aim: to explore nurses' experiences with pain assessment and pain relieving in patient with dementia. Background: research shows that patients with dementia are still suffering from unnecessary pain.
Lillekroken, Daniela, Slettebø, Åshild
core   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

Evaluation of Pain in the Pediatric Patient Admitted to Sub-Intensive Care: What Is the Evidence? A Scoping Review

Epidemiologia
Background and Objectives: Inadequate pain treatment in pediatric patients can cause long-term physical and psychological issues. Accurate detection of pain presence and intensity is crucial, especially in Neonatal and Pediatric Sub-Intensive Care Units.
Antonio Bonacaro, Carlotta Granata, Chiara Canini, Lucrezia Anderle, Federica Ambrosi, Maria Chiara Bassi, Giacomo Biasucci, Andrea Contini, Giovanna Artioli, Elisa La Malfa, Massimo Guasconi   +10 more
doaj   +1 more source

Assessment of chronic postsurgical pain after knee replacement : a systematic review [PDF]

, 2013
Objective: Approximately 20% of patients experience chronic pain after total knee replacement (TKR), yet there is no consensus about how best to assess such pain.
Bellamy N, Darzi A, Hewlett SA, Insall JN, National Joint Registry, Schug S   +5 more
core   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Reliability of Three Pain Assessment Tools in Children Requiring Dental Treatment: A Comparative Clinical Study

Journal of Pharmacy and Bioallied Sciences
Background: Accurate pain assessment in pediatric dental patients is crucial for effective pain management and treatment planning. Materials and Methods: A total of 120 children aged 6-12 years, requiring dental treatment, were enrolled in this study ...
Rutika Naik, Singh Anu Arvind, Chhaya B. Patel, Amarnath Biradar, Prasannakumari S. Patil, Manasi Kulkarni, Poonam Joshi   +6 more
doaj   +1 more source

Deep-Learning-Based Models for Pain Recognition: A Systematic Review

Applied Sciences, 2020
Traditional standards employed for pain assessment have many limitations. One such limitation is reliability linked to inter-observer variability. Therefore, there have been many approaches to automate the task of pain recognition.
Rasha M. Al-Eidan, Hend Al-Khalifa, AbdulMalik Al-Salman   +2 more
doaj   +1 more source

The pain experiences of powered wheelchair users [PDF]

, 2011
Copyright © 2012 Informa UK, Ltd. This is the author's accepted manuscript. The final published article is available from the link below.Purpose: To explore the experience of pain and discomfort in users of electric-powered indoor/outdoor wheelchairs ...
Andrew O. Frank, Arthur S, Barnard M, Boninger ML, British Society of Rehabilitation Medicine, Claudius Neophytou, Cooper RA, Department of Health, Frank AO, Frank AO, Health &, Jock MT, Julia L. Frank, Krouskop TA, Lorraine H. De Souza, Ritchie J, Wolf E   +16 more
core   +1 more source

Molecular determinants of signal transduction in tropomyosin receptor kinases

FEBS Open Bio, EarlyView.
Tropomyosin receptor kinases control critical neuronal functions, but how do the same receptors produce diverse cellular responses? This review explores the structural mechanisms behind Trk signaling diversity, focusing on allosteric modulation and ligand bias.
Giray Enkavi
wiley   +1 more source

Dietary nitrate and nitrite protect against doxorubicin‐induced cardiac fibrosis and oxidative protein damage in tumor‐bearing mice

FEBS Open Bio, EarlyView.
Chemotherapies such as doxorubicin can have toxic effects on healthy cardiovascular/heart tissue. Following up on a doxorubicin toxicity study in mice without tumors where nitrate water was cardioprotective (lessened toxicity), this study with tumor‐bearing mice undergoing doxorubicin treatment showed no negative effect of nitrate and nitrite on drug ...
Rama D. Yammani, Xiaofei Chen, Nildris Cruz‐Diaz, Xuewei Zhu, Swati Basu, Daniel B. Kim‐Shapiro, David R. Soto‐Pantoja, Leslie B. Poole   +7 more
wiley   +1 more source