Results 41 to 50 of about 8,115 (216)
Joint Attention, Union with God, and the Dark Night of the Soul [PDF]
, 2013 Eleonore Stump has argued that the fulfilment of union between God and human beings requires a mode of relatedness that can be compared to joint attention, a phenomenon studied in contemporary experimental psychology.
Bungum, Donald
core +1 more source
Congenital Insensitivity to Pain with Anhidrosis (CIPA) Syndrome; A Rare Genetic Disorder Case Story
Case Reports in Clinical Practice, 2022 Congenital insensitivity to pain with anhidrosis (CIPA) is the subtype four of hereditary sensory and autonomic neuropathy (HASN IV), caused by a defect in the NTRK1 gene and presenting early in life.
Zahra Nafei, Marjan Jafari
doaj +1 more source
Novel SCN9A mutations underlying extreme pain phenotypes: unexpected electrophysiological and clinical phenotype correlations. [PDF]
, 2015 The importance of NaV1.7 (encoded by SCN9A) in the regulation of pain sensing is exemplified by the heterogeneity of clinical phenotypes associated with its mutation.
Cox, James J +6 more
core +3 more sources
Ocular manifestations of analgesia syndrom in children
Российский офтальмологический журнал, 2018 Congenital analgesia is characterized by insensitivity to pain. Children with this syndrome feel no physical pain when biting their tongues, lips, cheeks or fingers, which often results in significant bleeding.
L. S. Khamraeva, L. Yu. Bobokha
doaj +1 more source
Loss of Prdm12 during development, but not in mature nociceptors, causes defects in pain sensation
Cell Reports, 2021 Summary: Prdm12 is a key transcription factor in nociceptor neurogenesis. Mutations of Prdm12 cause congenital insensitivity to pain (CIP) from failure of nociceptor development.
Mark A. Landy +4 more
doaj +1 more source
Evaluation of behavior in transgenic mouse models to understand human congenital pain conditions [PDF]
, 2018 BACKGROUND: Containing a brain for signal processing and decision making, and a peripheral component for sensation and response, the nervous system provides higher organisms a powerful method of interacting with their environment.
Bullock, Daniel
core
A Case Report of Congenital Insensitivity to Pain and Anhidrosis (CIPA) [PDF]
, 2012 How to Cite this Article: Karimi M, Fallah R. A Case Report of Congenital Insensitivity to Pain and Anhidrosis (CIPA). Iran J Child Neurol 2012; 6(3): 45-48.
FALLAH, Razieh, KARIMI, Mehran
core +3 more sources
Clinical Genetics, EarlyView.Comprehensive clinical description of 12 subjects with pathogenic PRKAR1B variants, including two heterozygous deletions supporting haploinsufficiency as a possible mechanism of disease, providing valuable insight into the pathophysiology of MASNS and setting a framework upon which to design future mechanistic studies of PKA signaling in brain ...
Sebastian Burkart +17 more
wiley +1 more source
“It’s the end of the world as we know it and we feel fantastic: examining the end of suffering” [PDF]
, 2018 This paper examines the consequences of the transhumanist goal to eliminate the suffering of all sentient beings. While transhumanists identify numerous approaches to this goal, the endgame is genetic modification of humans and natural predators ...
Renstrom, Joelle
core
Children &Society, EarlyView.ABSTRACT According to Article 23 of the United Nations Convention on the Rights of the Child, children with disabilities are entitled to education, including access to high‐quality childcare services. Despite international and national commitments to inclusion, persistent obstacles continue to limit equitable access to childcare services for children ...
François Routhier +23 more
wiley +1 more source