Results 51 to 60 of about 353,220 (297)

A cinesioterapia reduz a dor no membro superior de mulheres submetidas à mastectomia ou quadrantectomia

Revista Dor
JUSTIFICATIVA E OBJETIVOS: A fisioterapia é uma importante ferramenta na reabilitação após a cirurgia para tratamento do câncer de mama. Os objetivos do estudo foram comparar a amplitude de movimento (ADM), a intensidade de dor no membro superior (MS ...
Mariana Tirolli Rett, Paula de Jesus Mesquita, Andreza Rabelo Carvalho Mendonça, Danielly Pereira Moura, Josimari Melo DeSantana   +4 more
doaj   +1 more source

Phase 1, First‐In‐Human, Single‐/Multiple‐Ascending Dose Study of Iluzanebart in Healthy Volunteers

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of iluzanebart, a fully human monoclonal antibody TREM2 (triggering receptor expressed on myeloid cells 2) agonist, after single‐ (SAD) and multiple‐ascending‐dose (MAD) administration.
Andreas Meier, Spyros Papapetropoulos, Andrew Marsh, Kelly Neelon, David Stiles, Ryan O'Mara, Evan A. Thackaberry, Marco Colonna, Raj Rajagovindan   +8 more
wiley   +1 more source

Pain Perception and Migraine

Frontiers in Neurology, 2018
Background: It is well-known that both inter- and intra-individual differences exist in the perception of pain; this is especially true in migraine, an elusive pain disorder of the head. Although electrophysiology and neuroimaging techniques have greatly
Antonio Russo, Antonio Russo, Gianluca Coppola, Francesco Pierelli, Francesco Pierelli, Vincenzo Parisi, Marcello Silvestro, Alessandro Tessitore, Alessandro Tessitore, Gioacchino Tedeschi, Gioacchino Tedeschi, Gioacchino Tedeschi   +11 more
doaj   +1 more source

Universal Proteomic Signature After Exercise‐Induced Muscle Injury in Muscular Dystrophies

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Several neuromuscular disorders (NMDs) are characterized by progressive muscle damage and are marked by the elevation of circulating muscle proteins from activity‐related injury. Despite a diverse array of genetic drivers, many NMDs share similar patterns of exercise intolerance and higher concentrations of muscle injury proteins ...
Mads G. Stemmerik, Benjamin Barthel, Nanna R. Andersen, Sofie V. Skriver, Alan J. Russell, John Vissing   +5 more
wiley   +1 more source

Ação da estimulação elétrica nervosa transcutânea sobre o limiar de dor induzido por pressão

Revista Dor
JUSTIFICATIVA E OBJETIVOS: A estimulação elétrica nervosa transcutânea (TENS) é uma corrente de baixa frequência, utilizada para tratamento de dor, contudo há lacunas com respeito aos parâmetros de uso, bem como do modo de ação.
Aline Patrícia Schulz, Belisa Chang Chao, Franciele Gazola, Gitana Daiala Pereira, Marcos Koiti Nakanishi, Regina Inês Kunz, Talita de Oliveira Canto   +6 more
doaj   +1 more source

Effects of eugenol on pain response to the formalin test and plasma antioxidant activity in high fructose drinking water in male rats

International Journal of Preventive Medicine, 2019
Background: Increased consumption of fructose in recent years has increased the risk of developing metabolic syndrome. In this syndrome, induction of oxidative stress, cellular dysfunction, and decrease of antioxidant capacity can change response to pain.
Omid Ghofran, Tahereh Safari, Mohammad Reza Shahraki   +2 more
doaj   +1 more source

Home‐Based Tele‐tDCS in Amyotrophic Lateral Sclerosis: Feasibility, Safety, and Preliminary Efficacy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease with limited treatment options. Transcranial direct current stimulation (tDCS) shows promise as a neuromodulatory intervention in various neurological disorders, but its application in ALS, particularly in a remote, home‐based format, remains underexplored.
Sangeetha Madhavan, Shravni Deshmukh, Mark Cummings, Aditi Doshi, Kourosh Rezania, Sally Freels, Gina Sawa   +6 more
wiley   +1 more source

Measuring troublesomeness of chronic pain by location [PDF]

BMC Musculoskeletal Disorders, 2006
Abstract Background Current measures of pain assess the relative contribution of pain in different body regions to the overall impact of pain. We developed a series of questions to measure the relative 'troublesomeness' of pain in different body regions (the "troublesomeness grid").
Parsons, S, Carnes, D, Pincus, Tamar, Foster, N, Breen, A, Vogel, S, Underwood, M   +6 more
openaire   +13 more sources

Patients' Global Impression of Change (PGIC) Score Compared to Monthly Migraine Days to Evaluate Treatment Persistence With Anti‐CGRP Monoclonal Antibodies

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT This study assessed whether continued treatment with anti‐CGRP monoclonal antibodies (mAbs) is driven more by reductions in monthly migraine days (MMDs) or patients' global impression of change (PGIC), a patient‐reported outcome. Among 169 patients treated with anti‐CGRP mAbs, 21.3% discontinued due to ineffectiveness. PGIC responders (≥ 5) at
Marina Romozzi, Catello Vollono, Paolo Calabresi, Francesco De Cesaris, Luigi Francesco Iannone   +4 more
wiley   +1 more source

Occurrence, Risk Factors, and Prognosis of Acute Cerebral Microinfarcts in CADASIL

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is the most common monogenic cerebral small vessel disease in adults. This study investigates the occurrence, risk factors, and prognosis of acute cerebral microinfarcts (ACMIs) in patients with CADASIL.
Xuejiao Men, Hui Li, Zhuoxin Guo, Bin Qin, Hengfang Ruan, Ruipeng Cai, Bingjun Zhang, Aimin Wu, Lei Wei, Yongqiang Dai, Haiyan Li, Zhengqi Lu   +11 more
wiley   +1 more source