Results 91 to 100 of about 2,963,635 (350)
Frontiers in Genetics, 2015 CRISPR-Cas systems (clustered regularly interspaced short palindromic repeats/CRISPR-associated proteins) are found in 90% of archaea and about 40% of bacteria. In this original system, CRISPR arrays comprise short, almost unique sequences called spacers
Clément eLier +17 more
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DMSO increases efficiency of genome editing at two non-coding loci. [PDF]
PLoS ONE, 2018 Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/CRISPR-associated protein-9 (Cas9) has become the tool of choice for genome editing.
George Stratigopoulos +4 more
doaj +1 more source
Palindrome complexity bounds for primitive substitution sequences
Discrete Mathematics, 2000 AbstractWe consider one-sided infinite words generated via iteration by primitive substitutions on finite alphabets and provide bounds on the palindrome complexity function as well as uniform bounds on the frequencies of palindromes in such words.
David Damanik +2 more
openaire +2 more sources
Engineering CAR‐T Therapeutics for Enhanced Solid Tumor Targeting
Advanced Materials, EarlyView.CART cell therapy has proven effective for blood cancers but struggles with solid tumors due to diverse antigens and complex environments. Recent efforts focus on improving CAR design and validation platforms. Advances in protein engineering, machine learning, and organoid systems aim to enhance CAR‐T therapy against solid tumors.
Danqing Zhu +4 more
wiley +1 more source
AlleleProfileR: A versatile tool to identify and profile sequence variants in edited genomes.
PLoS ONE, 2019 Gene editing strategies, such as zinc-finger nucleases (ZFNs), transcription activator-like effector nucleases (TALENs), and clustered regularly interspaced short palindromic repeat/Cas9 (CRISPR/Cas9), are revolutionizing biology.
Arne A N Bruyneel +3 more
doaj +1 more source
Palindromic complexity of trees
, 2015 We consider finite trees with edges labeled by letters on a finite alphabet $\varSigma$. Each pair of nodes defines a unique labeled path whose trace is a word of the free monoid $\varSigma^*$.
A Glen +13 more
core +1 more source
Rational Design of Inner Ear Drug Delivery Systems
Advanced Science, EarlyView.Hearing loss is a common disease affecting many people, and inner ear lesions are one of the most important causes. This review focuses on the treatment of inner ear hearing loss by drug delivery systems. It includes the current methods and technologies developed, and it predicts possible directions.
Xiayidan Maimaitikelimu +5 more
wiley +1 more source
Computing maximal palindromes in non-standard matching models [PDF]
arXiv, 2022 Palindromes are popular and important objects in textual data processing, bioinformatics, and combinatorics on words. Let $S = XaY$ be a string where $X$ and $Y$ are of the same length, and $a$ is either a single character or the empty string. Then, there exist two alternative definitions for palindromes: $S$ is said to be a palindrome if $S$ is equal ...
arxiv
Advanced Science, EarlyView.MetaTF is a new computational framework that uses single‐cell RNA sequencing (scRNA‐seq) data to infer transcription factor activity with the aim to help in deciphering cells identity starting from a heterogeneous population, and apply it to characterize mouse hematopoietic stem cells and breast cancer epithelial cells, thus identifying a novel subset ...
Yongfei Hu +15 more
wiley +1 more source
Arabian Journal of Chemistry, 2022 We observed how a change of specific residues in LfcinB dimeric and palindromic sequences caused a notable increase in the cytotoxic activity against CaCo-2 cells while maintaining or even diminishing the level of the cytotoxic effect against normal ...
Andrea Carolina Barragán-Cárdenas +7 more
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