Results 121 to 130 of about 80,570 (319)

The inclusion of sub‐detection limit LA‐ICPMS data, in the analysis of otolith microchemistry, by use of a palindrome sequence analysis (PaSA) [PDF]

, 2007
Ofer Ben-Tzvi, Avigdor Abelson, Steven D. Gaines, Michael Sheehy, Georges Paradis, Moshe Kiflawi   +5 more
openalex   +1 more source

Metagenomic mining reveals novel Cas12 subtypes and their evolutionary diversification

iMetaOmics, EarlyView.
We identified 4112 Cas12 Proteins and 6 new Cas12 subtypes, revealed their significant diversity in N‐terminal regions, repeat sequences, and sequences motifs. We developed an AI‐driven algorithm, Cas12fam, which allows precise annotation of 18 distinct domains in Cas12 proteins.
Meixia Yu, Zilong Zhao, Peiyang Li, Yunpeng Teng, Feng Xu, Zhimeng Li, Zhijia Yang, Hainan Zhao, Huanbin Zhou, Lanqin Xia, Jinsheng Lai, Beibei Xin   +11 more
wiley   +1 more source

Aggregation‐induced emission luminogens in in vitro diagnostics: Advancing biomarker detection in body fluids

Interdisciplinary Medicine, EarlyView.
This review systematically summarizes recent advances in aggregation‐induced emission (AIE) materials for in vitro diagnostics (IVD). It highlights probe design strategies—categorizing them into direct‐responsive, indirect‐responsive, and nano‐immunoprobes—and their applications in detecting a wide range of biomarkers across diverse body fluids ...
Qi Liu, Xirui Chen, Kenian Wang, Yifan Wu, Xiangcai Zou, Ying Li   +5 more
wiley   +1 more source

Structure and function of an AT-rich, interspersed repetitive sequence fromChironomus thummi: solenoidal DNA, 142 bp palindrome-frame and homologies with the sequence for site-specific recombination of bacterial transposons [PDF]

, 1983
Norbert Israelewski
openalex   +1 more source

A clustered regularly interspaced palindromic repeat‐Cas12a‐based assay for rapid dengue virus monitoring in mosquito and clinical samples facilitating global collaborative surveillance and risk assessment to block dengue spreading

Interdisciplinary Medicine, EarlyView.
The RAA‐Cas12a assay outperforms real‐time PCR in sensitivity (92.3%) while matching its specificity (100%) for dengue virus detection in clinical samples. It effectively identifies DENV in mosquitoes, with field data correlating to local outbreaks. This rapid, simple, and precise method serves as an early warning tool for dengue management.
Xiang Guo, Minling Hu, Ying Lu, Xiaohua Liu, Haiyang Chen, Xiaoqing Zhang, Liu Ge, Ziyao Li, Yuji Wang, Qing He, Shu Zeng, Wenwen Ren, Lingzhai Zhao, Zhiqiang Peng, Wushen Chen, Chunmei Wang, Qingming Kong, Shaohong Lu, Fuchun Zhang, Lei Luo, Hua Li, Xiao‐Guang Chen, Xiaohong Zhou   +22 more
wiley   +1 more source

New Technologies Empower Hemophilic Arthropathy Treatment: Focusing on Regenerative Medicine, Molecular Targeting, and Gene Therapy

Medicine Bulletin, EarlyView.
ABSTRACT Hemophilic arthropathy (HA), a major complication of hemophilia, is a chronic osteoarthropathy driven by repeated joint bleeding. Although traditional therapies such as coagulation factor replacement, physical rehabilitation, and surgery can manage symptoms, they cannot fundamentally repair established joint damage or break the pathological ...
Lin Sun, Yingnan Wang, Leyuan Zhao, Liqiang Lu, Fushan Hou, Chuan Yin, Kun Zhang, Yongqiang Hao, Jingke Fu   +8 more
wiley   +1 more source

Synthetic repetitive extragenic palindromic (REP) sequence as an efficient mRNA stabilizer for protein production and metabolic engineering in prokaryotic cells [PDF]

, 2018
Deng Chen, Xueqin Lv, Jianghua Li, Yanfeng Liu, Guocheng Du, Rodrigo Ledesma‐Amaro, Long Liu   +6 more
openalex   +1 more source

CRISPR Enabled Precision Oncology: From Gene Editing to Tumor Microenvironment Remodeling

Med Research, EarlyView.
CRISPR technology has progressed from a prokaryotic immune system to a diverse suite of editing platforms, including Cas nucleases, base and prime editors, and RNA‐targeting enzymes. These advances enable precise genomic and epigenomic interventions, high‐throughput functional screening, and immune engineering.
Kailai Li, Peixin Huang, Yue Qian, Anqi Lin, Jingjun He, Junyi Shen, Li Chen, Kai Miao, Jian Zhang   +8 more
wiley   +1 more source

Unique sequence arrangement of ribosomal genes in the palindromic rDNA molecule of Physarum polycephalum [PDF]

, 1979
Gerald R. Campbell, Virginia C. Littau, Peter W. Melera, Vincent G. Allfrey, Edward M. Johnson   +4 more
openalex   +1 more source

Environmental DNA‐based RPA‐CRISPR/Cas12a assay for on‐site detection of chironomid larvae in aquatic environments

Pest Management Science, EarlyView.
An environmental DNA (eDNA)‐based recombinase polymerase amplification (RPA)‐CRISPR/Cas12a assay enables rapid, specific, and on‐site detection of chironomids, supporting early warning, and ecological monitoring in freshwater environments. Abstract BACKGROUND Freshwater chironomid midges pose a significant threat to drinking water quality and ...
Kyuhyeong Kim, Bhavya Kachiprath, In‐Cheol Yeo, Kyu‐Young Shim, Ihn‐Sil Kwak, Chang‐Bum Jeong   +5 more
wiley   +1 more source