Results 171 to 180 of about 77,661 (325)

Recent advances in isothermal amplification techniques coupled with clustered regularly interspaced short palindromic repeat/Cas systems

Interdisciplinary Medicine, EarlyView.
Abstract Isothermal amplification (IA) techniques have emerged as promising alternatives to polymerase chain reaction (PCR), enabling rapid and efficient nucleic acid amplification at constant temperatures. Meanwhile, clustered regularly interspaced short palindromic repeat (CRISPR)/Cas‐based technology has revolutionized molecular diagnostics by ...
Miao Liu, Yajun Hou, Yuhang Cheng, Ziyun Li, Jiawei Zeng, Li Li, Jinyong Luo, Bo Shen   +7 more
wiley   +1 more source

Repeat expansion by homologous recombination in the mouse germ line at palindromic sequences

, 2001
Zhihong Zhou, Ercan Akgün, Maria Jasin
openalex   +1 more source

HPV Integration: Moving From Carcinogenesis Mechanisms to Clinical Applications

Med Research, EarlyView.
ABSTRACT Human papillomavirus (HPV) is the leading cause of virus‐associated carcinomas, most notably cervical cancer and head and neck cancers. A central mechanism driving HPV‐induced carcinogenesis is the integration of viral DNA into the host genome.
Shaoyang Lai, He Liu, Tian Chu, Canhui Cao   +3 more
wiley   +1 more source

Cloning and Characterization of LUN, a Novel RING Finger Protein That Is Highly Expressed in Lung and Specifically Binds to a Palindromic Sequence

, 2001
Dong Chu, Naoki Kakazu, Manuel J. Gorrín-Rivas, Haiping Lu, Mitsuhiro Kawata, Tatsuo Abe, Kunihiro Ueda, Yoshifumi Adachi   +7 more
openalex   +1 more source

High-throughput application of Palindromic Sequence-Targeted (PST) PCR method for genomic fingerprinting and transposon display

, 2021

openalex   +1 more source

Single and dual RPA‐CRISPR/Cas assays for point‐of‐need detection of Stewart's wilt pathogen (Pantoea stewartii subsp. stewartii) of corn and Maize dwarf mosaic virus

Pest Management Science, Volume 81, Issue 4, Page 1988-1999, April 2025.
Schematic diagram of the single and dual RPA‐CRISPR/Cas12a/13a diagnostic assays for the detection of Pantoea stewartii subsp. stewartii and Maize dwarf mosaic virus. The validated assays provide a useful and sensitive molecular tool for detecting two quarantine pathogens of maize within a minimal resource framework suitable for fast‐tracking the ...
Qian Tian, Hua Zhou, Zhenxing Zhao, Yongjiang Zhang, Wenjun Zhao, Lulu Cai, Tao Guo   +6 more
wiley   +1 more source

Update on Gene Therapy in the Treatment of Hereditary Hearing Loss

Sensory Neuroscience, EarlyView.
Gene therapy is a promising therapeutic approach for genetic disorders, including three major gene therapy strategies: gene replacement, gene suppression, and gene editing. After transmitting genes to the inner ear through appropriate pathways, repair the cochlea in order to achieve the goal of treating hereditary hearing loss.
Weiwei He, Shanying Han, Xinghong Liu, Xiaotong Huang, Wen Yang, Xinghua Tang, Chuan Dong, Jiangang Fan   +7 more
wiley   +1 more source

Survey of clustered regularly interspaced short palindromic repeats and their associated Cas proteins (CRISPR/Cas) systems in multiple sequenced strains of Klebsiella pneumoniae [PDF]

, 2015
Martha Lorena Ostria-Hernández, Carlos Javier Sánchez-Vallejo, J. Antonio Ibarra, Graciela Castro‐Escarpulli   +3 more
openalex   +1 more source

Nature Inspired Delivery Vehicles for CRISPR‐Based Genome Editing

Small, EarlyView.
The review highlights nature‐inspired nanocarriers for CRISPR delivery, emphasizing viral vectors, extracellular vesicles, liposomes, and lipid nanoparticles. It discusses their roles in improving specificity, minimizing immunogenicity, and overcoming barriers in genome editing. Recent advancements, challenges, and therapeutic applications are explored,
Elizabeth Maria Clarissa, Mamata Karmacharya, Hyunmin Choi, Sumit Kumar, Yoon‐Kyoung Cho   +4 more
wiley   +1 more source

Cell Density-Dependent Death Triggered by Viral Palindromic DNA Sequences

, 2023
William P. Robins, Brad Meader, Jonida Toska, John J. Mekalanos   +3 more
openalex   +1 more source