Results 211 to 220 of about 2,912,653 (308)

CRISPR/Cas9‐edited tumor‐associated immune cells in cancer immunotherapy

VIEW, EarlyView.
Abstract Immuno‐oncology represents an emerging field that has significantly transformed tumor therapeutics, with immune cells serving as the cellular foundations of cancer immunotherapy. Due to its high efficiency and sensitivity, CRISPR/Cas9 genome editing is a highly promising technique for precise and rapid gene modification.
Yuhui Ma, Junxin Chen, Yuan Du, Zhihao Cao, Weizhi Ji, Yuyu Niu, Zebin Yang   +6 more
wiley   +1 more source

Med Research: Building Interdisciplinary Bridges and Leading Global Medical Innovation

Med Research, EarlyView.
Quan Cheng, Peng Luo, Xuanlu Shen, Anqi Lin, Zhixiong Liu, Shuofeng Yuan   +5 more
wiley   +1 more source

Cell Density-Dependent Death Triggered by Viral Palindromic DNA Sequences

, 2023
William P. Robins, Brad Meader, Jonida Toska, John J. Mekalanos   +3 more
openalex   +1 more source

Role of mitochondrial complex I genes in host plant expansion of Bactrocera tau (Tephritidae: Diptera) by CRISPR/Cas9 system

Insect Science, EarlyView.
The role of 3 mitochondrial complex I gene in host expansion of Bactrocera tau was verified by CRISPR/Cas9 gene editing system. A stable homogenous strain (Btndufa7‐/‐) of B.tau was established after silencing Ndufa7. The reduced size of larvae and pupae of Ndufa7 knockout strain was first found.Then different levels of fitness and relative expression ...
Wei Shi, Linsheng He, Ruixiang Li, Jun Cao   +3 more
wiley   +1 more source

The transformer gene controls sexual development in Drosophila suzukii

Insect Science, EarlyView.
The transformer gene plays a key role in the genetic pathway for sexual development in Drosophila suzukii Abstract The genetic network of sex determination in the model organism Drosophila melanogaster was investigated in great detail. Such knowledge not only advances our understanding of the evolution and regulation of sexual dimorphism in insects ...
Ying Yan, Jing Zhao, Jonas Schwirz, Cristina Borghesi, Conghui Liu, Bo Liu, Wanqiang Qian, Fanghao Wan, Marc F. Schetelig   +8 more
wiley   +1 more source

Efficient A·T to G·C base conversions in dicots using adenine base editors expressed under the tomato EF1α promoter

, 2023
Plant Biotechnology Journal, Volume 21, Issue 1, Page 5-7, January 2023.
Qingfeng Niu, Siqun Wu, Hongtao Xie, Qi Wu, Ping Liu, Yaping Xu, Zhaobo Lang   +6 more
wiley   +1 more source

RepeatOBserver: Tandem Repeat Visualisation and Putative Centromere Detection

Molecular Ecology Resources, EarlyView.
ABSTRACT Tandem repeats play an important role in centromere structure, subtelomeric regions, DNA methylation, recombination and the regulation of gene activity. Analysis of their distribution in genomes offers a potential means for predicting putative centromere locations, which continues to be a challenge for genome annotation.
Cassandra Elphinstone, Rob Elphinstone, Marco Todesco, Loren H. Rieseberg   +3 more
wiley   +1 more source

Methods for multiancestry genome‐wide association study meta‐analysis

Annals of Human Genetics, EarlyView.
Abstract Genome‐wide association studies (GWAS) have significantly enhanced our understanding of the genetic basis of complex diseases. Despite the technological advancements, gaps in our understanding remain, partly due to small effect sizes and inadequate coverage of genetic variation.
Chuan Fu Yap, Andrew P. Morris
wiley   +1 more source

Innovative all‐in‐one exome sequencing strategy for diagnostic genetic testing in male infertility: Validation and 10‐month experience

Andrology, EarlyView.
Abstract Background Current guidelines indicate that patients with extreme oligozoospermia or azoospermia should be tested for chromosomal imbalances, azoospermia factor (AZF) deletions and/or CFTR variants. For other sperm abnormalities, no genetic diagnostics are recommended.
Manon S. Oud, Nicole de Leeuw, Dominique F. C. M. Smeets, Liliana Ramos, Godfried W. van der Heijden, Raoul G. J. Timmermans, Maartje van de Vorst, Tom Hofste, Marlies J. E. Kempers, Marijn F. Stokman, Kathleen W. M. D'Hauwers, Brigitte H. W. Faas, Dineke Westra   +12 more
wiley   +1 more source

Reproductive sterility in aquaculture: A review of induction methods and an emerging approach with application to Pacific Northwest finfish species

Reviews in Aquaculture, Volume 15, Issue 1, Page 220-241, January 2023., 2023
Abstract Aquaculture is the fastest‐growing food‐production sector and is striving to become a long‐term sustainable approach to meet the rising global demand for seafood. During the expansion and advancement of aquaculture, minimizing ecological impacts should occur concomitantly with maximizing production. Farmed fish, often genetically distinct from
Lan Xu, Mingli Zhao, Jun Hyung Ryu, Edward S. Hayman, William T. Fairgrieve, Yonathan Zohar, J. Adam Luckenbach, Ten‐Tsao Wong   +7 more
wiley   +1 more source