Results 261 to 270 of about 77,661 (325)

Applications of CRISPR-Cas-Based Genome Editing Approaches Against Human Cytomegalovirus Infection. [PDF]

Biomedicines
Zhang A, Zhang I, Liu F.
europepmc   +1 more source

A hypersensitive response‐like lesion‐inducing protein modulates basal immunity against grey leaf spot in maize

Plant Biotechnology Journal, EarlyView.
Tao Zhong, Chenyu Guo, Suining Deng, Mang Zhu, QianQian Zhang, Mingliang Xu   +5 more
wiley   +1 more source

Exploring AAV‐Mediated Gene Therapy for Inner Ear Diseases: from Preclinical Success to Clinical Potential

Advanced Science, Volume 12, Issue 33, September 4, 2025.
Current preclinical studies of AAV‐mediated gene therapy explore different strategies based on the characteristics of inner ear diseases. For genetic hearing loss, approaches include the replacement of a “good gene,” removal of a “bad gene,” or direct correction of mutations through base editing.
Fan Wu, Wuhui He, Yun Xiao, Qiong Wu, Qing Zhang, Tiesong Zhang, Lei Xu, Xinyi Pang   +7 more
wiley   +1 more source

Acquired CRISPR spacers and rhamnose-glucose polysaccharide defects confer resistance to <i>Streptococcus mutans</i> phage ɸAPCM01. [PDF]

Microbiology (Reading)
Wall LA, Wall D.
europepmc   +1 more source

Engineered Cas12j‐8 is a Versatile Platform for Multiplexed Genome Modulation in Mammalian Cells

Advanced Science, Volume 12, Issue 33, September 4, 2025.
Engineered through structure‐guided protein engineering, enCas12j‐8 significantly enhances the editing efficiency of compact Cas12j‐8 while maintaining high specificity. It enables efficient multiplexed genome editing and base editing using a single crRNA array, demonstrating broad applicability and therapeutic potential in genome engineering ...
Ru Meng, Jiayao Li, Wuke Wang, Dong Liang, Zhanwei Li, Cong Mao, Qingyang Li, Yu Zhang, Hao Chen, Jin Tang, Ping Hu, Qi Niu, Xingxu Huang, Bin Shen, Jun Zhang   +14 more
wiley   +1 more source

Microbial diversity and function in the rhizosphere microbiome: Driving forces and monitoring approaches

Agrosystems, Geosciences &Environment, Volume 8, Issue 3, September 2025.
Abstract As an ecological unit, the rhizosphere microbiome preserves an enormous and largely unexplored diversity of microbes that play essential roles in plant health and soil functions. Omics technologies encompassing high‐throughput approaches such as metagenomics, metatranscriptomics, and metaproteomics provide helpful tools to unravel the ...
Chinenyenwa Fortune Chukwuneme, Olubukola Oluranti Babalola   +1 more
wiley   +1 more source

Causal Effects of Inflammatory Cytokines on Bipolar Disorder: A Bidirectional Two‐Sample Mendelian Randomization Study

Brain and Behavior, Volume 15, Issue 9, September 2025.
This study utilized a bidirectional Mendelian randomization approach to delineate the causal relationships between inflammatory cytokines and bipolar disorder. The analysis identified IL‐17, MIP‐1α, and MCP‐3 as being causally linked to an increased risk of bipolar disorder, highlighting their potential roles in the disease etiology and offering ...
Ying Cheng, Meiti Wang, Yu Fang, Jinjie Xu, Jinxin Zheng, Peijun Ju, Jianhua Chen   +6 more
wiley   +1 more source

Comparative analysis of 18 chloroplast genomes reveals genomic diversity and evolutionary dynamics in subtribe Malaxidinae (Orchidaceae). [PDF]

BMC Plant Biol
Li L, Yang W, Liu Q, Jiang X, Wu K, Fang L, Li M, Zeng S, Li S.   +8 more
europepmc   +1 more source

The Mediation of Circulating Inflammatory Proteins in the Causal Pathway From Immune Cells to Delirium

Brain and Behavior, Volume 15, Issue 9, September 2025.
Study design and MR framework. Abstract Objective: Observational research indicates that immune cells, in conjunction with circulating inflammatory proteins, could serve two functions in the development of delirium, despite the fact that the exact mechanisms remain ambiguous.
Tongshuai Liu, Xia Bi, Fuguo Ma, Yanlin Chen   +3 more
wiley   +1 more source